Urinary arsenic speciation in children and pregnant women from Spain

Inorganic arsenic (i-As) is a non-threshold human carcinogen that has been associated with several adverse health outcomes. Exposure to i-As is of particular concern among pregnant women, infants and children, as they are specifically vulnerable to the adverse health effects of i-As, and in utero an...

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Autores: Signes-Pastor, Antonio J., Carey, Manus, Vioque, Jesus, Navarrete-Muñoz, Eva-María, Rodríguez Dehli, Cristina, Tardón, Adonina, Begoña Zubero, Miren, Santa Marina, Loreto, Vrijheid, Martine, Casas Sanahuja, Maribel, Llop, Sabrina, González-Palacios, Sandra, Meharg, Andrew A.
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2017
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/69099
Acesso em linha:http://hdl.handle.net/10230/69099
http://dx.doi.org/10.1007/s12403-016-0225-7
Access Level:Acceso aberto
Palavra-chave:Arsenic speciation
Children
Pregnant women
Biomarker
Urinary metabolites
Inorganic arsenic
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spelling Urinary arsenic speciation in children and pregnant women from SpainSignes-Pastor, Antonio J.Carey, ManusVioque, JesusNavarrete-Muñoz, Eva-MaríaRodríguez Dehli, CristinaTardón, AdoninaBegoña Zubero, MirenSanta Marina, LoretoVrijheid, MartineCasas Sanahuja, MaribelLlop, SabrinaGonzález-Palacios, SandraMeharg, Andrew A.Arsenic speciationChildrenPregnant womenBiomarkerUrinary metabolitesInorganic arsenicInorganic arsenic (i-As) is a non-threshold human carcinogen that has been associated with several adverse health outcomes. Exposure to i-As is of particular concern among pregnant women, infants and children, as they are specifically vulnerable to the adverse health effects of i-As, and in utero and early-life exposure, even low to moderate levels of i-As, may have a marked effect throughout the lifespan. Ion chromatography-mass spectrometry detection (IC-ICP-MS) was used to analyse urinary arsenic speciation, as an exposure biomarker, in samples of 4-year-old children with relatively low-level arsenic exposure living in different regions in Spain including Asturias, Gipuzkoa, Sabadell and Valencia. The profile of arsenic metabolites in urine was also determined in samples taken during pregnancy (1st trimester) and in the children from Valencia of 7 years old. The median of the main arsenic species found in the 4-year-old children was 9.71 μg/l (arsenobetaine—AsB), 3.97 μg/l (dimethylarsinic acid—DMA), 0.44 μg/l (monomethylarsonic acid—MMA) and 0.35 μg/l (i-As). Statistically significant differences were found in urinary AsB, MMA and i-As according to the study regions in the 4-year-old, and also in DMA among pregnant women and their children. Spearman’s correlation coefficient among urinary arsenic metabolites was calculated, and, in general, a strong methylation capacity to methylate i-As to MMA was observed.This work was funded by a Marie Curie Intra-European Fellowship within the 7th European Community Framework Programme (RICENIC project—PIEF-GA-2013-622096) and the INMA project (http://www.proyectoinma.org/), which is supported by grants from UE (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1), and from Spain: Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041, FIS-FEDER 03/1615, 04/1509, 04/1112, 04/1436, 04/1931, 04/2018, 05/1079, 05/1052, 06/0867, 06/1213, 07/0314, 08/1151, 09/00090, 09/02311, 09/02647, 11/0178, 11/01007, 11/02591, 11/02038, 13/1944, 13/2032, 13/02187, 13/02429, 14/0891, 14/1687 and Miguel Servet-FEDER CP15/00025), CIBERESP and the Conselleria de Sanitat, Generalitat Valenciana; Generalitat de Catalunya-CIRIT 1999SGR 00241, Fundació La marató de TV3 (090430); Obra Social Cajastur/Fundación Liberbank and UNIVERSIDAD DE OVIEDO; Department of Health of the Basque Government (2005111093, 2009111069 and 2013111089), and the Provincial Government of Gipuzkoa (DFG06/004 and DFG08/001); Convenios anuales con los ayuntamientos de la zona del estudio (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain).Springer202520252017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/69099http://dx.doi.org/10.1007/s12403-016-0225-7reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésExposure and Health . 2017 Jun;9(2):105-11info:eu-repo/grantAgreement/EC/FP7/282957This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/690992026-05-29T05:05:01Z
dc.title.none.fl_str_mv Urinary arsenic speciation in children and pregnant women from Spain
title Urinary arsenic speciation in children and pregnant women from Spain
spellingShingle Urinary arsenic speciation in children and pregnant women from Spain
Signes-Pastor, Antonio J.
