Cholinergic Modulation of Stimulus-Specific Adaptation in the Inferior Colliculus

[EN] Neural encoding of an ever-changing acoustic environment is a complex and demanding process that depends on modulation by neuro-active substances. Some neurons of the inferior colliculus (IC) exhibit “stimulus-specific adaptation” (SSA), i.e., a decrease in their response to a repetitive sound,...

Descripción completa

Detalles Bibliográficos
Autores: Aguilar Ayala, Yaneri, Malmierca, Manuel S.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/145535
Acceso en línea:http://hdl.handle.net/10366/145535
Access Level:acceso abierto
Palabra clave:Acetylcholine
Attention
Auditory
Micriontophoresis
Neuromodulators
SSA
3205.07 Neurología
id ES_06c300358cc357d3fa0dae1b97c38fcd
oai_identifier_str oai:gredos.usal.es:10366/145535
network_acronym_str ES
network_name_str España
repository_id_str
spelling Cholinergic Modulation of Stimulus-Specific Adaptation in the Inferior ColliculusAguilar Ayala, YaneriMalmierca, Manuel S.AcetylcholineAttentionAuditoryMicriontophoresisNeuromodulatorsSSA3205.07 Neurología[EN] Neural encoding of an ever-changing acoustic environment is a complex and demanding process that depends on modulation by neuro-active substances. Some neurons of the inferior colliculus (IC) exhibit “stimulus-specific adaptation” (SSA), i.e., a decrease in their response to a repetitive sound, but not to a rare one. Previous studies have demonstrated that acetylcholine (ACh) alters the frequency response areas of auditory neurons and therefore is important in the encoding of spectral information. Here, we address how microion-tophoretic application of ACh modulates SSA in the IC of the anesthetized rat. We found that ACh decreased SSA in IC eurons by increasing the response to the repetitive tone. This effect was mainly mediated by muscarinic receptors. The strength of the cholinergic modulation depended on the baseline SSA level, exerting its greatest effect on neurons with intermediate SSA responses across IC subdivisions. Our data demonstrate that the increased availability of ACh exerts transient functional changes in partially adapting IC neurons, enhancing the sensory encoding of the ongoing stimulation. This effect potentially contributes to the propagation of ascending sensory-evoked afferent activity through the thalamus en route to the cortex.Journal of Neuroscience202120212015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10366/145535reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1455352026-06-07T06:28:51Z
dc.title.none.fl_str_mv Cholinergic Modulation of Stimulus-Specific Adaptation in the Inferior Colliculus
title Cholinergic Modulation of Stimulus-Specific Adaptation in the Inferior Colliculus
spellingShingle Cholinergic Modulation of Stimulus-Specific Adaptation in the Inferior Colliculus
Aguilar Ayala, Yaneri
Acetylcholine
Attention
Auditory
Micriontophoresis
Neuromodulators
SSA
3205.07 Neurología
title_short Cholinergic Modulation of Stimulus-Specific Adaptation in the Inferior Colliculus
title_full Cholinergic Modulation of Stimulus-Specific Adaptation in the Inferior Colliculus
title_fullStr Cholinergic Modulation of Stimulus-Specific Adaptation in the Inferior Colliculus
title_full_unstemmed Cholinergic Modulation of Stimulus-Specific Adaptation in the Inferior Colliculus
title_sort Cholinergic Modulation of Stimulus-Specific Adaptation in the Inferior Colliculus
dc.creator.none.fl_str_mv Aguilar Ayala, Yaneri
Malmierca, Manuel S.
author Aguilar Ayala, Yaneri
author_facet Aguilar Ayala, Yaneri
Malmierca, Manuel S.
author_role author
author2 Malmierca, Manuel S.
author2_role author
dc.subject.none.fl_str_mv Acetylcholine
Attention
Auditory
Micriontophoresis
Neuromodulators
SSA
3205.07 Neurología
topic Acetylcholine
Attention
Auditory
Micriontophoresis
Neuromodulators
SSA
3205.07 Neurología
description [EN] Neural encoding of an ever-changing acoustic environment is a complex and demanding process that depends on modulation by neuro-active substances. Some neurons of the inferior colliculus (IC) exhibit “stimulus-specific adaptation” (SSA), i.e., a decrease in their response to a repetitive sound, but not to a rare one. Previous studies have demonstrated that acetylcholine (ACh) alters the frequency response areas of auditory neurons and therefore is important in the encoding of spectral information. Here, we address how microion-tophoretic application of ACh modulates SSA in the IC of the anesthetized rat. We found that ACh decreased SSA in IC eurons by increasing the response to the repetitive tone. This effect was mainly mediated by muscarinic receptors. The strength of the cholinergic modulation depended on the baseline SSA level, exerting its greatest effect on neurons with intermediate SSA responses across IC subdivisions. Our data demonstrate that the increased availability of ACh exerts transient functional changes in partially adapting IC neurons, enhancing the sensory encoding of the ongoing stimulation. This effect potentially contributes to the propagation of ascending sensory-evoked afferent activity through the thalamus en route to the cortex.
publishDate 2015
dc.date.none.fl_str_mv 2015
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/145535
url http://hdl.handle.net/10366/145535
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Journal of Neuroscience
publisher.none.fl_str_mv Journal of Neuroscience
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869402937584779264
score 15,301603

Similares en LA Referencia