Effects of larval exposure to sublethal doses of ivermectin on adult fitness and susceptibility to ivermectin in Anopheles gambiae s.s
Background The effects of ivermectin (endectocide) on mosquito survival make it a potential new malaria vector control tool. The drug can be administered to mosquito disease vectors through blood hosts that include humans and livestock. Its increased use may cause contamination of larval habitats, e...
| Autores: | , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2023 |
| País: | España |
| Recursos: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/67811 |
| Acesso em linha: | https://hdl.handle.net/10171/67811 |
| Access Level: | acceso abierto |
| Palavra-chave: | Área de Biomedicina Ivermectin Mosquito larvae Adult ftness Anopheles gambiae s.s. |
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Effects of larval exposure to sublethal doses of ivermectin on adult fitness and susceptibility to ivermectin in Anopheles gambiae s.sKiuru, C. (Caroline)|||/items/84637570-9cf3-42f2-b765-a324646ec54aOminde, K. (Kelly)|||/items/1a18e21d-ac0c-4ec1-bc20-d595d4c56aaeMuturi, M. (Martha)|||/items/64934a0f-378c-4cc8-9943-01c33b046b09Babu, L. (Lawrence)|||/items/94f72381-a676-43dd-a98e-d9c4a48261aaWanjiku, C. (Caroline)|||/items/75778255-1595-43a4-aeab-b6b3be2c6e7bChaccour-Díaz, C.J. (Carlos Javier)|||/items/94d62c6d-ac64-42ab-b253-feb88e916983Maia, M. (Marta)|||/items/4084b887-2912-4956-8a12-b23038b74cb8Área de BiomedicinaIvermectinMosquito larvaeAdult ftnessAnopheles gambiae s.s.Background The effects of ivermectin (endectocide) on mosquito survival make it a potential new malaria vector control tool. The drug can be administered to mosquito disease vectors through blood hosts that include humans and livestock. Its increased use may cause contamination of larval habitats, either directly through livestock excreta or indirectly through leaching or run-off from contaminated soil, albeit in sublethal doses. However, the effects of such exposure on immature stages and the subsequent adults that emerge are poorly understood. This study was undertaken to evaluate the impact of ivermectin exposure on Anopheles gambiae s.s. larvae and its effects on fitness and susceptibility to ivermectin in the emerging adults. Methods Laboratory-reared An. gambiae s.s. (Kilifi strain) larvae were exposed to five different ivermectin concentrations; 0, 0.00001, 0.0001, 0.001, and 0.01 ppm, and larval survival was monitored to determine the appropriate sublethal dose. Concentrations with survival > 50% (0.00001 and 0.0001 ppm) were selected and used as the sub-lethal doses. The fecundity, fertility, and susceptibility to ivermectin of adults emerging after larval exposure to the sub-lethal doses were examined. Results Overall, exposure of An. gambiae s.s. aquatic stages to ivermectin caused a dose-dependent reduction in larval survival irrespective of the stage at which the larvae were exposed. Exposure to ivermectin in the larval stage did not have an effect on either the number of eggs laid or the hatch rate. However, exposure of first/second-instar larvae to 0.0001 ppm and third/fourth-instar larvae to 0.001 ppm of ivermectin reduced the time taken to oviposition. Additionally, exposure to ivermectin in the larval stage did not affect susceptibility of the emerging adults to the drug. Conclusions This study shows that contamination of larval habitats with ivermectin affects An. gambiae s.s. larval survival and could potentially have an impact on public health. However, there are no carry-over effects on the fecundity, fertility, and susceptibility of the emerging adults to ivermectin. In addition, this study shows that environmental exposure to ivermectin in the larval habitats is unlikely to compromise the efficacy of ivermectin in the emerging adults.Dadun. Depósito Académico Digital Universidad de Navarra20232023-11-0620232023-01-0120232023-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/67811reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/678112026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Effects of larval exposure to sublethal doses of ivermectin on adult fitness and susceptibility to ivermectin in Anopheles gambiae s.s |
| title |
Effects of larval exposure to sublethal doses of ivermectin on adult fitness and susceptibility to ivermectin in Anopheles gambiae s.s |
| spellingShingle |
Effects of larval exposure to sublethal doses of ivermectin on adult fitness and susceptibility to ivermectin in Anopheles gambiae s.s Kiuru, C. (Caroline)|||/items/84637570-9cf3-42f2-b765-a324646ec54a Área de Biomedicina Ivermectin Mosquito larvae Adult ftness Anopheles gambiae s.s. |
| title_short |
Effects of larval exposure to sublethal doses of ivermectin on adult fitness and susceptibility to ivermectin in Anopheles gambiae s.s |
| title_full |
Effects of larval exposure to sublethal doses of ivermectin on adult fitness and susceptibility to ivermectin in Anopheles gambiae s.s |
| title_fullStr |
