Genotoxic effects in swimmers exposed to disinfection by-products in indoor swimming pools

37 páginas, 1 figura, 4 tablas.-- PDF con material suplementario.

Detalhes bibliográficos
Autores: Kogevinas, Manolis, Villanueva, Cristina M., Font-Ribera, Laia, Liviac, Danae, Bustamante, Mariona, Espinoza, Felicidad, Nieuwenhuijsen, Mark J., Espinosa, Aina, Fernández Ramón, M. Pilar, DeMarini, David M., Grimalt, Joan O., Grummt, Tamara, Marcos, Ricard
Tipo de documento: artigo
Data de publicação:2010
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/27624
Acesso em linha:http://hdl.handle.net/10261/27624
Access Level:Acceso aberto
Palavra-chave:Swimming pools
Water
Chlorination
Disinfection by-products
Cancer
Genotoxicity
Mutagenicity
Genetics
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spelling Genotoxic effects in swimmers exposed to disinfection by-products in indoor swimming poolsKogevinas, ManolisVillanueva, Cristina M.Font-Ribera, LaiaLiviac, DanaeBustamante, MarionaEspinoza, FelicidadNieuwenhuijsen, Mark J.Espinosa, AinaFernández Ramón, M. PilarDeMarini, David M.Grimalt, Joan O.Grummt, TamaraMarcos, RicardSwimming poolsWaterChlorinationDisinfection by-productsCancerGenotoxicityMutagenicityGenetics37 páginas, 1 figura, 4 tablas.-- PDF con material suplementario.[BACKGROUND]: Exposure to disinfection by-products (DBPs) in drinking water has been associated with cancer risk. A recent study found an increased bladder cancer risk among subjects attending swimming pools relative to those not attending.[OBJECTIVES]: To evaluate whether swimming in pools is associated with biomarkers of genotoxicity.[METHODS]: We collected blood, urine, and exhaled air samples from 49 non-smoking adult volunteers before and after they swam for 40 min in an indoor chlorinated pool. We estimated associations between the concentrations of four trihalomethanes in exhaled breath and changes in the following biomarkers: micronuclei and DNA damage (comet assay) in peripheral blood lymphocytes before and 1 h after swimming, urine mutagenicity (Ames assay) before and 2 h after swimming, and micronuclei in exfoliated urothelial cells before and 2 weeks after swimming. We also estimated associations and interactions with polymorphisms in genes related to DNA repair or DBP metabolism.[RESULTS]: After swimming, the total concentration of the four trihalomethanes in exhaled breath was seven times higher than before swimming. The change in the frequency of micronucleated lymphocytes after swimming increased in association with exhaled concentrations of the brominated trihalomethanes (p = 0.03 for CHCl2Br, p = 0.05 for CHClBr2, p = 0.01 for CHBr3) but not chloroform. Swimming was not associated with DNA damage detectable by the comet assay. Urine mutagenicity increased significantly after swimming in association with the concentration of exhaled CHBr3 (p = 0.004). No significant associations with changes in micronucleated urothelial cells were observed.[CONCLUSIONS]: Our findings support potential genotoxic effects of exposure to DBPs from swimming pools. The positive health effects gained by swimming could be increased by reducing the potential health risks of pool water.Research supported by Plan Nacional Grant SAF2005-07643-C03-01/02/03, Spain and FIS CP06/00341, Spain. CM Villanueva supported by the ISCIII (CP06/00341), Spain, L Font-Ribera by a predoctoral fellowship (FI06/00651), Spain, and D Liviac by a postgraduate fellowship UAB (PIF409-009), Barcelona.Peer reviewedNational Institute of Environmental Health Sciences (U.S.)National Institutes of Health (U.S.). PubMed CentralDepartment of Health and Human Services (U.S.)201020102010info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501296204 bytesapplication/pdfhttp://hdl.handle.net/10261/27624reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1289/ehp.1001959info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/276242026-05-22T06:33:51Z
dc.title.none.fl_str_mv Genotoxic effects in swimmers exposed to disinfection by-products in indoor swimming pools
title Genotoxic effects in swimmers exposed to disinfection by-products in indoor swimming pools
spellingShingle Genotoxic effects in swimmers exposed to disinfection by-products in indoor swimming pools
Kogevinas, Manolis
Swimming pools
Water
Chlorination
Disinfection by-products
Cancer
Genotoxicity
Mutagenicity
Genetics
title_short Genotoxic effects in swimmers exposed to disinfection by-products in indoor swimming pools
title_full Genotoxic effects in swimmers exposed to disinfection by-products in indoor swimming pools
title_fullStr Genotoxic effects in swimmers exposed to disinfection by-products in indoor swimming pools
title_full_unstemmed Genotoxic effects in swimmers exposed to disinfection by-products in indoor swimming pools
title_sort Genotoxic effects in swimmers exposed to disinfection by-products in indoor swimming pools
dc.creator.none.fl_str_mv Kogevinas, Manolis
Villanueva, Cristina M.
Font-Ribera, Laia
Liviac, Danae
Bustamante, Mariona
Espinoza, Felicidad
Nieuwenhuijsen, Mark J.
Espinosa, Aina
Fernández Ramón, M. Pilar
DeMarini, David M.
Grimalt, Joan O.
Grummt, Tamara
Marcos, Ricard
author Kogevinas, Manolis
author_facet Kogevinas, Manolis
Villanueva, Cristina M.
Font-Ribera, Laia
Liviac, Danae
Bustamante, Mariona
Espinoza, Felicidad
Nieuwenhuijsen, Mark J.
Espinosa, Aina
Fernández Ramón, M. Pilar
DeMarini, David M.
Grimalt, Joan O.
Grummt, Tamara
Marcos, Ricard
author_role author
author2 Villanueva, Cristina M.
Font-Ribera, Laia
Liviac, Danae
Bustamante, Mariona
Espinoza, Felicidad
Nieuwenhuijsen, Mark J.
Espinosa, Aina
Fernández Ramón, M. Pilar
DeMarini, David M.
Grimalt, Joan O.
Grummt, Tamara
Marcos, Ricard
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Swimming pools
Water
Chlorination
Disinfection by-products
Cancer
Genotoxicity
Mutagenicity
Genetics
topic Swimming pools
Water
Chlorination
Disinfection by-products
Cancer
Genotoxicity
Mutagenicity
Genetics
description 37 páginas, 1 figura, 4 tablas.-- PDF con material suplementario.
publishDate 2010
dc.date.none.fl_str_mv 2010
2010
2010
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/27624
url http://hdl.handle.net/10261/27624
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1289/ehp.1001959
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 296204 bytes
application/pdf
dc.publisher.none.fl_str_mv National Institute of Environmental Health Sciences (U.S.)
National Institutes of Health (U.S.). PubMed Central
Department of Health and Human Services (U.S.)
publisher.none.fl_str_mv National Institute of Environmental Health Sciences (U.S.)
National Institutes of Health (U.S.). PubMed Central
Department of Health and Human Services (U.S.)
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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repository.mail.fl_str_mv
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