Early Management of OnabotulinumtoxinA Treatment in Chronic Migraine
OnabotulinumtoxinA (BT-A) quarterly was the first treatment approved specifically for chronic migraine (CM). It is unclear whether three cycles are better than two to assess early BT-A response. We performed a retrospective analysis on real-life prospectively collected data in 16 European headache c...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:240760 |
| Acceso en línea: | https://ddd.uab.cat/record/240760 https://dx.doi.org/urn:doi:10.1007/s40122-021-00253-0 |
| Access Level: | acceso abierto |
| Palabra clave: | Chronic migraine Multicenter study OnabotulinumtoxinA Real-life evidence |
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Early Management of OnabotulinumtoxinA Treatment in Chronic MigraineInsights from a Real-Life European Multicenter StudyOrnello, Raffaele|||0000-0001-9501-4031Ahmed, Fayyaz|||0000-0002-2746-0889Negro, Andrea|||0000-0003-3590-298XMiscio, Anna MariaSantoro, Antonio|||0000-0002-0798-6816Alpuente, Alicia|||0000-0001-5296-9401Russo, AntonioSilvestro, MarcelloCevoli, Sabina|||0000-0003-4668-4295Brunelli, Nicoletta|||0000-0002-8590-9015Vernieri, Fabrizio|||0000-0002-9594-9336Grazzi, LiciaBaraldi, Carlo|||0000-0001-8432-1888Guerzoni, Simona|||0000-0001-9589-2782Andreou, Anna P.|||0000-0002-7008-6626Lambru, GiorgioFrattale, Ilaria|||0000-0001-8733-1299Kamm, KatharinaRuscheweyh, Ruth|||0000-0001-9510-7158Russo, Marco|||0000-0001-5171-8555Torelli, Paola|||0000-0002-4072-2353Filatova, ElenaLatysheva, Nina|||0000-0001-9600-5540Gryglas-Dworak, AnnaStraburzynski, MarcinButera, Calogera|||0000-0003-2911-5525Colombo, BrunoFilippi, Massimo|||0000-0002-5485-0479Pozo-Rosich, Patricia|||0000-0003-0796-4702Martelletti, Paolo|||0000-0002-6556-4128Sacco, Simona|||0000-0003-0651-1939Chronic migraineMulticenter studyOnabotulinumtoxinAReal-life evidenceOnabotulinumtoxinA (BT-A) quarterly was the first treatment approved specifically for chronic migraine (CM). It is unclear whether three cycles are better than two to assess early BT-A response. We performed a retrospective analysis on real-life prospectively collected data in 16 European headache centers. All the centers provided data on patients treated with BT-A for CM over the first three cycles of treatment. For each treatment cycle we defined patients as "good responders" if reporting a ≥ 50% reduction in monthly headache days compared with the three months before starting BT-A, "partial responders" if reporting a 30-49% reduction in monthly headache days, and "non-responders" if reporting a < 30% reduction in monthly headache days or stopping the treatment before the third cycle. We included 2879 patients. Seven hundred and eighty-four (64.6%) of the 1213 patients reporting a good response during the first and/or the second cycle had a good response during the third cycle; 309 (49.3%) of the 627 patients reporting a partial response (but no good response) during the first and/or the second cycle had a good response during the third cycle; only 65 (6.3%) of the 1039 patients who did not respond during both the first two cycles achieved a good response during the third cycle. Multivariate analyses showed that partial or good response during the first or the second cycle were independently associated with good response during the third cycle. Our data suggest that patients with CM responding to BT-A during the first two cycles will likely benefit from the third cycle of treatment, while the probability that non-responders to the first two cycles start responding during the