Printable and Tunable Bioresin with Strategically Decorated Molecular Structures

[EN] As personalized medicine rapidly evolves, there is a critical demand for advanced biocompatible materials surpassing current additive manufacturing capabilities. This study presents a novel printable bioresin engineered with tunable mechanical, thermal, and biocompatibility properties through s...

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Autores: Rufo-Martín, Celia, Díaz-Álvarez, José, Miguélez, Henar, Youssef, George, Infante-García, Diego|||0000-0001-6010-2031
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/214140
Acceso en línea:https://riunet.upv.es/handle/10251/214140
Access Level:acceso abierto
Palabra clave:Advanced polymer nanocomposites
Bio 3D printing
Molecular decorations
Patient-specific implants
Personalized medicine
INGENIERIA MECANICA
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dc.title.none.fl_str_mv Printable and Tunable Bioresin with Strategically Decorated Molecular Structures
title Printable and Tunable Bioresin with Strategically Decorated Molecular Structures
spellingShingle Printable and Tunable Bioresin with Strategically Decorated Molecular Structures
Rufo-Martín, Celia
Advanced polymer nanocomposites
Bio 3D printing
Molecular decorations
Patient-specific implants
Personalized medicine
INGENIERIA MECANICA
title_short Printable and Tunable Bioresin with Strategically Decorated Molecular Structures
title_full Printable and Tunable Bioresin with Strategically Decorated Molecular Structures
title_fullStr Printable and Tunable Bioresin with Strategically Decorated Molecular Structures
title_full_unstemmed Printable and Tunable Bioresin with Strategically Decorated Molecular Structures
title_sort Printable and Tunable Bioresin with Strategically Decorated Molecular Structures
dc.creator.none.fl_str_mv Rufo-Martín, Celia
Díaz-Álvarez, José
Miguélez, Henar
Youssef, George
Infante-García, Diego|||0000-0001-6010-2031
author Rufo-Martín, Celia
author_facet Rufo-Martín, Celia
Díaz-Álvarez, José
Miguélez, Henar
Youssef, George
Infante-García, Diego|||0000-0001-6010-2031
author_role author
author2 Díaz-Álvarez, José
Miguélez, Henar
Youssef, George
Infante-García, Diego|||0000-0001-6010-2031
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Ingeniería Mecánica y de Materiales
Instituto Universitario de Investigación Concertado de Ingeniería Mecánica y Biomecánica
Escuela Técnica Superior de Ingeniería Industrial
Generalitat Valenciana
U.S. Department of Defense
Agencia Estatal de Investigación
National Science Foundation, EEUU
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Advanced polymer nanocomposites
Bio 3D printing
Molecular decorations
Patient-specific implants
Personalized medicine
INGENIERIA MECANICA
topic Advanced polymer nanocomposites
Bio 3D printing
Molecular decorations
Patient-specific implants
Personalized medicine
INGENIERIA MECANICA
description [EN] As personalized medicine rapidly evolves, there is a critical demand for advanced biocompatible materials surpassing current additive manufacturing capabilities. This study presents a novel printable bioresin engineered with tunable mechanical, thermal, and biocompatibility properties through strategic molecular modifications. The study introduces a new bioresin comprising methyl methacrylate (MMA), ethylene glycol dimethacrylate (EGDMA), and a photoinitiator, which is further enhanced by incorporating high molecular weight polymethyl methacrylate (PMMA) to improve biostability and mechanical performance. The integration of printable PMMA presents several synthesis and processing challenges, necessitating substantial modifications to the 3D printing process. Additionally, the bioresin is functionalized with antibacterial silver oxide and bone-growth-promoting hydroxyapatite at various weight ratios to extend its application further. The results demonstrate the agile printability of the novel bioresin and its potential for transformative impact in biomedical applications, offering a versatile material platform for additive manufacturing-enabled personalized medicine. This work highlights the adaptability of the novel printable bioresin for real-life applications and its capacity for multiscale structural tailoring, potentially achieving properties comparable to native tissues and extending beyond conventional additive manufacturing techniques.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/214140
url https://riunet.upv.es/handle/10251/214140
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PDC2021-121368-C21 IN PROCESS OPTIMIZATION OF TOOL LIFE IN INDUSTRIAL DRILLING OF HYBRID STACKS CFRP%2FMETAL
Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2020-112628RA-I00 DISEÑO INTEGRAL Y FABRICACION ADITIVA DE IMPLANTES POLIMERICOS PATIENT-SPECIFIC
Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2020-118480RB-C22 ANALISIS DE DEFECTOS EN LAMINADOS REFORZADOS CON FIBRAS DEBIDOS A PROCESOS DE FABRICACION Y EFECTO EN EL COMPORTAMIENTO A FATIGA
