Functional brain connectivity prior to the COVID-19 outbreak moderates the effects of coping and perceived stress on mental health changes. A first year of COVID-19 pandemic follow-up study
The COVID-19 pandemic provides a unique opportunity to investigate the psychological impact of a global major adverse situation. Our aim was to study, in a longitudinal prospective, the demographic, psychological and neurobiological factors associated with inter-individual differences in resilience...
| Autores: | , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:282681 |
| Acceso en línea: | https://ddd.uab.cat/record/282681 https://dx.doi.org/urn:doi:10.1016/j.bpsc.2022.08.005 |
| Access Level: | acceso abierto |
| Palabra clave: | Mental health Coping strategies Perceived stress Brain networks COVID-19 pandemic |
| Sumario: | The COVID-19 pandemic provides a unique opportunity to investigate the psychological impact of a global major adverse situation. Our aim was to study, in a longitudinal prospective, the demographic, psychological and neurobiological factors associated with inter-individual differences in resilience to mental health pandemic impact. We included 2,023 healthy participants (age: 54.32±7.18 years, 65.69% females) from the Barcelona Brain Health Initiative cohort. A linear mixed model was used to characterize the change in anxiety and depression symptoms based on the collected pre- and during-COVID-19 data. During pandemic, psychological variables assessing individual differences in perceived stress and coping strategies were obtained. Additionally, in a subsample (N=433, age:53.02 ± 7.04 years, 46.88% females) with pre-pandemic resting-state functional magnetic resonance imaging available, networks' system segregation (SyS) was calculated. Multivariate linear models were fitted to test associations between COVID-19-related changes in mental health and demographics, psychological features and brain networks status. The whole sample showed a general increase in anxiety and depressive symptoms after the pandemic onset, and both age and sex were independent predictors. Coping strategies attenuated the impact of perceived stress on mental health. SyS of fronto-parietal control and default mode networks were found to modulate the impact of perceived stress on mental health. Preventive strategies destined for the promotion of mental health at an individual's level during future similar adverse events should consider intervening on sociodemographic and psychological factors, as well as their interplay with neurobiological substrates. |
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