Recent Advances in the Enantioselective Synthesis of Chiral Amines via Transition Metal-Catalyzed Asymmetric Hydrogenation
Chiral amines are key structural motifs present in a wide variety of natural products, drugs, and other biologically active compounds. During the last decade, significant advances have been made with respect to the enantioselective synthesis of chiral amines, many of them based on catalytic asymmetr...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/188749 |
| Acceso en línea: | https://hdl.handle.net/2445/188749 |
| Access Level: | acceso abierto |
| Palabra clave: | Catàlisi Hidrogenació Amines Catalysis Hydrogenation |
| Sumario: | Chiral amines are key structural motifs present in a wide variety of natural products, drugs, and other biologically active compounds. During the last decade, significant advances have been made with respect to the enantioselective synthesis of chiral amines, many of them based on catalytic asymmetric hydrogenation (AH). The present review covers the use of AH in the synthesis of chiral amines bearing a stereogenic center either in α, β or γ position with respect to the nitrogen atom, reported from 2010 to 2020. Therefore, we provide an overview of the recent advances in the AH of imines, enamides, enamines, allyl amines and N-heteroaromatic compounds. |
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