third cycle is low. These results can help guide the individual decision to stop or continue treatment after the second cycle in patients who have not responded to the first two cycles. The online version contains supplementary material available at 10.1007/s40122-021-00253-0.Universitat Autònoma de Barcelona 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/240760https://dx.doi.org/urn:doi:10.1007/s40122-021-00253-0reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2407602026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Early Management of OnabotulinumtoxinA Treatment in Chronic Migraine Insights from a Real-Life European Multicenter Study |
| title |
Early Management of OnabotulinumtoxinA Treatment in Chronic Migraine |
| spellingShingle |
Early Management of OnabotulinumtoxinA Treatment in Chronic Migraine Ornello, Raffaele|||0000-0001-9501-4031 Chronic migraine Multicenter study OnabotulinumtoxinA Real-life evidence |
| title_short |
Early Management of OnabotulinumtoxinA Treatment in Chronic Migraine |
| title_full |
Early Management of OnabotulinumtoxinA Treatment in Chronic Migraine |
| title_fullStr |
Early Management of OnabotulinumtoxinA Treatment in Chronic Migraine |
| title_full_unstemmed |
Early Management of OnabotulinumtoxinA Treatment in Chronic Migraine |
| title_sort |
Early Management of OnabotulinumtoxinA Treatment in Chronic Migraine |
| dc.creator.none.fl_str_mv |
Ornello, Raffaele|||0000-0001-9501-4031 Ahmed, Fayyaz|||0000-0002-2746-0889 Negro, Andrea|||0000-0003-3590-298X Miscio, Anna Maria Santoro, Antonio|||0000-0002-0798-6816 Alpuente, Alicia|||0000-0001-5296-9401 Russo, Antonio Silvestro, Marcello Cevoli, Sabina|||0000-0003-4668-4295 Brunelli, Nicoletta|||0000-0002-8590-9015 Vernieri, Fabrizio|||0000-0002-9594-9336 Grazzi, Licia Baraldi, Carlo|||0000-0001-8432-1888 Guerzoni, Simona|||0000-0001-9589-2782 Andreou, Anna P.|||0000-0002-7008-6626 Lambru, Giorgio Frattale, Ilaria|||0000-0001-8733-1299 Kamm, Katharina Ruscheweyh, Ruth|||0000-0001-9510-7158 Russo, Marco|||0000-0001-5171-8555 Torelli, Paola|||0000-0002-4072-2353 Filatova, Elena Latysheva, Nina|||0000-0001-9600-5540 Gryglas-Dworak, Anna Straburzynski, Marcin Butera, Calogera|||0000-0003-2911-5525 Colombo, Bruno Filippi, Massimo|||0000-0002-5485-0479 Pozo-Rosich, Patricia|||0000-0003-0796-4702 Martelletti, Paolo|||0000-0002-6556-4128 Sacco, Simona|||0000-0003-0651-1939 |
| author |
Ornello, Raffaele|||0000-0001-9501-4031 |
| author_facet |
Ornello, Raffaele|||0000-0001-9501-4031 Ahmed, Fayyaz|||0000-0002-2746-0889 Negro, Andrea|||0000-0003-3590-298X Miscio, Anna Maria Santoro, Antonio|||0000-0002-0798-6816 Alpuente, Alicia|||0000-0001-5296-9401 Russo, Antonio Silvestro, Marcello Cevoli, Sabina|||0000-0003-4668-4295 Brunelli, Nicoletta|||0000-0002-8590-9015 Vernieri, Fabrizio|||0000-0002-9594-9336 Grazzi, Licia Baraldi, Carlo|||0000-0001-8432-1888 Guerzoni, Simona|||0000-0001-9589-2782 Andreou, Anna P.|||0000-0002-7008-6626 Lambru, Giorgio Frattale, Ilaria|||0000-0001-8733-1299 Kamm, Katharina Ruscheweyh, Ruth|||0000-0001-9510-7158 Russo, Marco|||0000-0001-5171-8555 Torelli, Paola|||0000-0002-4072-2353 Filatova, Elena Latysheva, Nina|||0000-0001-9600-5540 Gryglas-Dworak, Anna Straburzynski, Marcin Butera, Calogera|||0000-0003-2911-5525 Colombo, Bruno Filippi, Massimo|||0000-0002-5485-0479 Pozo-Rosich, Patricia|||0000-0003-0796-4702 Martelletti, Paolo|||0000-0002-6556-4128 Sacco, Simona|||0000-0003-0651-1939 |
| author_role |
author |
| author2 |
