Gut microbiome-modulating properties of a polyphenol-enriched dietary supplement comprised of hibiscus and lemon verbena extracts. Monitoring of phenolic metabolites
This paper investigates the impact of a polyphenol-enriched supplement comprised of hibiscus (Hibiscus sabdariffa) and lemon verbena (Lippia Citriodora) (brand name Metabolaid®) on gut microbiota composition and functionality, by performing fermentations with human faecal microbiota under gut-simula...
| Autores: | , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/101061 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/101061 |
| Access Level: | acceso abierto |
| Palabra clave: | Non-communicable diseases Obesity Hibiscus Lemon verbena Polyphenols Phenylpropanoids Anthocyanins Faecal fermentation Gut microbiota Phenolic metabolites Microbiología (Veterinaria) Microbiología médica Ciencias Biomédicas 3309.90 Microbiología de Alimentos |
| Sumario: | This paper investigates the impact of a polyphenol-enriched supplement comprised of hibiscus (Hibiscus sabdariffa) and lemon verbena (Lippia Citriodora) (brand name Metabolaid®) on gut microbiota composition and functionality, by performing fermentations with human faecal microbiota under gut-simulated conditions. Results indicated that Metabolaid®, in a dose-dependent manner, modulated the gut bacteriome to higher relative abundances of some major genera (>3% of relative abundance) such as Bifidobacterium, Blautia and Faecalibacterium and of other minor genera such as Prevotella and Akkermansia. Metabolaid® also promoted increases in short-chain fatty acids (SCFAs) production, particularly butyric acid. On the other hand, it was confirmed that the compounds present in the Metabolaid® supplement (anthocyanins, verbascoside and hibiscus acid) were rapidly metabolized by the gut microbiota. Overall, these results reveal a certain level of gut microbiota-modulating properties of Metabolaid® that could be implicated, at least partially, in the mechanisms behind the potential beneficial effects of this supplement in obesity. |
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