Genetic control of wing disc development in Drosophila

In multicellular organisms morphogenesis results from organized cell proliferation and spatial cell differentiation. A genetic approach to development has the two-fold task of explaining how the genetic information is selected and how it expresses itself in developmental operations. The genetic and...

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Detalhes bibliográficos
Autor: García-Bellido, Antonio
Formato: artículo
Estado:Versión publicada
Fecha de publicación:1974
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/47429
Acesso em linha:http://hdl.handle.net/10261/47429
Access Level:acceso abierto
Palavra-chave:Drosophila
Wing
Disc
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spelling Genetic control of wing disc development in DrosophilaGarcía-Bellido, AntonioDrosophilaWingDiscIn multicellular organisms morphogenesis results from organized cell proliferation and spatial cell differentiation. A genetic approach to development has the two-fold task of explaining how the genetic information is selected and how it expresses itself in developmental operations. The genetic and developmental analysis of morphogenetic mutants in Drosophila has thrown some light on both problems. Experiments on genetic mosaics confirm the idea that the genetic information is expressed within the cell itself. The behaviour of those morphogenetic mutants in mosaics suggests the existence of at least two classes of morphogenetic genes. Genes of a first group (cyto-differentiation genes) would include those controlling cell behaviour relevant to morphogenesis and common to most developing systems: mitotic rate, mitotic orientation, cell recognition and cuticular differentiation. Those of a second group (selector genes) seem to control developmental pathways and share several operational characteristics. A functional scheme is advanced showing how selector genes may become activated and control development. We postulate that inductor molecules interfere with the products of activator genes which are selector specific. In this way signals extrinsic to the genome become translated into genetic ones. The activation, or repression, of selector genes occurs once in development and remains clonally irreversible. This, possibly, is the genetic basis of a stable state of determination. However, the products of these activated selector genes are required throughout subsequent development in order to maintain a certain pathway. They may function by activating in turn the corresponding cytodifferentiation genes leading to changes in developmental operations.Peer reviewedElsevierConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201220121974info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/47429reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://www.ncbi.nlm.nih.gov/pubmed/1039909Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/474292026-05-22T06:33:51Z
dc.title.none.fl_str_mv Genetic control of wing disc development in Drosophila
title Genetic control of wing disc development in Drosophila
spellingShingle Genetic control of wing disc development in Drosophila
García-Bellido, Antonio
Drosophila
Wing
Disc
title_short Genetic control of wing disc development in Drosophila
title_full Genetic control of wing disc development in Drosophila
title_fullStr Genetic control of wing disc development in Drosophila
title_full_unstemmed Genetic control of wing disc development in Drosophila
title_sort Genetic control of wing disc development in Drosophila
dc.creator.none.fl_str_mv García-Bellido, Antonio
author García-Bellido, Antonio
author_facet García-Bellido, Antonio
author_role author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Drosophila
Wing
Disc
topic Drosophila
Wing
Disc
description In multicellular organisms morphogenesis results from organized cell proliferation and spatial cell differentiation. A genetic approach to development has the two-fold task of explaining how the genetic information is selected and how it expresses itself in developmental operations. The genetic and developmental analysis of morphogenetic mutants in Drosophila has thrown some light on both problems. Experiments on genetic mosaics confirm the idea that the genetic information is expressed within the cell itself. The behaviour of those morphogenetic mutants in mosaics suggests the existence of at least two classes of morphogenetic genes. Genes of a first group (cyto-differentiation genes) would include those controlling cell behaviour relevant to morphogenesis and common to most developing systems: mitotic rate, mitotic orientation, cell recognition and cuticular differentiation. Those of a second group (selector genes) seem to control developmental pathways and share several operational characteristics. A functional scheme is advanced showing how selector genes may become activated and control development. We postulate that inductor molecules interfere with the products of activator genes which are selector specific. In this way signals extrinsic to the genome become translated into genetic ones. The activation, or repression, of selector genes occurs once in development and remains clonally irreversible. This, possibly, is the genetic basis of a stable state of determination. However, the products of these activated selector genes are required throughout subsequent development in order to maintain a certain pathway. They may function by activating in turn the corresponding cytodifferentiation genes leading to changes in developmental operations.
publishDate 1974
dc.date.none.fl_str_mv 1974
2012
2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/47429
url http://hdl.handle.net/10261/47429
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://www.ncbi.nlm.nih.gov/pubmed/1039909
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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