Catastrophic Streptococcus pyogenes Disease: A Personalized Approach Based on Phenotypes and Treatable Traits
Multiorgan dysfunction; Sepsis phenotypes; Streptococcal toxic shock syndrome
| Autores: | , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Departament de Salut de la Generalitat de Catalunya (DS) |
| Repositorio: | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| OAI Identifier: | oai:scientiasalut.gencat.cat:11351/11135 |
| Acceso en línea: | https://hdl.handle.net/11351/11135 |
| Access Level: | acceso abierto |
| Palabra clave: | Fenotip Xoc sèptic Estreptococs Malalties bacterianes DISEASES::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Positive Bacterial Infections::Streptococcal Infections DISEASES::Bacterial Infections and Mycoses::Infection::Sepsis::Shock, Septic PHENOMENA AND PROCESSES::Genetic Phenomena::Phenotype ENFERMEDADES::infecciones bacterianas y micosis::infecciones bacterianas::infecciones por bacterias grampositivas::infecciones estreptocócicas ENFERMEDADES::infecciones bacterianas y micosis::infección::sepsis::choque séptico FENÓMENOS Y PROCESOS::fenómenos genéticos::fenotipo |
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Catastrophic Streptococcus pyogenes Disease: A Personalized Approach Based on Phenotypes and Treatable Traits |
| title |
Catastrophic Streptococcus pyogenes Disease: A Personalized Approach Based on Phenotypes and Treatable Traits |
| spellingShingle |
Catastrophic Streptococcus pyogenes Disease: A Personalized Approach Based on Phenotypes and Treatable Traits Maldonado Toral, Carolina Fenotip Xoc sèptic Estreptococs Malalties bacterianes DISEASES::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Positive Bacterial Infections::Streptococcal Infections DISEASES::Bacterial Infections and Mycoses::Infection::Sepsis::Shock, Septic PHENOMENA AND PROCESSES::Genetic Phenomena::Phenotype ENFERMEDADES::infecciones bacterianas y micosis::infecciones bacterianas::infecciones por bacterias grampositivas::infecciones estreptocócicas ENFERMEDADES::infecciones bacterianas y micosis::infección::sepsis::choque séptico FENÓMENOS Y PROCESOS::fenómenos genéticos::fenotipo |
| title_short |
Catastrophic Streptococcus pyogenes Disease: A Personalized Approach Based on Phenotypes and Treatable Traits |
| title_full |
Catastrophic Streptococcus pyogenes Disease: A Personalized Approach Based on Phenotypes and Treatable Traits |
| title_fullStr |
Catastrophic Streptococcus pyogenes Disease: A Personalized Approach Based on Phenotypes and Treatable Traits |
| title_full_unstemmed |
Catastrophic Streptococcus pyogenes Disease: A Personalized Approach Based on Phenotypes and Treatable Traits |
| title_sort |
Catastrophic Streptococcus pyogenes Disease: A Personalized Approach Based on Phenotypes and Treatable Traits |
| dc.creator.none.fl_str_mv |
Maldonado Toral, Carolina Ruiz Sanmartin, Adolfo Martin Sánchez, Laura Bajaña Mindiolaza, Ivan Rene Bastidas Ospina, Juliana Lopez-Martinez, Rocio Riera del Brio, Jordi Ruiz-Rodriguez, Juan Carlos Chiscano Camon, Luis González-López, Juan José Ferrer, Ricard Franco-Jarava, Clara Larrosa, María Nieves Nuvials, Xavier |
| author |
Maldonado Toral, Carolina |
| author_facet |
Maldonado Toral, Carolina Ruiz Sanmartin, Adolfo Martin Sánchez, Laura Bajaña Mindiolaza, Ivan Rene Bastidas Ospina, Juliana Lopez-Martinez, Rocio Riera del Brio, Jordi Ruiz-Rodriguez, Juan Carlos Chiscano Camon, Luis González-López, Juan José Ferrer, Ricard Franco-Jarava, Clara Larrosa, María Nieves Nuvials, Xavier |
| author_role |
author |
| author2 |
Ruiz Sanmartin, Adolfo Martin Sánchez, Laura Bajaña Mindiolaza, Ivan Rene Bastidas Ospina, Juliana Lopez-Martinez, Rocio Riera del Brio, Jordi Ruiz-Rodriguez, Juan Carlos Chiscano Camon, Luis González-López, Juan José Ferrer, Ricard Franco-Jarava, Clara Larrosa, María Nieves Nuvials, Xavier |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [Ruiz-Rodríguez JC, Chiscano-Camón L, Ferrer R] Servei de Medicina Intensiva, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca de Shock, Disfunció Orgànica i Ressuscitació, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Maldonado C, Ruiz-Sanmartin A, Martin L, Bajaña I, Bastidas J, Riera J, Nuvials-Casals X] Servei de Medicina Intensiva, Vall d’Hebron Hospital Universitari, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca de Shock, Disfunció Orgànica i Ressuscitació, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Lopez-Martinez R, Franco-Jarava C] Servei d’Immunologia, Vall d’Hebron Hospital Universitari, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [González-López JJ, Larrosa N] Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Fenotip Xoc sèptic Estreptococs Malalties bacterianes DISEASES::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Positive Bacterial Infections::Streptococcal Infections DISEASES::Bacterial Infections and Mycoses::Infection::Sepsis::Shock, Septic PHENOMENA AND PROCESSES::Genetic Phenomena::Phenotype ENFERMEDADES::infecciones bacterianas y micosis::infecciones bacterianas::infecciones por bacterias grampositivas::infecciones estreptocócicas ENFERMEDADES::infecciones bacterianas y micosis::infección::sepsis::choque séptico FENÓMENOS Y PROCESOS::fenómenos genéticos::fenotipo |
| topic |
