Microfluidic point-of-care blood panel based on a novel technique: Reversible electroosmotic flow
Copyright 2015 AIP Publishing. This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing.
| Autores: | , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2015 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/86065 |
| Acceso en línea: | https://hdl.handle.net/2117/86065 https://dx.doi.org/10.1063/1.4930865 |
| Access Level: | acceso abierto |
| Palabra clave: | Biophysics Blood plasma Microfluidics Electroosmosis Fluidic devices Haemodynamics Microscale flows Plasma channeling Biofísica Plasma sanguini Microfluídica Àrees temàtiques de la UPC::Física |
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Microfluidic point-of-care blood panel based on a novel technique: Reversible electroosmotic flowMohammadi, MahdiMadadi, HojjatCasals Terré, Jasmina|||0000-0002-1368-3950BiophysicsBlood plasmaMicrofluidicsElectroosmosisFluidic devicesHaemodynamicsMicroscale flowsPlasma channelingBiofísicaPlasma sanguiniMicrofluídicaÀrees temàtiques de la UPC::FísicaCopyright 2015 AIP Publishing. This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing.A wide range of diseases and conditions are monitored or diagnosed from blood plasma, but the ability to analyze a whole blood sample with the requirements for a point-of-care device, such as robustness, user-friendliness, and simple handling, remains unmet. Microfluidics technology offers the possibility not only to work fresh thumb-pricked whole blood but also to maximize the amount of the obtained plasma from the initial sample and therefore the possibility to implement multiple tests in a single cartridge. The microfluidic design presented in this paper is a combination of cross-flow filtration with a reversible electroosmotic flow that prevents clogging at the filter entrance and maximizes the amount of separated plasma. The main advantage of this design is its efficiency, since from a small amount of sample (a single droplet 10¿µl) almost 10% of this (approx 1¿µl) is extracted and collected with high purity (more than 99%) in a reasonable time (5–8 min). To validate the quality and quantity of the separated plasma and to show its potential as a clinical tool, the microfluidic chip has been combined with lateral flow immunochromatography technology to perform a qualitative detection of the thyroid-stimulating hormone and a blood panel for measuring cardiac Troponin and Creatine Kinase MB. The results from the microfluidic system are comparable to previous commercial lateral flow assays that required more sample for implementing fewer tests.Peer Reviewed20152015-09-1120162016-04-21journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/86065https://dx.doi.org/10.1063/1.4930865reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/860652026-05-27T15:37:01Z |
| dc.title.none.fl_str_mv |
Microfluidic point-of-care blood panel based on a novel technique: Reversible electroosmotic flow |
| title |
Microfluidic point-of-care blood panel based on a novel technique: Reversible electroosmotic flow |
| spellingShingle |
Microfluidic point-of-care blood panel based on a novel technique: Reversible electroosmotic flow Mohammadi, Mahdi Biophysics Blood plasma Microfluidics Electroosmosis Fluidic devices Haemodynamics Microscale flows Plasma channeling Biofísica Plasma sanguini Microfluídica Àrees temàtiques de la UPC::Física |
| title_short |
Microfluidic point-of-care blood panel based on a novel technique: Reversible electroosmotic flow |
| title_full |
Microfluidic point-of-care blood panel based on a novel technique: Reversible electroosmotic flow |
| title_fullStr |
Microfluidic point-of-care blood panel based on a novel technique: Reversible electroosmotic flow |
| title_full_unstemmed |
Microfluidic point-of-care blood panel based on a novel technique: Reversible electroosmotic flow |
| title_sort |
Microfluidic point-of-care blood panel based on a novel technique: Reversible electroosmotic flow |
| dc.creator.none.fl_str_mv |
Mohammadi, Mahdi Madadi, Hojjat Casals Terré, Jasmina|||0000-0002-1368-3950 |
| author |
Mohammadi, Mahdi |
| author_facet |
Mohammadi, Mahdi Madadi, Hojjat Casals Terré, Jasmina|||0000-0002-1368-3950 |
| author_role |
author |
| author2 |
Madadi, Hojjat Casals Terré, Jasmina|||0000-0002-1368-3950 |
| author2_role |
author author |
| dc.subject.none.fl_str_mv |
Biophysics Blood plasma Microfluidics Electroosmosis Fluidic devices Haemodynamics Microscale flows Plasma channeling Biofísica Plasma sanguini Microfluídica Àrees temàtiques de la UPC::Física |
| topic |
Biophysics Blood plasma Microfluidics Electroosmosis Fluidic devices Haemodynamics Microscale flows Plasma channeling Biofísica Plasma sanguini Microfluídica Àrees temàtiques de la UPC::Física |
| description |
Copyright 2015 AIP Publishing. This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015 2015-09-11 2016 2016-04-21 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 AM http://purl.org/coar/version/c_ab4af688f83e57aa |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2117/86065 https://dx.doi.org/10.1063/1.4930865 |
| url |
https://hdl.handle.net/2117/86065 https://dx.doi.org/10.1063/1.4930865 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
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application/pdf |
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reponame:UPCommons. Portal del coneixement obert de la UPC instname:Universitat Politècnica de Catalunya (UPC) |
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Universitat Politècnica de Catalunya (UPC) |
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UPCommons. Portal del coneixement obert de la UPC |
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UPCommons. Portal del coneixement obert de la UPC |
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1869402945359970304 |
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15,301603 |