Relationship between jumping to conclusions and clinical outcomes in people at clinical high-risk for psychosis

Background Psychosis is associated with a reasoning bias, which manifests as a tendency to 'jump to conclusions'. We examined this bias in people at clinical high-risk for psychosis (CHR) and investigated its relationship with their clinical outcomes. Methods In total, 303 CHR subjects and...

Descripción completa

Detalles Bibliográficos
Autores: Catalán Alcántara, Ana, Tognin, Stefania, Kempton, Matthew J., Stahl, Daniel, Salazar de Pablo, Gonzalo, Nelson, Barnaby, Pantelis, Christos, Riecher-Rössler, Anita, Bressan, Rodrigo, Barrantes Vidal, Neus, Krebs, Marie-Odile, Nordentoft, Merete, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P. F., Van Os, Jim, De Haan, Lieuwe, Van der Gaag, Mark, Valmaggia, Lucia R., McGuire, Philip
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/57740
Acceso en línea:http://hdl.handle.net/10810/57740
Access Level:acceso abierto
Palabra clave:functioning
psychosis
transition to psychosis
ultra high-risk
reasoning biases
delusional conviction
schizophrenia
individuals
scale
reliability
mechanisms
symptoms
validity
Descripción
Sumario:Background Psychosis is associated with a reasoning bias, which manifests as a tendency to 'jump to conclusions'. We examined this bias in people at clinical high-risk for psychosis (CHR) and investigated its relationship with their clinical outcomes. Methods In total, 303 CHR subjects and 57 healthy controls (HC) were included. Both groups were assessed at baseline, and after 1 and 2 years. A 'beads' task was used to assess reasoning bias. Symptoms and level of functioning were assessed using the Comprehensive Assessment of At-Risk Mental States scale (CAARMS) and the Global Assessment of Functioning (GAF), respectively. During follow up, 58 (16.1%) of the CHR group developed psychosis (CHR-T), and 245 did not (CHR-NT). Logistic regressions, multilevel mixed models, and Cox regression were used to analyse the relationship between reasoning bias and transition to psychosis and level of functioning, at each time point. Results There was no association between reasoning bias at baseline and the subsequent onset of psychosis. However, when assessed after the transition to psychosis, CHR-T participants showed a greater tendency to jump to conclusions than CHR-NT and HC participants (55, 17, 17%; chi 2 = 8.13, p = 0.012). There was a significant association between jumping to conclusions (JTC) at baseline and a reduced level of functioning at 2-year follow-up in the CHR group after adjusting for transition, gender, ethnicity, age, and IQ. Conclusions In CHR participants, JTC at baseline was associated with adverse functioning at the follow-up. Interventions designed to improve JTC could be beneficial in the CHR population.

Similares en LA Referencia