Perspectives of the Application of Non-Steroidal Anti-Inflammatory Drugs in Cancer Therapy: Attempts to Overcome Their Unfavorable Side Effects

Non-steroidal anti-inflammatory drugs (NSAIDs) express anti-tumoral activity mainly by blocking cyclooxygenase-2 involved in the synthesis of prostaglandins. Therefore, in the last few decades, many have attempted to explore the possibilities of applying this group of drugs as effective agents for t...

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Autores: Thiruchenthooran, Vaikunthavasan, Gliszczynska, Anna, Sánchez-López, E. (Elena)
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/202987
Acceso en línea:https://hdl.handle.net/2445/202987
Access Level:acceso abierto
Palabra clave:Quimioteràpia del càncer
Antiinflamatoris no esteroïdals
Cancer chemotherapy
Nonsteroidal anti-inflammatory agents
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spelling Perspectives of the Application of Non-Steroidal Anti-Inflammatory Drugs in Cancer Therapy: Attempts to Overcome Their Unfavorable Side EffectsThiruchenthooran, VaikunthavasanGliszczynska, AnnaSánchez-López, E. (Elena)Quimioteràpia del càncerAntiinflamatoris no esteroïdalsCancer chemotherapyNonsteroidal anti-inflammatory agentsNon-steroidal anti-inflammatory drugs (NSAIDs) express anti-tumoral activity mainly by blocking cyclooxygenase-2 involved in the synthesis of prostaglandins. Therefore, in the last few decades, many have attempted to explore the possibilities of applying this group of drugs as effective agents for the inhibition of neoplastic processes. This review summarizes the evidence presented in the literature regarding the anti-tumoral actions of NSAIDs used as monotherapies as well as in combination with conventional chemotherapeutics and natural products. In several clinical trials, it was proven that combinations of NSAIDs and chemotherapeutic drugs (CTDs) were able to obtain suitable results. The combination with phospholipids may resolve the adverse effects of NSAIDs and deliver derivatives with increased antitumor activity, whereas hybrids with terpenoids exhibit superior activity against their parent drugs or physical mixtures. Therefore, the application of NSAIDs in cancer therapy seems to be still an open chapter and requires deep and careful evaluation. The literature’s data indicate the possibilities of re-purposing anti-inflammatory drugs currently approved for cancer treatmentsMDPI2023202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion24 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/202987Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/cancers15020475Cancers, 2023, vol. 15https://doi.org/10.3390/cancers15020475cc-by (c) Thiruchenthooran, Vaikunthavasan et al, 2023http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2029872026-05-29T05:05:01Z
dc.title.none.fl_str_mv Perspectives of the Application of Non-Steroidal Anti-Inflammatory Drugs in Cancer Therapy: Attempts to Overcome Their Unfavorable Side Effects
title Perspectives of the Application of Non-Steroidal Anti-Inflammatory Drugs in Cancer Therapy: Attempts to Overcome Their Unfavorable Side Effects
spellingShingle Perspectives of the Application of Non-Steroidal Anti-Inflammatory Drugs in Cancer Therapy: Attempts to Overcome Their Unfavorable Side Effects
Thiruchenthooran, Vaikunthavasan
Quimioteràpia del càncer
Antiinflamatoris no esteroïdals
Cancer chemotherapy
Nonsteroidal anti-inflammatory agents
title_short Perspectives of the Application of Non-Steroidal Anti-Inflammatory Drugs in Cancer Therapy: Attempts to Overcome Their Unfavorable Side Effects
title_full Perspectives of the Application of Non-Steroidal Anti-Inflammatory Drugs in Cancer Therapy: Attempts to Overcome Their Unfavorable Side Effects
title_fullStr Perspectives of the Application of Non-Steroidal Anti-Inflammatory Drugs in Cancer Therapy: Attempts to Overcome Their Unfavorable Side Effects
title_full_unstemmed Perspectives of the Application of Non-Steroidal Anti-Inflammatory Drugs in Cancer Therapy: Attempts to Overcome Their Unfavorable Side Effects
title_sort Perspectives of the Application of Non-Steroidal Anti-Inflammatory Drugs in Cancer Therapy: Attempts to Overcome Their Unfavorable Side Effects
dc.creator.none.fl_str_mv Thiruchenthooran, Vaikunthavasan
Gliszczynska, Anna
Sánchez-López, E. (Elena)
author Thiruchenthooran, Vaikunthavasan
author_facet Thiruchenthooran, Vaikunthavasan
Gliszczynska, Anna
Sánchez-López, E. (Elena)
author_role author
author2 Gliszczynska, Anna
Sánchez-López, E. (Elena)
author2_role author
author
dc.subject.none.fl_str_mv Quimioteràpia del càncer
Antiinflamatoris no esteroïdals
Cancer chemotherapy
Nonsteroidal anti-inflammatory agents
topic Quimioteràpia del càncer
Antiinflamatoris no esteroïdals
Cancer chemotherapy
Nonsteroidal anti-inflammatory agents
description Non-steroidal anti-inflammatory drugs (NSAIDs) express anti-tumoral activity mainly by blocking cyclooxygenase-2 involved in the synthesis of prostaglandins. Therefore, in the last few decades, many have attempted to explore the possibilities of applying this group of drugs as effective agents for the inhibition of neoplastic processes. This review summarizes the evidence presented in the literature regarding the anti-tumoral actions of NSAIDs used as monotherapies as well as in combination with conventional chemotherapeutics and natural products. In several clinical trials, it was proven that combinations of NSAIDs and chemotherapeutic drugs (CTDs) were able to obtain suitable results. The combination with phospholipids may resolve the adverse effects of NSAIDs and deliver derivatives with increased antitumor activity, whereas hybrids with terpenoids exhibit superior activity against their parent drugs or physical mixtures. Therefore, the application of NSAIDs in cancer therapy seems to be still an open chapter and requires deep and careful evaluation. The literature’s data indicate the possibilities of re-purposing anti-inflammatory drugs currently approved for cancer treatments
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/202987
url https://hdl.handle.net/2445/202987
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/cancers15020475
Cancers, 2023, vol. 15
https://doi.org/10.3390/cancers15020475
dc.rights.none.fl_str_mv cc-by (c) Thiruchenthooran, Vaikunthavasan et al, 2023
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Thiruchenthooran, Vaikunthavasan et al, 2023
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 24 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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