Immune-inflammatory and hypothalamic-pituitary-adrenal axis biomarkers are altered in patients with non-specific low back pain: A systematic review.

This systematic review aimed to investigate immune-inflammatory and hypothalamic-pituitary-adrenal (HPA) axis biomarkers in individuals with non-specific low back pain (NSLBP) compared to healthy control. The search was performed in five databases until 4 November 2021. Two reviewers independently c...

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Autores: Sanabria Mazo, Juan P., Colomer-Carbonell, Ariadna, Carmona-Cervelló, Meritxell, Feliu-Soler, Albert, Borràs, Xavier, Grasa Martínez, Maria del Mar, Esteve Ràfols, Montserrat, Maes, Michael, Edo, Sílvia, Sanz, Antoni, Luciano, Juan V.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/191683
Acceso en línea:https://hdl.handle.net/2445/191683
Access Level:acceso abierto
Palabra clave:Sistema immunitari
Inflamació
Immunitat cel·lular
Hidrocortisona
Dorsàlgia
Immune system
Inflammation
Cellular immunity
Hydrocortisone
Backache
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spelling Immune-inflammatory and hypothalamic-pituitary-adrenal axis biomarkers are altered in patients with non-specific low back pain: A systematic review.Sanabria Mazo, Juan P.Colomer-Carbonell, AriadnaCarmona-Cervelló, MeritxellFeliu-Soler, AlbertBorràs, XavierGrasa Martínez, Maria del MarEsteve Ràfols, MontserratMaes, MichaelEdo, SílviaSanz, AntoniLuciano, Juan V.Sistema immunitariInflamacióImmunitat cel·lularHidrocortisonaDorsàlgiaImmune systemInflammationCellular immunityHydrocortisoneBackacheThis systematic review aimed to investigate immune-inflammatory and hypothalamic-pituitary-adrenal (HPA) axis biomarkers in individuals with non-specific low back pain (NSLBP) compared to healthy control. The search was performed in five databases until 4 November 2021. Two reviewers independently conducted screenings, data extraction, risk of bias, and methodological quality assessment of 14 unique studies. All studies reported the source of the fluid analyzed: nine studies used serum, two used plasma, one used serum and plasma, and two studies used salivary cortisol. We found preliminary and limited evidence (only one study for each biomarker) of increased levels in growth differentiation factor 15 (GDF-15), interleukin-23 (IL-23), transforming growth factor-beta (TGF-β), and soluble tumor necrosis factor receptor 1 (sTNF-R1) in NSLBP. Inconsistent and limited evidence was identified for interleukin-10 (IL-10). Although C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) levels appear to increase in NSLBP, only one study per each biomarker reported statistically significant differences. Interleukin-1 beta (IL-1β), interleukin-17 (IL-17), interferon gamma (IFN-γ), and high-sensitivity CRP (hsCRP) showed no significant differences. Regarding cortisol, one study showed a significant increase and another a significant decrease. More robust evidence between GDF-15, IL-23, TGF-β, and sTNF-R1 with NSLBP is needed. Moreover, contrary to the findings reported in previous studies, when comparing results exclusively with healthy control, insufficient robust evidence for IL-6, TNF-α, and CRP was found in NSLBP. In addition, cortisol response (HPA-related biomarker) showed a dysregulated functioning in NSLBP, with incongruent evidence regarding its directionality. Therefore, our effort is to find adjusted evidence to conclude which immune-inflammatory and HPA axis biomarkers are altered in NSLBP and how much their levels are affected.Frontiers Media2022202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion14 p.application/pdfhttps://hdl.handle.net/2445/191683Articles publicats en revistes (Bioquímica i Biomedicina Molecular)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3389/fimmu.2022.945513Frontiers in Immunology, 2022, vol. 13, p. 945513https://doi.org/10.3389/fimmu.2022.945513cc-by (c) Sanabria-Mazo, Juan P. et al., 2022http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1916832026-05-29T05:05:01Z
dc.title.none.fl_str_mv Immune-inflammatory and hypothalamic-pituitary-adrenal axis biomarkers are altered in patients with non-specific low back pain: A systematic review.
title Immune-inflammatory and hypothalamic-pituitary-adrenal axis biomarkers are altered in patients with non-specific low back pain: A systematic review.
spellingShingle Immune-inflammatory and hypothalamic-pituitary-adrenal axis biomarkers are altered in patients with non-specific low back pain: A systematic review.
Sanabria Mazo, Juan P.
