Cortical thinning is associated with disease stages and dementia in Parkinson's Disease

Zarei, Mohammad; Ibarretxe Bilbao, Naroa; Compta, Yaroslau; Hough, Morgan; Junqué i Plaja, Carme, 1955-; Bargalló Alabart, Núria; Tolosa, Eduardo; Martí Domènech, Ma. Josep

Cortical thinning is associated with disease stages and dementia in Parkinson's Disease

Objective: To investigate the pattern of cortical thinning in Parkinson's disease (PD) across different disease stages and to elucidate to what extent cortical thinning is related to cognitive impairment. Design: Ninety-six subjects including 39 controls and 57 PD patients participated in this...

Descripción completa

Detalles Bibliográficos
Autores:	Zarei, Mohammad, Ibarretxe Bilbao, Naroa, Compta, Yaroslau, Hough, Morgan, Junqué i Plaja, Carme, 1955-, Bargalló Alabart, Núria, Tolosa, Eduardo, Martí Domènech, Ma. Josep
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2013
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/226499
Acceso en línea:	https://hdl.handle.net/2445/226499
Access Level:	acceso abierto
Palabra clave:	Malaltia de Parkinson Demència Imatges per ressonància magnètica Parkinson's disease Dementia Magnetic resonance imaging

id	ES_0733504f548af90eeab7b271d42e0cbb
oai_identifier_str	oai:recercat.cat:2445/226499
network_acronym_str	ES
network_name_str	España
repository_id_str
spelling	Cortical thinning is associated with disease stages and dementia in Parkinson's DiseaseZarei, MohammadIbarretxe Bilbao, NaroaCompta, YaroslauHough, MorganJunqué i Plaja, Carme, 1955-Bargalló Alabart, NúriaTolosa, EduardoMartí Domènech, Ma. JosepMalaltia de ParkinsonDemènciaImatges per ressonància magnèticaParkinson's diseaseDementiaMagnetic resonance imagingObjective: To investigate the pattern of cortical thinning in Parkinson's disease (PD) across different disease stages and to elucidate to what extent cortical thinning is related to cognitive impairment. Design: Ninety-six subjects including 39 controls and 57 PD patients participated in this study. PD subjects were divided into three groups (early, n=24; moderate, n=18; with dementia, n=15). High field structural brain MRI images were acquired in a 3T scanner and analyses of cortical thickness and surface were carried out. Vertex-wise group comparisons were performed and cortical thickness was correlated with motor and cognitive measures. Results: We found a positive correlation between Mini-Mental State Examination scores and cortical thickness in the anterior temporal, dorsolateral prefrontal, posterior cingulate, temporal fusiform and occipitotemporal cortex. Unified Parkinson's Disease Rating Scale-III (motor subsection) scores showed a robust negative correlation with caudate volumes. We found that disease stage in PD was associated with thinning of the medial frontal (premotor and supplementary motor cortex), posterior cingulate, precuneus, lateral occipital, temporal and dorsolateral prefrontal cortex. Discriminant analysis and a receiver operating characteristics approach showed that mean cortical thickness and hippocampus volume have 80% accuracy in identifying PD patients with dementia. PD stage and PD dementia can be characterised by a specific pattern of cortical thinning. Conclusions: We conclude that measuring cortical thickness can be useful in assessing disease stage and cognitive impairment in patients with PD. In addition, cortical thickness may be useful in identifying dementia in PD.British Medical Journal2026202620132026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion7 p.application/pdfhttps://hdl.handle.net/2445/226499Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1136/jnnp-2012-304126Journal of Neurology Neurosurgery and Psychiatry, 2013, vol. 84, num.8, p. 875-881https://doi.org/10.1136/jnnp-2012-304126cc-by-nc (c) Zarei, Mohammad, et al., 2013https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2264992026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Cortical thinning is associated with disease stages and dementia in Parkinson's Disease
title	Cortical thinning is associated with disease stages and dementia in Parkinson's Disease