Effects of larval exposure to sublethal doses of ivermectin on adult fitness and susceptibility to ivermectin in Anopheles gambiae s.s |
| title_full_unstemmed |
Effects of larval exposure to sublethal doses of ivermectin on adult fitness and susceptibility to ivermectin in Anopheles gambiae s.s |
| title_sort |
Effects of larval exposure to sublethal doses of ivermectin on adult fitness and susceptibility to ivermectin in Anopheles gambiae s.s |
| dc.creator.none.fl_str_mv |
Kiuru, C. (Caroline)|||/items/84637570-9cf3-42f2-b765-a324646ec54a Ominde, K. (Kelly)|||/items/1a18e21d-ac0c-4ec1-bc20-d595d4c56aae Muturi, M. (Martha)|||/items/64934a0f-378c-4cc8-9943-01c33b046b09 Babu, L. (Lawrence)|||/items/94f72381-a676-43dd-a98e-d9c4a48261aa Wanjiku, C. (Caroline)|||/items/75778255-1595-43a4-aeab-b6b3be2c6e7b Chaccour-Díaz, C.J. (Carlos Javier)|||/items/94d62c6d-ac64-42ab-b253-feb88e916983 Maia, M. (Marta)|||/items/4084b887-2912-4956-8a12-b23038b74cb8 |
| author |
Kiuru, C. (Caroline)|||/items/84637570-9cf3-42f2-b765-a324646ec54a |
| author_facet |
Kiuru, C. (Caroline)|||/items/84637570-9cf3-42f2-b765-a324646ec54a Ominde, K. (Kelly)|||/items/1a18e21d-ac0c-4ec1-bc20-d595d4c56aae Muturi, M. (Martha)|||/items/64934a0f-378c-4cc8-9943-01c33b046b09 Babu, L. (Lawrence)|||/items/94f72381-a676-43dd-a98e-d9c4a48261aa Wanjiku, C. (Caroline)|||/items/75778255-1595-43a4-aeab-b6b3be2c6e7b Chaccour-Díaz, C.J. (Carlos Javier)|||/items/94d62c6d-ac64-42ab-b253-feb88e916983 Maia, M. (Marta)|||/items/4084b887-2912-4956-8a12-b23038b74cb8 |
| author_role |
author |
| author2 |
Ominde, K. (Kelly)|||/items/1a18e21d-ac0c-4ec1-bc20-d595d4c56aae Muturi, M. (Martha)|||/items/64934a0f-378c-4cc8-9943-01c33b046b09 Babu, L. (Lawrence)|||/items/94f72381-a676-43dd-a98e-d9c4a48261aa Wanjiku, C. (Caroline)|||/items/75778255-1595-43a4-aeab-b6b3be2c6e7b Chaccour-Díaz, C.J. (Carlos Javier)|||/items/94d62c6d-ac64-42ab-b253-feb88e916983 Maia, M. (Marta)|||/items/4084b887-2912-4956-8a12-b23038b74cb8 |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Área de Biomedicina Ivermectin Mosquito larvae Adult ftness Anopheles gambiae s.s. |
| topic |
Área de Biomedicina Ivermectin Mosquito larvae Adult ftness Anopheles gambiae s.s. |
| description |
Background The effects of ivermectin (endectocide) on mosquito survival make it a potential new malaria vector control tool. The drug can be administered to mosquito disease vectors through blood hosts that include humans and livestock. Its increased use may cause contamination of larval habitats, either directly through livestock excreta or indirectly through leaching or run-off from contaminated soil, albeit in sublethal doses. However, the effects of such exposure on immature stages and the subsequent adults that emerge are poorly understood. This study was undertaken to evaluate the impact of ivermectin exposure on Anopheles gambiae s.s. larvae and its effects on fitness and susceptibility to ivermectin in the emerging adults. Methods Laboratory-reared An. gambiae s.s. (Kilifi strain) larvae were exposed to five different ivermectin concentrations; 0, 0.00001, 0.0001, 0.001, and 0.01 ppm, and larval survival was monitored to determine the appropriate sublethal dose. Concentrations with survival > 50% (0.00001 and 0.0001 ppm) were selected and used as the sub-lethal doses. The fecundity, fertility, and susceptibility to ivermectin of adults emerging after larval exposure to the sub-lethal doses were examined. Results Overall, exposure of An. gambiae s.s. aquatic stages to ivermectin caused a dose-dependent reduction in larval survival irrespective of the stage at which the larvae were exposed. Exposure to ivermectin in the larval stage did not have an effect on either the number of eggs laid or the hatch rate. However, exposure of first/second-instar larvae to 0.0001 ppm and third/fourth-instar larvae to 0.001 ppm of ivermectin reduced the time taken to oviposition. Additionally, exposure to ivermectin in the larval stage did not affect susceptibility of the emerging adults to the drug. Conclusions This study shows that contamination of larval habitats with ivermectin affects An. gambiae s.s. larval survival and could potentially have an impact on public health. However, there are no carry-over effects on the fecundity, fertility, and susceptibility of the emerging adults to ivermectin. In addition, this study shows that environmental exposure to ivermectin in the larval habitats is unlikely to compromise the efficacy of ivermectin in the emerging adults. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2023-11-06 2023 2023-01-01 2023 2023-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/67811 |
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https://hdl.handle.net/10171/67811 |
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Inglés eng |
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Inglés |
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eng |
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open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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