National temporal trend analysis of infective endocarditis among patients infected with HIV in Spain (1997–2014): A retrospective study

Producción Científica

Detalles Bibliográficos
Autores: Muñoz Moreno, María Fe, Ryan, Pablo, Álvaro Meca, Alejandro, Valencia, Jorge, Tamayo Gómez, Eduardo, Resino García, Salvador
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/55861
Acceso en línea:https://doi.org/10.3390/jcm8081167
https://uvadoc.uva.es/handle/10324/55861
Access Level:acceso abierto
Palabra clave:AIDS (Disease)
SIDA (Enfermedad)
Infective endocarditis
Endocarditis infecciosa
Etiology
Etiología
3202 Epidemiología
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spelling National temporal trend analysis of infective endocarditis among patients infected with HIV in Spain (1997–2014): A retrospective studyMuñoz Moreno, María FeRyan, PabloÁlvaro Meca, AlejandroValencia, JorgeTamayo Gómez, EduardoResino García, SalvadorAIDS (Disease)SIDA (Enfermedad)Infective endocarditisEndocarditis infecciosaEtiologyEtiología3202 EpidemiologíaProducción CientíficaBackground: People living with human immunodeficiency virus (HIV) (PLWH) form a vulnerable population for the onset of infective endocarditis (IE). We aimed to analyze the epidemiological trend of IE, as well as its microbiological characteristics, in PLWH during the combined antiretroviral therapy era in Spain. Methods: We performed a retrospective study (1997–2014) in PLWH with data obtained from the Spanish Minimum Basic Data Set. We selected 1800 hospital admissions with an IE diagnosis, which corresponded to 1439 patients. Results: We found significant downward trends in the periods 1997–1999 and 2008–2014 in the rate of hospital admissions with an IE diagnosis (from 21.8 to 3.8 events per 10,000 patients/year; p < 0.001), IE incidence (from 18.2 to 2.9 events per 10,000 patients/year; p < 0.001), and IE mortality (from 23.9 to 5.5 deaths per 100,000 patient-years; p < 0.001). The most frequent microorganisms involved were staphylococci (50%; 42.7% Staphylococcus aureus and 7.3% coagulase-negative staphylococci (CoNS)), followed by streptococci (9.3%), Gram-negative bacilli (8.3%), enterococci (3%), and fungus (1.4%). During the study period, we found a downward trend in the rates of CoNS (p < 0.001) and an upward trends in streptococci (p = 0.001), Gram-negative bacilli (p < 0.001), enterococci (p = 0.003), and fungus (p < 0.001) related to IE, mainly in 2008–2014. The rate of community-acquired IE showed a significant upward trend (p = 0.001), while the rate of health care-associated IE showed a significant downward trend (p < 0.001). Conclusions: The rates of hospital admissions, incidence, and mortality related to IE diagnosis in PLWH in Spain decreased from 1997 to 2014, while other changes in clinical characteristics, mode of acquisition, and pathogens occurred over this time.Instituto de Salud Carlos III (grant PI15/01451)Junta de Castilla y León (grant 773/A/13)Elsevier2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.3390/jcm8081167https://uvadoc.uva.es/handle/10324/55861reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://www.mdpi.com/2077-0383/8/8/1167info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:uvadoc.uva.es:10324/558612026-06-13T12:44:47Z
dc.title.none.fl_str_mv National temporal trend analysis of infective endocarditis among patients infected with HIV in Spain (1997–2014): A retrospective study
title National temporal trend analysis of infective endocarditis among patients infected with HIV in Spain (1997–2014): A retrospective study
spellingShingle National temporal trend analysis of infective endocarditis among patients infected with HIV in Spain (1997–2014): A retrospective study
Muñoz Moreno, María Fe
AIDS (Disease)
SIDA (Enfermedad)
Infective endocarditis
Endocarditis infecciosa
Etiology
Etiología
3202 Epidemiología
title_short National temporal trend analysis of infective endocarditis among patients infected with HIV in Spain (1997–2014): A retrospective study
title_full National temporal trend analysis of infective endocarditis among patients infected with HIV in Spain (1997–2014): A retrospective study
title_fullStr National temporal trend analysis of infective endocarditis among patients infected with HIV in Spain (1997–2014): A retrospective study
title_full_unstemmed National temporal trend analysis of infective endocarditis among patients infected with HIV in Spain (1997–2014): A retrospective study
title_sort National temporal trend analysis of infective endocarditis among patients infected with HIV in Spain (1997–2014): A retrospective study
dc.creator.none.fl_str_mv Muñoz Moreno, María Fe
Ryan, Pablo
Álvaro Meca, Alejandro
Valencia, Jorge
Tamayo Gómez, Eduardo
Resino García, Salvador
author Muñoz Moreno, María Fe
author_facet Muñoz Moreno, María Fe
Ryan, Pablo
Álvaro Meca, Alejandro
Valencia, Jorge
Tamayo Gómez, Eduardo
Resino García, Salvador
author_role author
author2 Ryan, Pablo
Álvaro Meca, Alejandro
Valencia, Jorge
Tamayo Gómez, Eduardo
Resino García, Salvador
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv AIDS (Disease)
SIDA (Enfermedad)
Infective endocarditis
Endocarditis infecciosa
Etiology
Etiología
3202 Epidemiología
topic AIDS (Disease)
SIDA (Enfermedad)
Infective endocarditis
Endocarditis infecciosa
Etiology
Etiología
3202 Epidemiología
description Producción Científica
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/jcm8081167
https://uvadoc.uva.es/handle/10324/55861
url https://doi.org/10.3390/jcm8081167
https://uvadoc.uva.es/handle/10324/55861
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.mdpi.com/2077-0383/8/8/1167
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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