Association between Food Intake, Clinical and Metabolic Markers and DNA Damage in Older Subjects

Abstract The use of DNA damage as marker of oxidative stress, metabolic dysfunction and age-related diseases is debated. The present study aimed at assessing the level of DNA damage (evaluated as DNA strand-breaks, endogenous and oxidatively-induced DNA damage) in a group of older subjects with inte...

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Autores: Del Bo, Cristian, Martini, Daniela, Bernardi, Stefano, Gigliotti, Letizia, Marino, Mirko, Gargari, Giorgio, Meroño, Tomás, Hidalgo Liberona, Nicole, Andrés Lacueva, Ma. Cristina, Kroon, Paul A., Cherubini, Antonio, Guglielmetti, Simone, Porrini, Marisa, Riso, Patrizia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/184402
Acceso en línea:https://hdl.handle.net/2445/184402
Access Level:acceso abierto
Palabra clave:Polifenols
Persones grans
Envelliment
Polyphenols
Older people
Aging
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spelling Association between Food Intake, Clinical and Metabolic Markers and DNA Damage in Older SubjectsDel Bo, CristianMartini, DanielaBernardi, StefanoGigliotti, LetiziaMarino, MirkoGargari, GiorgioMeroño, TomásHidalgo Liberona, NicoleAndrés Lacueva, Ma. CristinaKroon, Paul A.Cherubini, AntonioGuglielmetti, SimonePorrini, MarisaRiso, PatriziaPolifenolsPersones gransEnvellimentPolyphenolsOlder peopleAgingAbstract The use of DNA damage as marker of oxidative stress, metabolic dysfunction and age-related diseases is debated. The present study aimed at assessing the level of DNA damage (evaluated as DNA strand-breaks, endogenous and oxidatively-induced DNA damage) in a group of older subjects with intestinal permeability enrolled within the MaPLE (Gut and Blood Microbiomics for Studying the Effect of a Polyphenol-Rich Dietary Pattern on Intestinal Permeability in the Elderly) intervention trial, to evaluate its association with clinical, metabolic and dietary markers. DNA damage in peripheral blood mononuclear cells was assessed by the comet assay in 49 older subjects participating in the study. Clinical and metabolic markers, markers of inflammation, vascular function and intestinal permeability were determined in serum. Food intake was estimated by weighted food diaries. On the whole, a trend towards higher levels of DNA damage was observed in men compared to women (p = 0.071). A positive association between DNA damage and clinical/metabolic markers (e.g., uric acid, lipid profile) and an inverse association with dietary markers (e.g., vitamin C, E, B6, folates) were found and differed based on sex. By considering the importance of DNA stability during aging, the results obtained on sex differences and the potential role of dietary and metabolic factors on DNA damage underline the need for further investigations in a larger group of older adults to confirm the associations found and to promote preventive strategies.MDPI2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/184402Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/antiox10050730Antioxidants, 2021https://doi.org/10.3390/antiox10050730cc-by (c) Del Bo, Cristian et al., 2021https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1844022026-05-27T06:46:51Z
dc.title.none.fl_str_mv Association between Food Intake, Clinical and Metabolic Markers and DNA Damage in Older Subjects
title Association between Food Intake, Clinical and Metabolic Markers and DNA Damage in Older Subjects
spellingShingle Association between Food Intake, Clinical and Metabolic Markers and DNA Damage in Older Subjects
Del Bo, Cristian
Polifenols
Persones grans
Envelliment
Polyphenols
Older people
Aging
title_short Association between Food Intake, Clinical and Metabolic Markers and DNA Damage in Older Subjects
title_full Association between Food Intake, Clinical and Metabolic Markers and DNA Damage in Older Subjects
title_fullStr Association between Food Intake, Clinical and Metabolic Markers and DNA Damage in Older Subjects
title_full_unstemmed Association between Food Intake, Clinical and Metabolic Markers and DNA Damage in Older Subjects
title_sort Association between Food Intake, Clinical and Metabolic Markers and DNA Damage in Older Subjects
dc.creator.none.fl_str_mv Del Bo, Cristian
Martini, Daniela
Bernardi, Stefano
Gigliotti, Letizia
Marino, Mirko
Gargari, Giorgio
Meroño, Tomás
Hidalgo Liberona, Nicole
Andrés Lacueva, Ma. Cristina
Kroon, Paul A.
Cherubini, Antonio
Guglielmetti, Simone
Porrini, Marisa
Riso, Patrizia
author Del Bo, Cristian
author_facet Del Bo, Cristian
Martini, Daniela
Bernardi, Stefano
Gigliotti, Letizia
Marino, Mirko
Gargari, Giorgio
Meroño, Tomás
Hidalgo Liberona, Nicole
Andrés Lacueva, Ma. Cristina
Kroon, Paul A.
Cherubini, Antonio
Guglielmetti, Simone
Porrini, Marisa
Riso, Patrizia
author_role author
author2 Martini, Daniela
Bernardi, Stefano
Gigliotti, Letizia
Marino, Mirko
Gargari, Giorgio
Meroño, Tomás
Hidalgo Liberona, Nicole
Andrés Lacueva, Ma. Cristina
Kroon, Paul A.
Cherubini, Antonio
Guglielmetti, Simone
Porrini, Marisa
Riso, Patrizia
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Polifenols
Persones grans
Envelliment
Polyphenols
Older people
Aging
topic Polifenols
Persones grans
Envelliment
Polyphenols
Older people
Aging
description Abstract The use of DNA damage as marker of oxidative stress, metabolic dysfunction and age-related diseases is debated. The present study aimed at assessing the level of DNA damage (evaluated as DNA strand-breaks, endogenous and oxidatively-induced DNA damage) in a group of older subjects with intestinal permeability enrolled within the MaPLE (Gut and Blood Microbiomics for Studying the Effect of a Polyphenol-Rich Dietary Pattern on Intestinal Permeability in the Elderly) intervention trial, to evaluate its association with clinical, metabolic and dietary markers. DNA damage in peripheral blood mononuclear cells was assessed by the comet assay in 49 older subjects participating in the study. Clinical and metabolic markers, markers of inflammation, vascular function and intestinal permeability were determined in serum. Food intake was estimated by weighted food diaries. On the whole, a trend towards higher levels of DNA damage was observed in men compared to women (p = 0.071). A positive association between DNA damage and clinical/metabolic markers (e.g., uric acid, lipid profile) and an inverse association with dietary markers (e.g., vitamin C, E, B6, folates) were found and differed based on sex. By considering the importance of DNA stability during aging, the results obtained on sex differences and the potential role of dietary and metabolic factors on DNA damage underline the need for further investigations in a larger group of older adults to confirm the associations found and to promote preventive strategies.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/184402
url https://hdl.handle.net/2445/184402
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/antiox10050730
Antioxidants, 2021
https://doi.org/10.3390/antiox10050730
dc.rights.none.fl_str_mv cc-by (c) Del Bo, Cristian et al., 2021
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Del Bo, Cristian et al., 2021
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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