Prognostic value of baseline imaging and clinical features in patients with advanced hepatocellular carcinoma

Aims: To investigate the prognostic value of baseline imaging features for overall survival (OS) and liver decompensation (LD) in patients with hepatocellular carcinoma (HCC). Design: Patients with advanced HCC from the SORAMIC trial were evaluated in this post hoc analysis. Several radiological ima...

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Autores: Öcal, O. (Osman)|||/items/e20f890d-387b-4b27-8cd2-bc265d1c07bb, Ingrisch, M. (Michael)|||/items/b72437c8-ec0b-4910-b7ab-7a88a710229a, Reha-Ümütlü, M. (Muzaffer)|||/items/412d0c0c-2ff3-4c11-bff0-8c81d5c77c75, Peynircioglu, B. (Bora)|||/items/fca68796-d81a-436f-b61d-f6738027cc16, Loewe, C. (Christian)|||/items/164e0698-1ecb-4aa7-a49c-86c53c6b4686, Delden, O.M. (Otto M.) van|||/items/85600314-f061-4c21-8022-54570fcef98b, Vandecaveye, V. (Vincent)|||/items/228974b6-6c34-4de8-8832-52dec9dd333b, Gebauer, B. (Bernhard)|||/items/6cc5be89-3c27-45cd-8e43-cedfe44c9a88, Zech, C.J. (Christoph J.)|||/items/d7e217ff-6d18-4103-a1d1-b11c7f91e05c, Sengel, C. (Christian)|||/items/2a8ebe3b-7e9f-4924-ae83-b565dd6e87a2, Bargellini, I. (Irene)|||/items/2c302084-c5c3-4f12-8876-fc1da43d1c03, Iezzi, R. (Roberto)|||/items/91472f31-aae7-42fe-ac92-c228c63f762d, Benito-Boíllos, A. (Alberto)|||/items/36f5562b-2392-4f6a-a747-a57b8b201069, Pech, M. (Maciej)|||/items/3952e467-7f56-4131-afac-c7864104471f, Malfertheiner, P. (Peter)|||/items/7d7ba999-c5c6-4cf5-9cd3-1dffd4d4d26d, Ricke, J. (Jeans)|||/items/3bfc1d9c-b91e-4e2f-99ca-959622b33e38, Seidensticker, M. (Max)|||/items/5365aab8-55e0-458c-85f0-ff43e3b91270
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/119264
Acceso en línea:https://hdl.handle.net/10171/119264
Access Level:acceso abierto
Palabra clave:Baseline
Overall survival (OS)
Liver decompensation (LD)
Hepatocellular carcinoma (HCC)
Descripción
Sumario:Aims: To investigate the prognostic value of baseline imaging features for overall survival (OS) and liver decompensation (LD) in patients with hepatocellular carcinoma (HCC). Design: Patients with advanced HCC from the SORAMIC trial were evaluated in this post hoc analysis. Several radiological imaging features were collected from baseline computed tomography (CT) and magnetic resonance imaging (MRI) imaging, besides clinical values. The prognostic value of these features for OS and LD (grade 2 bilirubin increase) was quantified with univariate Cox proportional hazard models and multivariate Least Absolute Shrinkage and Selection Operator (LASSO) regression. Results: Three hundred and seventy-six patients were included in this study. The treatment arm was not correlated with OS. LASSO showed satellite lesions, atypical HCC, peritumoral arterial enhancement, larger tumour size, higher albumin-bilirubin (ALBI) score, liver-spleen ratio <1.5, ascites, pleural effusion and higher bilirubin values were predictors of worse OS, and higher relative liver enhancement, smooth margin and capsule were associated with better OS. LASSO analysis for LD showed satellite lesions, peritumoral hypointensity in hepatobiliary phase, high ALBI score, higher bilirubin values and ascites were predictors of LD, while randomisation to sorafenib arm was associated with lower LD. Conclusions: Imaging features showing aggressive tumour biology and poor liver function, in addition to clinical parameters, can serve as imaging biomarkers for OS and LD in patients receiving sorafenib and selective internal radiation therapy for HCC.

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