Distribution of local ancestry and evidence of adaptation in admixed populations

Admixed American populations have different global proportions of European, Sub-Saharan African, and Native-American ancestry. However, individuals who display the same global ancestry could exhibit remarkable differences in the distribution of local ancestry blocks. We studied for the first time th...

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Autores: Secolin, Rodrigo, Mas Sandoval, Àlex, 1989-, Arauna, Lara R, Torres, Fábio R., de Araujo, Tânia K., Santos, Marilza L., Rocha, Cristiane S., Carvalho, Benilton S., Cendes, Fernando, Lopes-Cendes, Iscia, Comas, David, 1969-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/42784
Acceso en línea:http://hdl.handle.net/10230/42784
http://dx.doi.org/10.1038/s41598-019-50362-2
Access Level:acceso abierto
Palabra clave:Evolutionary biology
Genetics
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spelling Distribution of local ancestry and evidence of adaptation in admixed populationsSecolin, RodrigoMas Sandoval, Àlex, 1989-Arauna, Lara RTorres, Fábio R.de Araujo, Tânia K.Santos, Marilza L.Rocha, Cristiane S.Carvalho, Benilton S.Cendes, FernandoLopes-Cendes, IsciaComas, David, 1969-Evolutionary biologyGeneticsAdmixed American populations have different global proportions of European, Sub-Saharan African, and Native-American ancestry. However, individuals who display the same global ancestry could exhibit remarkable differences in the distribution of local ancestry blocks. We studied for the first time the distribution of local ancestry across the genome of 264 Brazilian admixed individuals, ascertained within the scope of the Brazilian Initiative on Precision Medicine. We found a decreased proportion of European ancestry together with an excess of Native-American ancestry on chromosome 8p23.1 and showed that this is due to haplotypes created by chromosomal inversion events. Furthermore, Brazilian non-inverted haplotypes were more similar to Native-American haplotypes than to European haplotypes, in contrast to what was found in other American admixed populations. We also identified signals of recent positive selection on chromosome 8p23.1, and one gene within this locus, PPP1R3B, is related to glycogenesis and has been associated with an increased risk of type 2 diabetes and obesity. These findings point to a selection event after admixture, which is still not entirely understood in recent admixture events.Nature Research201920192019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/42784http://dx.doi.org/10.1038/s41598-019-50362-2reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésScientific Reports. 2019;9(1):13900© The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/427842026-06-12T07:21:37Z
dc.title.none.fl_str_mv Distribution of local ancestry and evidence of adaptation in admixed populations
title Distribution of local ancestry and evidence of adaptation in admixed populations
spellingShingle Distribution of local ancestry and evidence of adaptation in admixed populations
Secolin, Rodrigo
Evolutionary biology
Genetics
title_short Distribution of local ancestry and evidence of adaptation in admixed populations
title_full Distribution of local ancestry and evidence of adaptation in admixed populations
title_fullStr Distribution of local ancestry and evidence of adaptation in admixed populations
title_full_unstemmed Distribution of local ancestry and evidence of adaptation in admixed populations
title_sort Distribution of local ancestry and evidence of adaptation in admixed populations
dc.creator.none.fl_str_mv Secolin, Rodrigo
Mas Sandoval, Àlex, 1989-
Arauna, Lara R
Torres, Fábio R.
de Araujo, Tânia K.
Santos, Marilza L.
Rocha, Cristiane S.
Carvalho, Benilton S.
Cendes, Fernando
Lopes-Cendes, Iscia
Comas, David, 1969-
author Secolin, Rodrigo
author_facet Secolin, Rodrigo
Mas Sandoval, Àlex, 1989-
Arauna, Lara R
Torres, Fábio R.
de Araujo, Tânia K.
Santos, Marilza L.
Rocha, Cristiane S.
Carvalho, Benilton S.
Cendes, Fernando
Lopes-Cendes, Iscia
Comas, David, 1969-
author_role author
author2 Mas Sandoval, Àlex, 1989-
Arauna, Lara R
Torres, Fábio R.
de Araujo, Tânia K.
Santos, Marilza L.
Rocha, Cristiane S.
Carvalho, Benilton S.
Cendes, Fernando
Lopes-Cendes, Iscia
Comas, David, 1969-
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Evolutionary biology
Genetics
topic Evolutionary biology
Genetics
description Admixed American populations have different global proportions of European, Sub-Saharan African, and Native-American ancestry. However, individuals who display the same global ancestry could exhibit remarkable differences in the distribution of local ancestry blocks. We studied for the first time the distribution of local ancestry across the genome of 264 Brazilian admixed individuals, ascertained within the scope of the Brazilian Initiative on Precision Medicine. We found a decreased proportion of European ancestry together with an excess of Native-American ancestry on chromosome 8p23.1 and showed that this is due to haplotypes created by chromosomal inversion events. Furthermore, Brazilian non-inverted haplotypes were more similar to Native-American haplotypes than to European haplotypes, in contrast to what was found in other American admixed populations. We also identified signals of recent positive selection on chromosome 8p23.1, and one gene within this locus, PPP1R3B, is related to glycogenesis and has been associated with an increased risk of type 2 diabetes and obesity. These findings point to a selection event after admixture, which is still not entirely understood in recent admixture events.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/42784
http://dx.doi.org/10.1038/s41598-019-50362-2
url http://hdl.handle.net/10230/42784
http://dx.doi.org/10.1038/s41598-019-50362-2
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Scientific Reports. 2019;9(1):13900
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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