Valoración neurocognitiva (experiencias anómalas del SELF) para la definición de grupos biológicamente válidos dentro de la esquizofrenia
The general objective of this thesis was to study the differences in neurocognitive functions (anomalous self-experiences) in schizophrenia and to assess their neurobiological basis, evaluating their relationship with parameters previously associated with the definition of biologically relevant subg...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2026 |
| País: | España |
| Institución: | Universidad de Valladolid |
| Repositorio: | UVaDOC. Repositorio Documental de la Universidad de Valladolid |
| OAI Identifier: | oai:uvadoc.uva.es:10324/83396 |
| Acceso en línea: | https://doi.org/10.35376/10324/83396 https://uvadoc.uva.es/handle/10324/83396 |
| Access Level: | acceso abierto |
| Palabra clave: | Esquizofrenia - Tratamiento Psychosis Esquizofrenia Self-experiences Biotipos 3211 Psiquiatría |
| Sumario: | The general objective of this thesis was to study the differences in neurocognitive functions (anomalous self-experiences) in schizophrenia and to assess their neurobiological basis, evaluating their relationship with parameters previously associated with the definition of biologically relevant subgroups within the schizophrenia syndrome, thereby contributing to its characterization. To achieve this, three specific objectives were proposed: 1)To adapt and validate the Inventory of Psychotic-Like Anomalous Self-Experiences (IPASE) from English into Spanish, enabling the assessment of psychosis-like anomalous self-experiences through a self-administered inventory; 2)To explore differences between segregated groups in terms of cognitive functions and clinical scores;3)To explore differences in cognitive functions between the segregated groups based on structural and functional connectivity variables, using global measures of brain network organization and modulation derived from graph theory. Taken together, the studies presented in this doctoral thesis have expanded the understanding of neurophysiological and neurocognitive alterations and the presence of ASEs (Anomalous Self-Experiences) in individuals with psychosis, contributing to the definition of biotypes within this syndrome. The results support the hypothesis that schizophrenia does not constitute a single clinical entity, but rather a set of diverse conditions that share certain clinical manifestations yet differ in their underlying mechanisms. In this context, new data-driven methodological approaches may emerge as more effective strategies to capture and understand the complexity and variability that characterize this mental disorder. |
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