Comparative 3D genome analysis between neural retina and retinal pigment epithelium reveals differential cis-regulatory interactions at retinal disease loci

[Background]: Vision depends on the interplay between photoreceptor cells of the neural retina and the underlying retinal pigment epithelium (RPE). Most genes involved in inherited retinal diseases display specific spatiotemporal expression within these interconnected retinal components through the...

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Detalles Bibliográficos
Autores: D’haene, Eva, López Soriano, Víctor, Martínez-García, Pedro Manuel, Kalayanamontri, Soraya, Dueñas Rey, Alfredo, Sousa Ortega, Ana, Naranjo, Silvia, Sompele, Stijn Van de, Vantomme, Lies, Mahieu, Quinten, Vergult, Sarah, Neto, Ana, Gómez-Skarmeta, José Luis, Martínez-Morales, Juan Ramón, Bauwens, Miriam, Tena, Juan J., Baere, Elfride De
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/367547
Acceso en línea:http://hdl.handle.net/10261/367547
Access Level:acceso abierto
Palabra clave:3D genome structure
Hi-C
HiChIP
UMI-4C
Neural retina
Retinal pigment epithelium (RPE)
Inherited retinal disease (IRD)
ABCA4
Cis-regulatory element (CRE)
Enhancer assay
Descripción
Sumario:[Background]: Vision depends on the interplay between photoreceptor cells of the neural retina and the underlying retinal pigment epithelium (RPE). Most genes involved in inherited retinal diseases display specific spatiotemporal expression within these interconnected retinal components through the local recruitment of cis-regulatory elements (CREs) in 3D nuclear space.

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