Targeting AgRP neurons to maintain energy balance: lessons from animal models

The current obesity epidemic is a major worldwide health and economic burden. In the modern environment, an increase in the intake of high-fat and high-sugar foods plays a crucial role in the development of obesity by disrupting the mechanisms governing food intake and energy balance. Food intake an...

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Autores: Zagmutt Caroxa, Sebastián, Mera Nanín, Paula, Soler Vázquez, M. Carmen, Herrero Rodríguez, Laura, Serra i Cucurull, Dolors
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2018
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/125980
Acceso en línea:https://hdl.handle.net/2445/125980
Access Level:acceso abierto
Palabra clave:Sistema nerviós central
Consum d'aliments
Neurofisiologia
Psicofisiologia
Obesitat
Central nervous system
Food consumption
Neurophysiology
Psychophysiology
Obesity
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spelling Targeting AgRP neurons to maintain energy balance: lessons from animal modelsZagmutt Caroxa, SebastiánMera Nanín, PaulaSoler Vázquez, M. CarmenHerrero Rodríguez, LauraSerra i Cucurull, DolorsSistema nerviós centralConsum d'alimentsNeurofisiologiaPsicofisiologiaObesitatCentral nervous systemFood consumptionNeurophysiologyPsychophysiologyObesityThe current obesity epidemic is a major worldwide health and economic burden. In the modern environment, an increase in the intake of high-fat and high-sugar foods plays a crucial role in the development of obesity by disrupting the mechanisms governing food intake and energy balance. Food intake and whole-body energy balance are regulated by the central nervous system through a sophisticated neuronal network located mostly in the hypothalamus. In particular, the hypothalamic arcuate nucleus (ARC) is a fundamental center that senses hormonal and nutrient-related signals informing about the energy state of the organism. The ARC contains two small, defined populations of neurons with opposite functions: anorexigenic proopiomelanocortin (POMC)-expressing neurons and orexigenic Agouti-related protein (AgRP)-expressing neurons. AgRP neurons, which also co-produce neuropeptide Y (NPY) and γ-Aminobutyric acid (GABA), are involved in an increase in hunger and a decrease in energy expenditure. In this review, we summarize the key findings from the most common animal models targeting AgRP neurons and the tools used to discern the role of this specific neuronal population in the control of peripheral metabolism, appetite, feeding-related behavior, and other complex behaviors. We also discuss how knowledge gained from these studies has revealed new pathways and key proteins that could be potential therapeutic targets to reduce appetite and food addictions in obesity and other diseases.Elsevier B.V.2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/125980Articles publicats en revistes (Bioquímica i Fisiologia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1016/j.bcp.2018.07.008Biochemical Pharmacology, 2018, vol. 155, p. 224-232https://doi.org/10.1016/j.bcp.2018.07.008cc-by-nc-nd (c) Elsevier B.V., 2018http://creativecommons.org/licenses/by-nc-nd/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1259802026-05-27T06:46:51Z
dc.title.none.fl_str_mv Targeting AgRP neurons to maintain energy balance: lessons from animal models
title Targeting AgRP neurons to maintain energy balance: lessons from animal models
spellingShingle Targeting AgRP neurons to maintain energy balance: lessons from animal models
Zagmutt Caroxa, Sebastián
Sistema nerviós central
Consum d'aliments
Neurofisiologia
Psicofisiologia
Obesitat
Central nervous system
Food consumption
Neurophysiology
Psychophysiology
Obesity
title_short Targeting AgRP neurons to maintain energy balance: lessons from animal models
title_full Targeting AgRP neurons to maintain energy balance: lessons from animal models
title_fullStr Targeting AgRP neurons to maintain energy balance: lessons from animal models
title_full_unstemmed Targeting AgRP neurons to maintain energy balance: lessons from animal models
title_sort Targeting AgRP neurons to maintain energy balance: lessons from animal models
dc.creator.none.fl_str_mv Zagmutt Caroxa, Sebastián
Mera Nanín, Paula
Soler Vázquez, M. Carmen
Herrero Rodríguez, Laura
Serra i Cucurull, Dolors
author Zagmutt Caroxa, Sebastián
author_facet Zagmutt Caroxa, Sebastián
Mera Nanín, Paula
Soler Vázquez, M. Carmen
Herrero Rodríguez, Laura
Serra i Cucurull, Dolors
author_role author
author2 Mera Nanín, Paula
Soler Vázquez, M. Carmen
Herrero Rodríguez, Laura
Serra i Cucurull, Dolors
author2_role author
author
author
author
dc.subject.none.fl_str_mv Sistema nerviós central
Consum d'aliments
Neurofisiologia
Psicofisiologia
Obesitat
Central nervous system
Food consumption
Neurophysiology
Psychophysiology
Obesity
topic Sistema nerviós central
Consum d'aliments
Neurofisiologia
Psicofisiologia
Obesitat
Central nervous system
Food consumption
Neurophysiology
Psychophysiology
Obesity
description The current obesity epidemic is a major worldwide health and economic burden. In the modern environment, an increase in the intake of high-fat and high-sugar foods plays a crucial role in the development of obesity by disrupting the mechanisms governing food intake and energy balance. Food intake and whole-body energy balance are regulated by the central nervous system through a sophisticated neuronal network located mostly in the hypothalamus. In particular, the hypothalamic arcuate nucleus (ARC) is a fundamental center that senses hormonal and nutrient-related signals informing about the energy state of the organism. The ARC contains two small, defined populations of neurons with opposite functions: anorexigenic proopiomelanocortin (POMC)-expressing neurons and orexigenic Agouti-related protein (AgRP)-expressing neurons. AgRP neurons, which also co-produce neuropeptide Y (NPY) and γ-Aminobutyric acid (GABA), are involved in an increase in hunger and a decrease in energy expenditure. In this review, we summarize the key findings from the most common animal models targeting AgRP neurons and the tools used to discern the role of this specific neuronal population in the control of peripheral metabolism, appetite, feeding-related behavior, and other complex behaviors. We also discuss how knowledge gained from these studies has revealed new pathways and key proteins that could be potential therapeutic targets to reduce appetite and food addictions in obesity and other diseases.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/125980
url https://hdl.handle.net/2445/125980
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.bcp.2018.07.008
Biochemical Pharmacology, 2018, vol. 155, p. 224-232
https://doi.org/10.1016/j.bcp.2018.07.008
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Elsevier B.V., 2018
http://creativecommons.org/licenses/by-nc-nd/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Elsevier B.V., 2018
http://creativecommons.org/licenses/by-nc-nd/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Fisiologia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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