Lipid Adaptations against Oxidative Challenge in the Healthy Adult Human Brain

It is assumed that the human brain is especially susceptible to oxidative stress, based on specific traits such as a higher rate of mitochondrial free radical production, a high content in peroxidizable fatty acids, and a low antioxidant defense. However, it is also evident that human neurons, altho...

Descripción completa

Detalles Bibliográficos
Autores: Jové, Mariona, Mota Martorell, Natàlia, Obis, Èlia, Sol, Joaquim, Martín Garí, Meritxell, Ferrer, Isidro (Ferrer Abizanda), Portero-Otin, Manuel, Pamplona, Reinald
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/193947
Acceso en línea:https://hdl.handle.net/2445/193947
Access Level:acceso abierto
Palabra clave:Colesterol
Cervell
Estrès oxidatiu
Lípids
Cholesterol
Brain
Oxidative stress
Lipids
id ES_0648cacb0ae3afdeff8eec9b4e51a7fa
oai_identifier_str oai:recercat.cat:2445/193947
network_acronym_str ES
network_name_str España
repository_id_str
spelling Lipid Adaptations against Oxidative Challenge in the Healthy Adult Human BrainJové, MarionaMota Martorell, NatàliaObis, ÈliaSol, JoaquimMartín Garí, MeritxellFerrer, Isidro (Ferrer Abizanda)Portero-Otin, ManuelPamplona, ReinaldColesterolCervellEstrès oxidatiuLípidsCholesterolBrainOxidative stressLipidsIt is assumed that the human brain is especially susceptible to oxidative stress, based on specific traits such as a higher rate of mitochondrial free radical production, a high content in peroxidizable fatty acids, and a low antioxidant defense. However, it is also evident that human neurons, although they are post-mitotic cells, survive throughout an entire lifetime. Therefore, to reduce or avoid the impact of oxidative stress on neuron functionality and survival, they must have evolved several adaptive mechanisms to cope with the deleterious effects of oxidative stress. Several of these antioxidant features are derived from lipid adaptations. At least six lipid adaptations against oxidative challenge in the healthy human brain can be discerned. In this work, we explore the idea that neurons and, by extension, the human brain is endowed with an important arsenal of non-pro-oxidant and antioxidant measures to preserve neuronal function, refuting part of the initial premise.MDPI AG2023202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion15 p.application/pdfhttps://hdl.handle.net/2445/193947Articles publicats en revistes (Patologia i Terapèutica Experimental)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/antiox12010177Antioxidants, 2023, vol. 12, num. 1, p. 177https://doi.org/10.3390/antiox12010177cc by (c) Jové, Mariona et al., 2023http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1939472026-05-29T05:05:01Z
dc.title.none.fl_str_mv Lipid Adaptations against Oxidative Challenge in the Healthy Adult Human Brain
title Lipid Adaptations against Oxidative Challenge in the Healthy Adult Human Brain
spellingShingle Lipid Adaptations against Oxidative Challenge in the Healthy Adult Human Brain
Jové, Mariona
Colesterol
Cervell
Estrès oxidatiu
Lípids
Cholesterol
Brain
Oxidative stress
Lipids
title_short Lipid Adaptations against Oxidative Challenge in the Healthy Adult Human Brain
title_full Lipid Adaptations against Oxidative Challenge in the Healthy Adult Human Brain
title_fullStr Lipid Adaptations against Oxidative Challenge in the Healthy Adult Human Brain
title_full_unstemmed Lipid Adaptations against Oxidative Challenge in the Healthy Adult Human Brain
title_sort Lipid Adaptations against Oxidative Challenge in the Healthy Adult Human Brain
dc.creator.none.fl_str_mv Jové, Mariona
Mota Martorell, Natàlia
Obis, Èlia
Sol, Joaquim
Martín Garí, Meritxell
Ferrer, Isidro (Ferrer Abizanda)
Portero-Otin, Manuel
Pamplona, Reinald
author Jové, Mariona
author_facet Jové, Mariona
Mota Martorell, Natàlia
Obis, Èlia
Sol, Joaquim
Martín Garí, Meritxell
Ferrer, Isidro (Ferrer Abizanda)
Portero-Otin, Manuel
Pamplona, Reinald
author_role author
author2 Mota Martorell, Natàlia
Obis, Èlia
Sol, Joaquim
Martín Garí, Meritxell
Ferrer, Isidro (Ferrer Abizanda)
Portero-Otin, Manuel
Pamplona, Reinald
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Colesterol
Cervell
Estrès oxidatiu
Lípids
Cholesterol
Brain
Oxidative stress
Lipids
topic Colesterol
Cervell
Estrès oxidatiu
Lípids
Cholesterol
Brain
Oxidative stress
Lipids
description It is assumed that the human brain is especially susceptible to oxidative stress, based on specific traits such as a higher rate of mitochondrial free radical production, a high content in peroxidizable fatty acids, and a low antioxidant defense. However, it is also evident that human neurons, although they are post-mitotic cells, survive throughout an entire lifetime. Therefore, to reduce or avoid the impact of oxidative stress on neuron functionality and survival, they must have evolved several adaptive mechanisms to cope with the deleterious effects of oxidative stress. Several of these antioxidant features are derived from lipid adaptations. At least six lipid adaptations against oxidative challenge in the healthy human brain can be discerned. In this work, we explore the idea that neurons and, by extension, the human brain is endowed with an important arsenal of non-pro-oxidant and antioxidant measures to preserve neuronal function, refuting part of the initial premise.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/193947
url https://hdl.handle.net/2445/193947
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/antiox12010177
Antioxidants, 2023, vol. 12, num. 1, p. 177
https://doi.org/10.3390/antiox12010177
dc.rights.none.fl_str_mv cc by (c) Jové, Mariona et al., 2023
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Jové, Mariona et al., 2023
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv Articles publicats en revistes (Patologia i Terapèutica Experimental)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869402908386131968
score 15,811543

Similares en LA Referencia