Fenotip Xoc sèptic Estreptococs Malalties bacterianes DISEASES::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Positive Bacterial Infections::Streptococcal Infections DISEASES::Bacterial Infections and Mycoses::Infection::Sepsis::Shock, Septic PHENOMENA AND PROCESSES::Genetic Phenomena::Phenotype ENFERMEDADES::infecciones bacterianas y micosis::infecciones bacterianas::infecciones por bacterias grampositivas::infecciones estreptocócicas ENFERMEDADES::infecciones bacterianas y micosis::infección::sepsis::choque séptico FENÓMENOS Y PROCESOS::fenómenos genéticos::fenotipo |
| description |
Multiorgan dysfunction; Sepsis phenotypes; Streptococcal toxic shock syndrome |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2024 2024 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/11351/11135 |
| url |
https://hdl.handle.net/11351/11135 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Antibiotics;13(2) https://doi.org/10.3390/antibiotics13020187 |
| dc.rights.none.fl_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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Scientia reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut instname:Departament de Salut de la Generalitat de Catalunya (DS) |
| instname_str |
Departament de Salut de la Generalitat de Catalunya (DS) |
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Scientia. Dipòsit d'Informació Digital del Departament de Salut |
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Scientia. Dipòsit d'Informació Digital del Departament de Salut |
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1869402899646251008 |
| spelling |
Catastrophic Streptococcus pyogenes Disease: A Personalized Approach Based on Phenotypes and Treatable TraitsMaldonado Toral, CarolinaRuiz Sanmartin, AdolfoMartin Sánchez, LauraBajaña Mindiolaza, Ivan ReneBastidas Ospina, JulianaLopez-Martinez, RocioRiera del Brio, JordiRuiz-Rodriguez, Juan CarlosChiscano Camon, LuisGonzález-López, Juan JoséFerrer, RicardFranco-Jarava, ClaraLarrosa, María NievesNuvials, XavierFenotipXoc sèpticEstreptococsMalalties bacterianesDISEASES::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Positive Bacterial Infections::Streptococcal InfectionsDISEASES::Bacterial Infections and Mycoses::Infection::Sepsis::Shock, SepticPHENOMENA AND PROCESSES::Genetic Phenomena::PhenotypeENFERMEDADES::infecciones bacterianas y micosis::infecciones bacterianas::infecciones por bacterias grampositivas::infecciones estreptocócicasENFERMEDADES::infecciones bacterianas y micosis::infección::sepsis::choque sépticoFENÓMENOS Y PROCESOS::fenómenos genéticos::fenotipoMultiorgan dysfunction; Sepsis phenotypes; Streptococcal toxic shock syndromeDisfunción multiorgánica; Fenotipos de sepsis; Síndrome de shock tóxico estreptocócicoDisfunció multiorgànica; Fenotips de sepsi; Síndrome de shock tòxic estreptocòcicStreptococcal toxic shock syndrome (STTS) is a critical medical emergency marked by high morbidity and mortality, necessitating swift awareness, targeted treatment, and early source control due to its rapid symptom manifestation. This report focuses on a cohort of 13 patients admitted to Vall d'Hebron University Hospital Intensive Care Unit, Barcelona, from November 2022 to March 2023, exhibiting invasive Streptococcus pyogenes infections and meeting institutional sepsis code activation criteria. The primary infections were community-acquired pneumonia (61.5%) and skin/soft tissue infection (30.8%). All patients received prompt antibiotic treatment, with clinical source control through thoracic drainage (30.8%) or surgical means (23.1%). Organ support involved invasive mechanical ventilation, vasopressors, and continuous renal replacement therapy as per guidelines. Of note, 76.9% of patients experienced septic cardiomyopathy, and 53.8% required extracorporeal membrane oxygenation (ECMO). The study identified three distinct phenotypic profiles-hyperinflammatory, low perfusion, and hypogammaglobulinemic-which could guide personalized therapeutic approaches. STTS, with a mean SOFA score of 17 (5.7) and a 53.8% requiring ECMO, underscores the need for precision medicine-based rescue therapies and sepsis phenotype identification. Integrating these strategies with prompt antibiotics and efficient source control offers a potential avenue to mitigate organ failure, enhancing patient survival and recovery in the face of this severe clinical condition.MDPIInstitut Català de la Salut[Ruiz-Rodríguez JC, Chiscano-Camón L, Ferrer R] Servei de Medicina Intensiva, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca de Shock, Disfunció Orgànica i Ressuscitació, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Maldonado C, Ruiz-Sanmartin A, Martin L, Bajaña I, Bastidas J, Riera J, Nuvials-Casals X] Servei de Medicina Intensiva, Vall d’Hebron Hospital Universitari, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca de Shock, Disfunció Orgànica i Ressuscitació, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Lopez-Martinez R, Franco-Jarava C] Servei d’Immunologia, Vall d’Hebron Hospital Universitari, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [González-López JJ, Larrosa N] Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202420242024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/11135Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésAntibiotics;13(2)https://doi.org/10.3390/antibiotics13020187Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/111352026-06-12T09:38:37Z |
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15,81155 |