PLA-PEG-Cholesterol biomimetic membrane for electrochemical sensing of antioxidants
Polymeric membranes exhibit unique and modulate transport properties when they are properly functionalised, which make them ideal for ions transport, molecules separation and molecules interactions. The present work proposes the design and fabrication of nanostructured membranes, composed by biodegr...
| Autores: | , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/399662 |
| Acceso en línea: | https://hdl.handle.net/2117/399662 https://dx.doi.org/10.1016/j.electacta.2023.143716 |
| Access Level: | acceso abierto |
| Palabra clave: | Polymers Poly(lactic acid) Poly(ethyleneglycol) Cholesterol Nanomembranes Antioxidant molecules Electrochemical detection Polímers Àrees temàtiques de la UPC::Enginyeria química |
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PLA-PEG-Cholesterol biomimetic membrane for electrochemical sensing of antioxidantsMadhani Mohammed Sadhakathullah, Ahammed Hussain|||0000-0002-8703-0450Paulo Mirasol, Sofia|||0000-0002-3802-8880Molina García, Brenda Guadalupe|||0000-0002-7723-5313Torras Costa, Juan|||0000-0001-8737-7609Armelín Diggroc, Elaine Aparecida|||0000-0002-0658-7696PolymersPoly(lactic acid)Poly(ethyleneglycol)CholesterolNanomembranesAntioxidant moleculesElectrochemical detectionPolímersÀrees temàtiques de la UPC::Enginyeria químicaPolymeric membranes exhibit unique and modulate transport properties when they are properly functionalised, which make them ideal for ions transport, molecules separation and molecules interactions. The present work proposes the design and fabrication of nanostructured membranes, composed by biodegradable poly(lactic acid) (PLA) and poly(ethylene glycol) (PEG), incorporating a lipophilic molecule (cholesterol) covalently bonded, were especially designed to provide even more application opportunities in sensors field. Electrochemical studies, by means of electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and square wave voltammetry (SWV), revealed important differences regarding the functionalised and non-functionalised PLA systems. PEG-cholesterol building block units showed a clear affinity with ascorbic acid (vitamin C) and Trolox® (a water-soluble analogue of vitamin E), both hydrophilic in nature, with a limit of detection capacity of 8.12 µM for AA and 3.53 µM for AA and Trolox, respectively, in aqueous salt solution. The bioinspired polymer may be used to incorporate antioxidant property that allow the design of anti-stress biosensors, electrodes for the detection of vitamin C or vitamin E in biomedical nutrition programs, among other applications.The authors thank the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement BioInspireSensing No 955643 for supporting this work. Authors also acknowledge the Agència de Gestió d'Ajuts Universitaris i de Recerca, AGAUR (Grant number: 2021 SGR 00387), by Generalitat de Catalunya (Spain), for the financial support of this research.Peer Reviewed20242024-02-0120242024-01-17journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/399662https://dx.doi.org/10.1016/j.electacta.2023.143716reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)InglésengEuropean Commission http://doi.org/10.13039/100010661 Horizon 2020 Framework Programme 955643 Multidisciplinary Training of Young Researchers in Novel Implantable Bio-inspired sensorsopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/3996622026-05-27T15:37:01Z |
| dc.title.none.fl_str_mv |
PLA-PEG-Cholesterol biomimetic membrane for electrochemical sensing of antioxidants |
| title |
PLA-PEG-Cholesterol biomimetic membrane for electrochemical sensing of antioxidants |
| spellingShingle |
PLA-PEG-Cholesterol biomimetic membrane for electrochemical sensing of antioxidants Madhani Mohammed Sadhakathullah, Ahammed Hussain|||0000-0002-8703-0450 Polymers Poly(lactic acid) Poly(ethyleneglycol) Cholesterol Nanomembranes Antioxidant molecules Electrochemical detection Polímers Àrees temàtiques de la UPC::Enginyeria química |
| title_short |
PLA-PEG-Cholesterol biomimetic membrane for electrochemical sensing of antioxidants |
| title_full |