Arsenic speciation
Children
Pregnant women
Biomarker
Urinary metabolites
Inorganic arsenic
title_short Urinary arsenic speciation in children and pregnant women from Spain
title_full Urinary arsenic speciation in children and pregnant women from Spain
title_fullStr Urinary arsenic speciation in children and pregnant women from Spain
title_full_unstemmed Urinary arsenic speciation in children and pregnant women from Spain
title_sort Urinary arsenic speciation in children and pregnant women from Spain
dc.creator.none.fl_str_mv Signes-Pastor, Antonio J.
Carey, Manus
Vioque, Jesus
Navarrete-Muñoz, Eva-María
Rodríguez Dehli, Cristina
Tardón, Adonina
Begoña Zubero, Miren
Santa Marina, Loreto
Vrijheid, Martine
Casas Sanahuja, Maribel
Llop, Sabrina
González-Palacios, Sandra
Meharg, Andrew A.
author Signes-Pastor, Antonio J.
author_facet Signes-Pastor, Antonio J.
Carey, Manus
Vioque, Jesus
Navarrete-Muñoz, Eva-María
Rodríguez Dehli, Cristina
Tardón, Adonina
Begoña Zubero, Miren
Santa Marina, Loreto
Vrijheid, Martine
Casas Sanahuja, Maribel
Llop, Sabrina
González-Palacios, Sandra
Meharg, Andrew A.
author_role author
author2 Carey, Manus
Vioque, Jesus
Navarrete-Muñoz, Eva-María
Rodríguez Dehli, Cristina
Tardón, Adonina
Begoña Zubero, Miren
Santa Marina, Loreto
Vrijheid, Martine
Casas Sanahuja, Maribel
Llop, Sabrina
González-Palacios, Sandra
Meharg, Andrew A.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Arsenic speciation
Children
Pregnant women
Biomarker
Urinary metabolites
Inorganic arsenic
topic Arsenic speciation
Children
Pregnant women
Biomarker
Urinary metabolites
Inorganic arsenic
description Inorganic arsenic (i-As) is a non-threshold human carcinogen that has been associated with several adverse health outcomes. Exposure to i-As is of particular concern among pregnant women, infants and children, as they are specifically vulnerable to the adverse health effects of i-As, and in utero and early-life exposure, even low to moderate levels of i-As, may have a marked effect throughout the lifespan. Ion chromatography-mass spectrometry detection (IC-ICP-MS) was used to analyse urinary arsenic speciation, as an exposure biomarker, in samples of 4-year-old children with relatively low-level arsenic exposure living in different regions in Spain including Asturias, Gipuzkoa, Sabadell and Valencia. The profile of arsenic metabolites in urine was also determined in samples taken during pregnancy (1st trimester) and in the children from Valencia of 7 years old. The median of the main arsenic species found in the 4-year-old children was 9.71 μg/l (arsenobetaine—AsB), 3.97 μg/l (dimethylarsinic acid—DMA), 0.44 μg/l (monomethylarsonic acid—MMA) and 0.35 μg/l (i-As). Statistically significant differences were found in urinary AsB, MMA and i-As according to the study regions in the 4-year-old, and also in DMA among pregnant women and their children. Spearman’s correlation coefficient among urinary arsenic metabolites was calculated, and, in general, a strong methylation capacity to methylate i-As to MMA was observed.
publishDate 2017
dc.date.none.fl_str_mv 2017
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/69099
http://dx.doi.org/10.1007/s12403-016-0225-7
url http://hdl.handle.net/10230/69099
http://dx.doi.org/10.1007/s12403-016-0225-7
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Exposure and Health . 2017 Jun;9(2):105-11
info:eu-repo/grantAgreement/EC/FP7/282957
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
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