Sistema immunitari
Inflamació
Immunitat cel·lular
Hidrocortisona
Dorsàlgia
Immune system
Inflammation
Cellular immunity
Hydrocortisone
Backache
title_short Immune-inflammatory and hypothalamic-pituitary-adrenal axis biomarkers are altered in patients with non-specific low back pain: A systematic review.
title_full Immune-inflammatory and hypothalamic-pituitary-adrenal axis biomarkers are altered in patients with non-specific low back pain: A systematic review.
title_fullStr Immune-inflammatory and hypothalamic-pituitary-adrenal axis biomarkers are altered in patients with non-specific low back pain: A systematic review.
title_full_unstemmed Immune-inflammatory and hypothalamic-pituitary-adrenal axis biomarkers are altered in patients with non-specific low back pain: A systematic review.
title_sort Immune-inflammatory and hypothalamic-pituitary-adrenal axis biomarkers are altered in patients with non-specific low back pain: A systematic review.
dc.creator.none.fl_str_mv Sanabria Mazo, Juan P.
Colomer-Carbonell, Ariadna
Carmona-Cervelló, Meritxell
Feliu-Soler, Albert
Borràs, Xavier
Grasa Martínez, Maria del Mar
Esteve Ràfols, Montserrat
Maes, Michael
Edo, Sílvia
Sanz, Antoni
Luciano, Juan V.
author Sanabria Mazo, Juan P.
author_facet Sanabria Mazo, Juan P.
Colomer-Carbonell, Ariadna
Carmona-Cervelló, Meritxell
Feliu-Soler, Albert
Borràs, Xavier
Grasa Martínez, Maria del Mar
Esteve Ràfols, Montserrat
Maes, Michael
Edo, Sílvia
Sanz, Antoni
Luciano, Juan V.
author_role author
author2 Colomer-Carbonell, Ariadna
Carmona-Cervelló, Meritxell
Feliu-Soler, Albert
Borràs, Xavier
Grasa Martínez, Maria del Mar
Esteve Ràfols, Montserrat
Maes, Michael
Edo, Sílvia
Sanz, Antoni
Luciano, Juan V.
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Sistema immunitari
Inflamació
Immunitat cel·lular
Hidrocortisona
Dorsàlgia
Immune system
Inflammation
Cellular immunity
Hydrocortisone
Backache
topic Sistema immunitari
Inflamació
Immunitat cel·lular
Hidrocortisona
Dorsàlgia
Immune system
Inflammation
Cellular immunity
Hydrocortisone
Backache
description This systematic review aimed to investigate immune-inflammatory and hypothalamic-pituitary-adrenal (HPA) axis biomarkers in individuals with non-specific low back pain (NSLBP) compared to healthy control. The search was performed in five databases until 4 November 2021. Two reviewers independently conducted screenings, data extraction, risk of bias, and methodological quality assessment of 14 unique studies. All studies reported the source of the fluid analyzed: nine studies used serum, two used plasma, one used serum and plasma, and two studies used salivary cortisol. We found preliminary and limited evidence (only one study for each biomarker) of increased levels in growth differentiation factor 15 (GDF-15), interleukin-23 (IL-23), transforming growth factor-beta (TGF-β), and soluble tumor necrosis factor receptor 1 (sTNF-R1) in NSLBP. Inconsistent and limited evidence was identified for interleukin-10 (IL-10). Although C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) levels appear to increase in NSLBP, only one study per each biomarker reported statistically significant differences. Interleukin-1 beta (IL-1β), interleukin-17 (IL-17), interferon gamma (IFN-γ), and high-sensitivity CRP (hsCRP) showed no significant differences. Regarding cortisol, one study showed a significant increase and another a significant decrease. More robust evidence between GDF-15, IL-23, TGF-β, and sTNF-R1 with NSLBP is needed. Moreover, contrary to the findings reported in previous studies, when comparing results exclusively with healthy control, insufficient robust evidence for IL-6, TNF-α, and CRP was found in NSLBP. In addition, cortisol response (HPA-related biomarker) showed a dysregulated functioning in NSLBP, with incongruent evidence regarding its directionality. Therefore, our effort is to find adjusted evidence to conclude which immune-inflammatory and HPA axis biomarkers are altered in NSLBP and how much their levels are affected.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/191683
url https://hdl.handle.net/2445/191683
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fimmu.2022.945513
Frontiers in Immunology, 2022, vol. 13, p. 945513
https://doi.org/10.3389/fimmu.2022.945513
dc.rights.none.fl_str_mv cc-by (c) Sanabria-Mazo, Juan P. et al., 2022
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Sanabria-Mazo, Juan P. et al., 2022
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14 p.
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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