spellingShingle	Cortical thinning is associated with disease stages and dementia in Parkinson's Disease Zarei, Mohammad Malaltia de Parkinson Demència Imatges per ressonància magnètica Parkinson's disease Dementia Magnetic resonance imaging
title_short	Cortical thinning is associated with disease stages and dementia in Parkinson's Disease
title_full	Cortical thinning is associated with disease stages and dementia in Parkinson's Disease
title_fullStr	Cortical thinning is associated with disease stages and dementia in Parkinson's Disease
title_full_unstemmed	Cortical thinning is associated with disease stages and dementia in Parkinson's Disease
title_sort	Cortical thinning is associated with disease stages and dementia in Parkinson's Disease
dc.creator.none.fl_str_mv	Zarei, Mohammad Ibarretxe Bilbao, Naroa Compta, Yaroslau Hough, Morgan Junqué i Plaja, Carme, 1955- Bargalló Alabart, Núria Tolosa, Eduardo Martí Domènech, Ma. Josep
author	Zarei, Mohammad
author_facet	Zarei, Mohammad Ibarretxe Bilbao, Naroa Compta, Yaroslau Hough, Morgan Junqué i Plaja, Carme, 1955- Bargalló Alabart, Núria Tolosa, Eduardo Martí Domènech, Ma. Josep
author_role	author
author2	Ibarretxe Bilbao, Naroa Compta, Yaroslau Hough, Morgan Junqué i Plaja, Carme, 1955- Bargalló Alabart, Núria Tolosa, Eduardo Martí Domènech, Ma. Josep
author2_role	author author author author author author author
dc.subject.none.fl_str_mv	Malaltia de Parkinson Demència Imatges per ressonància magnètica Parkinson's disease Dementia Magnetic resonance imaging
topic	Malaltia de Parkinson Demència Imatges per ressonància magnètica Parkinson's disease Dementia Magnetic resonance imaging
description	Objective: To investigate the pattern of cortical thinning in Parkinson's disease (PD) across different disease stages and to elucidate to what extent cortical thinning is related to cognitive impairment. Design: Ninety-six subjects including 39 controls and 57 PD patients participated in this study. PD subjects were divided into three groups (early, n=24; moderate, n=18; with dementia, n=15). High field structural brain MRI images were acquired in a 3T scanner and analyses of cortical thickness and surface were carried out. Vertex-wise group comparisons were performed and cortical thickness was correlated with motor and cognitive measures. Results: We found a positive correlation between Mini-Mental State Examination scores and cortical thickness in the anterior temporal, dorsolateral prefrontal, posterior cingulate, temporal fusiform and occipitotemporal cortex. Unified Parkinson's Disease Rating Scale-III (motor subsection) scores showed a robust negative correlation with caudate volumes. We found that disease stage in PD was associated with thinning of the medial frontal (premotor and supplementary motor cortex), posterior cingulate, precuneus, lateral occipital, temporal and dorsolateral prefrontal cortex. Discriminant analysis and a receiver operating characteristics approach showed that mean cortical thickness and hippocampus volume have 80% accuracy in identifying PD patients with dementia. PD stage and PD dementia can be characterised by a specific pattern of cortical thinning. Conclusions: We conclude that measuring cortical thickness can be useful in assessing disease stage and cognitive impairment in patients with PD. In addition, cortical thickness may be useful in identifying dementia in PD.
publishDate	2013
dc.date.none.fl_str_mv	2013 2026 2026 2026
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/226499
url	https://hdl.handle.net/2445/226499
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.1136/jnnp-2012-304126 Journal of Neurology Neurosurgery and Psychiatry, 2013, vol. 84, num.8, p. 875-881 https://doi.org/10.1136/jnnp-2012-304126
dc.rights.none.fl_str_mv	cc-by-nc (c) Zarei, Mohammad, et al., 2013 https://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc-by-nc (c) Zarei, Mohammad, et al., 2013 https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	7 p. application/pdf
dc.publisher.none.fl_str_mv	British Medical Journal
publisher.none.fl_str_mv	British Medical Journal
dc.source.none.fl_str_mv	Articles publicats en revistes (Medicina) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_	1869402966653403136
score	15.811543

Cortical thinning is associated with disease stages and dementia in Parkinson's Disease

Similares en LA Referencia