PLA-PEG-Cholesterol biomimetic membrane for electrochemical sensing of antioxidants |
| title_fullStr |
PLA-PEG-Cholesterol biomimetic membrane for electrochemical sensing of antioxidants |
| title_full_unstemmed |
PLA-PEG-Cholesterol biomimetic membrane for electrochemical sensing of antioxidants |
| title_sort |
PLA-PEG-Cholesterol biomimetic membrane for electrochemical sensing of antioxidants |
| dc.creator.none.fl_str_mv |
Madhani Mohammed Sadhakathullah, Ahammed Hussain|||0000-0002-8703-0450 Paulo Mirasol, Sofia|||0000-0002-3802-8880 Molina García, Brenda Guadalupe|||0000-0002-7723-5313 Torras Costa, Juan|||0000-0001-8737-7609 Armelín Diggroc, Elaine Aparecida|||0000-0002-0658-7696 |
| author |
Madhani Mohammed Sadhakathullah, Ahammed Hussain|||0000-0002-8703-0450 |
| author_facet |
Madhani Mohammed Sadhakathullah, Ahammed Hussain|||0000-0002-8703-0450 Paulo Mirasol, Sofia|||0000-0002-3802-8880 Molina García, Brenda Guadalupe|||0000-0002-7723-5313 Torras Costa, Juan|||0000-0001-8737-7609 Armelín Diggroc, Elaine Aparecida|||0000-0002-0658-7696 |
| author_role |
author |
| author2 |
Paulo Mirasol, Sofia|||0000-0002-3802-8880 Molina García, Brenda Guadalupe|||0000-0002-7723-5313 Torras Costa, Juan|||0000-0001-8737-7609 Armelín Diggroc, Elaine Aparecida|||0000-0002-0658-7696 |
| author2_role |
author author author author |
| dc.subject.none.fl_str_mv |
Polymers Poly(lactic acid) Poly(ethyleneglycol) Cholesterol Nanomembranes Antioxidant molecules Electrochemical detection Polímers Àrees temàtiques de la UPC::Enginyeria química |
| topic |
Polymers Poly(lactic acid) Poly(ethyleneglycol) Cholesterol Nanomembranes Antioxidant molecules Electrochemical detection Polímers Àrees temàtiques de la UPC::Enginyeria química |
| description |
Polymeric membranes exhibit unique and modulate transport properties when they are properly functionalised, which make them ideal for ions transport, molecules separation and molecules interactions. The present work proposes the design and fabrication of nanostructured membranes, composed by biodegradable poly(lactic acid) (PLA) and poly(ethylene glycol) (PEG), incorporating a lipophilic molecule (cholesterol) covalently bonded, were especially designed to provide even more application opportunities in sensors field. Electrochemical studies, by means of electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and square wave voltammetry (SWV), revealed important differences regarding the functionalised and non-functionalised PLA systems. PEG-cholesterol building block units showed a clear affinity with ascorbic acid (vitamin C) and Trolox® (a water-soluble analogue of vitamin E), both hydrophilic in nature, with a limit of detection capacity of 8.12 µM for AA and 3.53 µM for AA and Trolox, respectively, in aqueous salt solution. The bioinspired polymer may be used to incorporate antioxidant property that allow the design of anti-stress biosensors, electrodes for the detection of vitamin C or vitamin E in biomedical nutrition programs, among other applications. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2024-02-01 2024 2024-01-17 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2117/399662 https://dx.doi.org/10.1016/j.electacta.2023.143716 |
| url |
https://hdl.handle.net/2117/399662 https://dx.doi.org/10.1016/j.electacta.2023.143716 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
European Commission http://doi.org/10.13039/100010661 Horizon 2020 Framework Programme 955643 Multidisciplinary Training of Young Researchers in Novel Implantable Bio-inspired sensors |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
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reponame:UPCommons. Portal del coneixement obert de la UPC instname:Universitat Politècnica de Catalunya (UPC) |
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Universitat Politècnica de Catalunya (UPC) |
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UPCommons. Portal del coneixement obert de la UPC |
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UPCommons. Portal del coneixement obert de la UPC |
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15.300719 |