Ahmed, Fayyaz|||0000-0002-2746-0889 Negro, Andrea|||0000-0003-3590-298X Miscio, Anna Maria Santoro, Antonio|||0000-0002-0798-6816 Alpuente, Alicia|||0000-0001-5296-9401 Russo, Antonio Silvestro, Marcello Cevoli, Sabina|||0000-0003-4668-4295 Brunelli, Nicoletta|||0000-0002-8590-9015 Vernieri, Fabrizio|||0000-0002-9594-9336 Grazzi, Licia Baraldi, Carlo|||0000-0001-8432-1888 Guerzoni, Simona|||0000-0001-9589-2782 Andreou, Anna P.|||0000-0002-7008-6626 Lambru, Giorgio Frattale, Ilaria|||0000-0001-8733-1299 Kamm, Katharina Ruscheweyh, Ruth|||0000-0001-9510-7158 Russo, Marco|||0000-0001-5171-8555 Torelli, Paola|||0000-0002-4072-2353 Filatova, Elena Latysheva, Nina|||0000-0001-9600-5540 Gryglas-Dworak, Anna Straburzynski, Marcin Butera, Calogera|||0000-0003-2911-5525 Colombo, Bruno Filippi, Massimo|||0000-0002-5485-0479 Pozo-Rosich, Patricia|||0000-0003-0796-4702 Martelletti, Paolo|||0000-0002-6556-4128 Sacco, Simona|||0000-0003-0651-1939 |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Chronic migraine Multicenter study OnabotulinumtoxinA Real-life evidence |
| topic |
Chronic migraine Multicenter study OnabotulinumtoxinA Real-life evidence |
| description |
OnabotulinumtoxinA (BT-A) quarterly was the first treatment approved specifically for chronic migraine (CM). It is unclear whether three cycles are better than two to assess early BT-A response. We performed a retrospective analysis on real-life prospectively collected data in 16 European headache centers. All the centers provided data on patients treated with BT-A for CM over the first three cycles of treatment. For each treatment cycle we defined patients as "good responders" if reporting a ≥ 50% reduction in monthly headache days compared with the three months before starting BT-A, "partial responders" if reporting a 30-49% reduction in monthly headache days, and "non-responders" if reporting a < 30% reduction in monthly headache days or stopping the treatment before the third cycle. We included 2879 patients. Seven hundred and eighty-four (64.6%) of the 1213 patients reporting a good response during the first and/or the second cycle had a good response during the third cycle; 309 (49.3%) of the 627 patients reporting a partial response (but no good response) during the first and/or the second cycle had a good response during the third cycle; only 65 (6.3%) of the 1039 patients who did not respond during both the first two cycles achieved a good response during the third cycle. Multivariate analyses showed that partial or good response during the first or the second cycle were independently associated with good response during the third cycle. Our data suggest that patients with CM responding to BT-A during the first two cycles will likely benefit from the third cycle of treatment, while the probability that non-responders to the first two cycles start responding during the third cycle is low. These results can help guide the individual decision to stop or continue treatment after the second cycle in patients who have not responded to the first two cycles. The online version contains supplementary material available at 10.1007/s40122-021-00253-0. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2 2021-01-01 2021 2021-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/240760 https://dx.doi.org/urn:doi:10.1007/s40122-021-00253-0 |
| url |
https://ddd.uab.cat/record/240760 https://dx.doi.org/urn:doi:10.1007/s40122-021-00253-0 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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Dipòsit Digital de Documents de la UAB |
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