A time series analysis of the relationship between apparent temperature, air pollutants and ischemic stroke in Madrid, Spain

The understanding of the role of environment on the pathogenesis of stroke is gaining importance in the context of climate change. This study analyzes the temporal pattern of ischemic stroke (IS) in Madrid, Spain, during a 13-year period (2001-2013), and the relationship between ischemic stroke (adm...

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Authors: Royé, Dominic, Zarrabeitia Cimiano, María Teresa, Riancho Zarrabeitia, Javier, Santurtún Zarrabeitia, Ana
Format: article
Publication Date:2019
Country:España
Institution:Universidad de Cantabria (UC)
Repository:UCrea Repositorio Abierto de la Universidad de Cantabria
Language:English
OAI Identifier:oai:repositorio.unican.es:10902/16376
Online Access:http://hdl.handle.net/10902/16376
Access Level:Open access
Keyword:Admissions
Air Pollutants
Apparent Temperature
Ischemic Stroke
Mortality
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spelling A time series analysis of the relationship between apparent temperature, air pollutants and ischemic stroke in Madrid, SpainRoyé, DominicZarrabeitia Cimiano, María TeresaRiancho Zarrabeitia, JavierSanturtún Zarrabeitia, AnaAdmissionsAir PollutantsApparent TemperatureIschemic StrokeMortalityThe understanding of the role of environment on the pathogenesis of stroke is gaining importance in the context of climate change. This study analyzes the temporal pattern of ischemic stroke (IS) in Madrid, Spain, during a 13-year period (2001-2013), and the relationship between ischemic stroke (admissions and deaths) incidence and environmental factors on a daily scale by using a quasi-Poisson regression model. To assess potential delayed and non-linear effects of air pollutants and Apparent Temperature (AT), a biometeorological index which represents human thermal comfort on IS, a lag non-linear model was fitted in a generalized additive model. The mortality rate followed a downward trend over the studied period, however admission rates progressively increased. Our results show that both increases and decreases in AT had a marked relationship with IS deaths, while hospital admissions were only associated with low AT. When analyzing the cumulative effects (for lag 0-14 days), with an AT of 1.7?°C (percentile 5%) a RR of 1.20 (95% CI, 1.05-1.37) for IS mortality and a RR of 1.09 (95% CI, 0.91-1.29) for morbidity is estimated. Concerning gender differences, men show higher risks of mortality in low temperatures and women in high temperatures. No significant relationship was found between air pollutant concentrations and IS morbi-mortality, but this result must be interpreted with caution, since there are strong spatial fluctuations of the former between nearby geographical areas that make it difficult to perform correlation analyses.ElsevierUniversidad de Cantabria20192019-06-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttp://hdl.handle.net/10902/16376Environ Res. 2019 Jun;173:349-358reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/163762026-06-02T12:39:31Z
dc.title.none.fl_str_mv A time series analysis of the relationship between apparent temperature, air pollutants and ischemic stroke in Madrid, Spain
title A time series analysis of the relationship between apparent temperature, air pollutants and ischemic stroke in Madrid, Spain
spellingShingle A time series analysis of the relationship between apparent temperature, air pollutants and ischemic stroke in Madrid, Spain
Royé, Dominic
Admissions
Air Pollutants
Apparent Temperature
Ischemic Stroke
Mortality
title_short A time series analysis of the relationship between apparent temperature, air pollutants and ischemic stroke in Madrid, Spain
title_full A time series analysis of the relationship between apparent temperature, air pollutants and ischemic stroke in Madrid, Spain
title_fullStr A time series analysis of the relationship between apparent temperature, air pollutants and ischemic stroke in Madrid, Spain
title_full_unstemmed A time series analysis of the relationship between apparent temperature, air pollutants and ischemic stroke in Madrid, Spain
title_sort A time series analysis of the relationship between apparent temperature, air pollutants and ischemic stroke in Madrid, Spain
dc.creator.none.fl_str_mv Royé, Dominic
Zarrabeitia Cimiano, María Teresa
Riancho Zarrabeitia, Javier
Santurtún Zarrabeitia, Ana
author Royé, Dominic
author_facet Royé, Dominic
Zarrabeitia Cimiano, María Teresa
Riancho Zarrabeitia, Javier
Santurtún Zarrabeitia, Ana
author_role author
author2 Zarrabeitia Cimiano, María Teresa
Riancho Zarrabeitia, Javier
Santurtún Zarrabeitia, Ana
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv Admissions
Air Pollutants
Apparent Temperature
Ischemic Stroke
Mortality
topic Admissions
Air Pollutants
Apparent Temperature
Ischemic Stroke
Mortality
description The understanding of the role of environment on the pathogenesis of stroke is gaining importance in the context of climate change. This study analyzes the temporal pattern of ischemic stroke (IS) in Madrid, Spain, during a 13-year period (2001-2013), and the relationship between ischemic stroke (admissions and deaths) incidence and environmental factors on a daily scale by using a quasi-Poisson regression model. To assess potential delayed and non-linear effects of air pollutants and Apparent Temperature (AT), a biometeorological index which represents human thermal comfort on IS, a lag non-linear model was fitted in a generalized additive model. The mortality rate followed a downward trend over the studied period, however admission rates progressively increased. Our results show that both increases and decreases in AT had a marked relationship with IS deaths, while hospital admissions were only associated with low AT. When analyzing the cumulative effects (for lag 0-14 days), with an AT of 1.7?°C (percentile 5%) a RR of 1.20 (95% CI, 1.05-1.37) for IS mortality and a RR of 1.09 (95% CI, 0.91-1.29) for morbidity is estimated. Concerning gender differences, men show higher risks of mortality in low temperatures and women in high temperatures. No significant relationship was found between air pollutant concentrations and IS morbi-mortality, but this result must be interpreted with caution, since there are strong spatial fluctuations of the former between nearby geographical areas that make it difficult to perform correlation analyses.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-06-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10902/16376
url http://hdl.handle.net/10902/16376
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Environ Res. 2019 Jun;173:349-358
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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