DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF PHOTO-ACTIVABLE COMPOUNDS AGAINST CANCER STEM CELLS

Azo benzene compounds are widely studied now a days because of their potential light properties. The change of conformation (cis-trans) of these compounds with different wavelengths irradiation opens the possibility of light control over drugs, improving its selectivity over space and time. Therefor...

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Detalles Bibliográficos
Autor: Llamas Rizo, Sandra
Tipo de recurso: otro
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/420857
Acceso en línea:http://hdl.handle.net/10261/420857
Access Level:acceso abierto
Palabra clave:Azobenzene
Cancer stem cells (CSCs)
http://metadata.un.org/sdg/3
http://metadata.un.org/sdg/9
Ensure healthy lives and promote well-being for all at all ages
Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation
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repository_id_str
spelling DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF PHOTO-ACTIVABLE COMPOUNDS AGAINST CANCER STEM CELLSLlamas Rizo, SandraAzobenzeneCancer stem cells (CSCs)http://metadata.un.org/sdg/3http://metadata.un.org/sdg/9Ensure healthy lives and promote well-being for all at all agesBuild resilient infrastructure, promote inclusive and sustainable industrialization and foster innovationAzo benzene compounds are widely studied now a days because of their potential light properties. The change of conformation (cis-trans) of these compounds with different wavelengths irradiation opens the possibility of light control over drugs, improving its selectivity over space and time. Therefore, the possibility of decreasing the side effects of drugs and hence the precise dosing increases the interest of azo benzene compounds on therapeutic applications. Cancer stem cells (CSCs) are known for being responsible of relapse and for its survival over different cancer treatments. It has been observed that CSCs use, among other metabolic routes, autophagy to survive the treatments of cancer eradication. Autophagy is a metabolic pathway by which molecules renew its cellular material, and its inhibition will lead to sever side effects. Photopharmacology, using azo benzene compounds, could be a solution of these side effects, and develop a new cancer treatment with selectivity on tumorous zones with the aim of CSCs eradication by autophagy inhibition. For this purpose, the kinase enzyme ULK1 could be a therapeutic target for its inhibition as it is a protein that regulates the metabolic pathway of autophagy. Docking calculations have been performed to predict and select the photoswitchable molecules with best cis-trans change of activity in the pocket of ULK1 protein. Once the photoswicthable inhibitors were selected, a new synthetic route has been developed for these aminopyrimidine azo benzene compounds, which will be used in the future for further synthesis of similar molecules. A photoswitchable compound has been synthesized and its photochemical properties characterised for further use in biological assays. Photocharacterization has descarted the compound because of its photo chemical properties are not matching the requirements for future biological tests. Another photoswitchable compound has been detected but could not be isolated on the last step of the synthesis, and based on the data recorded of the detection, it seemed to have good photochemical properties for further biological testsPeer reviewedUniversidad de BarcelonaJosa Culleré, LaiaLlebaria, AmadeuVelasco Castrillo, María DoloresConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202620262025info:eu-repo/semantics/otherhttp://purl.org/coar/resource_type/c_46ecinfo:eu-repo/semantics/doctoralThesishttp://hdl.handle.net/10261/420857reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4208572026-05-22T06:33:51Z
dc.title.none.fl_str_mv DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF PHOTO-ACTIVABLE COMPOUNDS AGAINST CANCER STEM CELLS
title DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF PHOTO-ACTIVABLE COMPOUNDS AGAINST CANCER STEM CELLS
spellingShingle DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF PHOTO-ACTIVABLE COMPOUNDS AGAINST CANCER STEM CELLS
Llamas Rizo, Sandra
Azobenzene
Cancer stem cells (CSCs)
http://metadata.un.org/sdg/3
http://metadata.un.org/sdg/9
Ensure healthy lives and promote well-being for all at all ages
Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation
title_short DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF PHOTO-ACTIVABLE COMPOUNDS AGAINST CANCER STEM CELLS
title_full DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF PHOTO-ACTIVABLE COMPOUNDS AGAINST CANCER STEM CELLS
title_fullStr DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF PHOTO-ACTIVABLE COMPOUNDS AGAINST CANCER STEM CELLS
title_full_unstemmed DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF PHOTO-ACTIVABLE COMPOUNDS AGAINST CANCER STEM CELLS
title_sort DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF PHOTO-ACTIVABLE COMPOUNDS AGAINST CANCER STEM CELLS
dc.creator.none.fl_str_mv Llamas Rizo, Sandra
author Llamas Rizo, Sandra
author_facet Llamas Rizo, Sandra
author_role author
dc.contributor.none.fl_str_mv Josa Culleré, Laia
Llebaria, Amadeu
Velasco Castrillo, María Dolores
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Azobenzene
Cancer stem cells (CSCs)
http://metadata.un.org/sdg/3
http://metadata.un.org/sdg/9
Ensure healthy lives and promote well-being for all at all ages
Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation
topic Azobenzene
Cancer stem cells (CSCs)
http://metadata.un.org/sdg/3
http://metadata.un.org/sdg/9
Ensure healthy lives and promote well-being for all at all ages
Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation
description Azo benzene compounds are widely studied now a days because of their potential light properties. The change of conformation (cis-trans) of these compounds with different wavelengths irradiation opens the possibility of light control over drugs, improving its selectivity over space and time. Therefore, the possibility of decreasing the side effects of drugs and hence the precise dosing increases the interest of azo benzene compounds on therapeutic applications. Cancer stem cells (CSCs) are known for being responsible of relapse and for its survival over different cancer treatments. It has been observed that CSCs use, among other metabolic routes, autophagy to survive the treatments of cancer eradication. Autophagy is a metabolic pathway by which molecules renew its cellular material, and its inhibition will lead to sever side effects. Photopharmacology, using azo benzene compounds, could be a solution of these side effects, and develop a new cancer treatment with selectivity on tumorous zones with the aim of CSCs eradication by autophagy inhibition. For this purpose, the kinase enzyme ULK1 could be a therapeutic target for its inhibition as it is a protein that regulates the metabolic pathway of autophagy. Docking calculations have been performed to predict and select the photoswitchable molecules with best cis-trans change of activity in the pocket of ULK1 protein. Once the photoswicthable inhibitors were selected, a new synthetic route has been developed for these aminopyrimidine azo benzene compounds, which will be used in the future for further synthesis of similar molecules. A photoswitchable compound has been synthesized and its photochemical properties characterised for further use in biological assays. Photocharacterization has descarted the compound because of its photo chemical properties are not matching the requirements for future biological tests. Another photoswitchable compound has been detected but could not be isolated on the last step of the synthesis, and based on the data recorded of the detection, it seemed to have good photochemical properties for further biological tests
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/other
http://purl.org/coar/resource_type/c_46ec
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format other
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/420857
url http://hdl.handle.net/10261/420857
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidad de Barcelona
publisher.none.fl_str_mv Universidad de Barcelona
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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