Coordination of cell proliferation with developmental programs in Arabidopsis

Tesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Biología Molecular. Fecha de Lectura: 07-06-2022

Detalles Bibliográficos
Autor: Echevarría Zomeño, Clara
Tipo de recurso: tesis doctoral
Fecha de publicación:2022
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/703839
Acceso en línea:http://hdl.handle.net/10486/703839
Access Level:acceso abierto
Palabra clave:Arabidopsis thaliana
Biología y Biomedicina / Biología
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spelling Coordination of cell proliferation with developmental programs in ArabidopsisCoordinación de la proliferación celular con programas del desarrollo en ArabidopsisEchevarría Zomeño, ClaraArabidopsis thalianaBiología y Biomedicina / BiologíaTesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Biología Molecular. Fecha de Lectura: 07-06-2022Postembryonic development in plants constitutes a unique situation to study how the behavior of different cell types is coordinated to form all organs continuously throughout the life of the organism. Specifically, the Arabidopsis root apical meristem (RAM) is an organ, rich in proliferating cells of few cell types organized in concentric layers and with a gradual longitudinal transition from stem cells to differentiated tissues. Using a three-color cell cycle marker developed in our laboratory alongside other experimental strategies, we have begun to characterize cell cycle dynamics in the RAM. We have found that the total cell cycle length and also individual phases change depending on the tissue layers and, most notably, throughout the developmental trajectory. The G1 duration can vary between 1-2 hours in cells about to leave the root meristem and more than 20 hours in cells close to the stem cell niche, following a proximal-distal gradient that coincides with concentrations of the well-known stem cell regulator PLETHORA (PLT). Here, we have uncovered a link between developmental cues and cell cycle genes. In the regulatory network proposed, PLT proteins act upon RETINOBLASTOMA RELATED 1 (RBR1) phosphorylation by the CDK inhibitor KRP5, lengthening G1 duration by inhibiting G1/S transitionGutierrez Armenta, CrisantoDesvoyes, BénédicteDepartamento de Biología MolecularFacultad de CienciasUAM-CSIC. Centro de Biología Molecular Severo Ochoa (CBM)20222022-06-07doctoral thesishttp://purl.org/coar/resource_type/c_db06NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/doctoralThesisapplication/pdfhttp://hdl.handle.net/10486/703839reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7038392026-06-23T12:46:27Z
dc.title.none.fl_str_mv Coordination of cell proliferation with developmental programs in Arabidopsis
Coordinación de la proliferación celular con programas del desarrollo en Arabidopsis
title Coordination of cell proliferation with developmental programs in Arabidopsis
spellingShingle Coordination of cell proliferation with developmental programs in Arabidopsis
Echevarría Zomeño, Clara
Arabidopsis thaliana
Biología y Biomedicina / Biología
title_short Coordination of cell proliferation with developmental programs in Arabidopsis
title_full Coordination of cell proliferation with developmental programs in Arabidopsis
title_fullStr Coordination of cell proliferation with developmental programs in Arabidopsis
title_full_unstemmed Coordination of cell proliferation with developmental programs in Arabidopsis
title_sort Coordination of cell proliferation with developmental programs in Arabidopsis
dc.creator.none.fl_str_mv Echevarría Zomeño, Clara
author Echevarría Zomeño, Clara
author_facet Echevarría Zomeño, Clara
author_role author
dc.contributor.none.fl_str_mv Gutierrez Armenta, Crisanto
Desvoyes, Bénédicte
Departamento de Biología Molecular
Facultad de Ciencias
UAM-CSIC. Centro de Biología Molecular Severo Ochoa (CBM)
dc.subject.none.fl_str_mv Arabidopsis thaliana
Biología y Biomedicina / Biología
topic Arabidopsis thaliana
Biología y Biomedicina / Biología
description Tesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Biología Molecular. Fecha de Lectura: 07-06-2022
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-06-07
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/703839
url http://hdl.handle.net/10486/703839
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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