National Science Foundation, China https://doi.org/10.13039/100000001 2035663
Generalitat Valenciana https://doi.org/10.13039/501100003359 CIAPOS%2F2021%2F271
U.S. Department of Defense https://doi.org/10.13039/100000005 W911NF1410039
U.S. Department of Defense https://doi.org/10.13039/100000005 W911NF1810477
U.S. Department of Defense https://doi.org/10.13039/100000005 W911NF2310150
U.S. Department of Defense https://doi.org/10.13039/100000005 N00174-23-1-0009
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reserva de todos los derechos
http://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reserva de todos los derechos
http://rightsstatements.org/vocab/InC/1.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
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spelling Printable and Tunable Bioresin with Strategically Decorated Molecular StructuresRufo-Martín, CeliaDíaz-Álvarez, JoséMiguélez, HenarYoussef, GeorgeInfante-García, Diego|||0000-0001-6010-2031Advanced polymer nanocompositesBio 3D printingMolecular decorationsPatient-specific implantsPersonalized medicineINGENIERIA MECANICA[EN] As personalized medicine rapidly evolves, there is a critical demand for advanced biocompatible materials surpassing current additive manufacturing capabilities. This study presents a novel printable bioresin engineered with tunable mechanical, thermal, and biocompatibility properties through strategic molecular modifications. The study introduces a new bioresin comprising methyl methacrylate (MMA), ethylene glycol dimethacrylate (EGDMA), and a photoinitiator, which is further enhanced by incorporating high molecular weight polymethyl methacrylate (PMMA) to improve biostability and mechanical performance. The integration of printable PMMA presents several synthesis and processing challenges, necessitating substantial modifications to the 3D printing process. Additionally, the bioresin is functionalized with antibacterial silver oxide and bone-growth-promoting hydroxyapatite at various weight ratios to extend its application further. The results demonstrate the agile printability of the novel bioresin and its potential for transformative impact in biomedical applications, offering a versatile material platform for additive manufacturing-enabled personalized medicine. This work highlights the adaptability of the novel printable bioresin for real-life applications and its capacity for multiscale structural tailoring, potentially achieving properties comparable to native tissues and extending beyond conventional additive manufacturing techniques.The authors acknowledge the support of the National Science Foundation under Grant No. 2035663. The authors are also grateful for internal funding from San Diego State University. Funding from the United States Department of Defense (W911NF1410039, W911NF1810477, W911NF2310150, and N00174-23-1-0009) is also acknowledged. Additionally, this work was supported by the MCIN/AEI/10.13039/501100011033 and "European Union NextGenerationEU/PRTR" under grant PDC2021-121368-C21; the MCIN/AEI/10.13039/501100011033 under grants PID2020-112628RA-I00 and PID2020-118480RB-C22; and by the Generalitat Valenciana under grant CIAPOS/2021/271.John Wiley & SonsDepartamento de Ingeniería Mecánica y de MaterialesInstituto Universitario de Investigación Concertado de Ingeniería Mecánica y BiomecánicaEscuela Técnica Superior de Ingeniería IndustrialGeneralitat ValencianaU.S. Department of DefenseAgencia Estatal de InvestigaciónNational Science Foundation, EEUURepositorio Institucional de la Universitat Politècnica de València Riunet20252025-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://riunet.upv.es/handle/10251/214140reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PDC2021-121368-C21 IN PROCESS OPTIMIZATION OF TOOL LIFE IN INDUSTRIAL DRILLING OF HYBRID STACKS CFRP%2FMETALAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2020-112628RA-I00 DISEÑO INTEGRAL Y FABRICACION ADITIVA DE IMPLANTES POLIMERICOS PATIENT-SPECIFICAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2020-118480RB-C22 ANALISIS DE DEFECTOS EN LAMINADOS REFORZADOS CON FIBRAS DEBIDOS A PROCESOS DE FABRICACION Y EFECTO EN EL COMPORTAMIENTO A FATIGANational Science Foundation, China https://doi.org/10.13039/100000001 2035663Generalitat Valenciana https://doi.org/10.13039/501100003359 CIAPOS%2F2021%2F271U.S. Department of Defense https://doi.org/10.13039/100000005 W911NF1410039U.S. Department of Defense https://doi.org/10.13039/100000005 W911NF1810477U.S. Department of Defense https://doi.org/10.13039/100000005 W911NF2310150U.S. Department of Defense https://doi.org/10.13039/100000005 N00174-23-1-0009open accesshttp://purl.org/coar/access_right/c_abf2Reserva de todos los derechoshttp://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/2141402026-06-13T07:49:27Z
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