Role of Actin Cytoskeleton Reorganization in Polarized Secretory Traffic at the Immunological Synapse

© 2021 Calvo and Izquierdo.

Detalhes bibliográficos
Autores: Calvo, Victor, Izquierdo, Manuel
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2021
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/231340
Acesso em linha:http://hdl.handle.net/10261/231340
Access Level:Acceso aberto
Palavra-chave:T lymphocytes
B lymphocytes
Immune synapse
Actin cytoskeleton
Protein kinase C δ
Centrosomes
Multivesicular bodies
FMNL1
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spelling Role of Actin Cytoskeleton Reorganization in Polarized Secretory Traffic at the Immunological SynapseCalvo, VictorIzquierdo, ManuelT lymphocytesB lymphocytesImmune synapseActin cytoskeletonProtein kinase C δCentrosomesMultivesicular bodiesFMNL1© 2021 Calvo and Izquierdo.T cell receptor (TCR) and B cell receptor (BCR) stimulation by antigen presented on an antigen-presenting cell (APC) induces the formation of the immune synapse (IS), the convergence of secretory vesicles from T and B lymphocytes toward the centrosome, and the polarization of the centrosome to the immune synapse. Immune synapse formation is associated with an initial increase in cortical F-actin at the synapse, followed by a decrease in F-actin density at the central region of the immune synapse, which contains the secretory domain. These reversible, actin cytoskeleton reorganization processes occur during lytic granule degranulation in cytotoxic T lymphocytes (CTL) and cytokine-containing vesicle secretion in T-helper (Th) lymphocytes. Recent evidences obtained in T and B lymphocytes forming synapses show that F-actin reorganization also occurs at the centrosomal area. F-actin reduction at the centrosomal area appears to be involved in centrosome polarization. In this review we deal with the biological significance of both cortical and centrosomal area F-actin reorganization and some of the derived biological consequences.This research was funded by grants from the Spanish Ministerio de Economía y Competitividad (MINECO), Plan Nacional de Investigación Científica (SAF2016-77561-R and PID2020-114148RB-I00) to MI, which was in part granted with FEDER funding (EC), corresponding to the Programa Estatal de Investigación, Desarrollo e Innovación Orientada a los Retos de la Sociedad.Frontiers MediaMinisterio de Economía y Competitividad (España)Ministerio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)European CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120212021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/231340reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2016-77561-Rinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-114148RB-I00PID2020-114148RB-I00/AEI/10.13039/501100011033http://dx.doi.org/10.3389/fcell.2021.629097Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2313402026-05-22T06:33:51Z
dc.title.none.fl_str_mv Role of Actin Cytoskeleton Reorganization in Polarized Secretory Traffic at the Immunological Synapse
title Role of Actin Cytoskeleton Reorganization in Polarized Secretory Traffic at the Immunological Synapse
spellingShingle Role of Actin Cytoskeleton Reorganization in Polarized Secretory Traffic at the Immunological Synapse
Calvo, Victor
T lymphocytes
B lymphocytes
Immune synapse
Actin cytoskeleton
Protein kinase C δ
Centrosomes
Multivesicular bodies
FMNL1
title_short Role of Actin Cytoskeleton Reorganization in Polarized Secretory Traffic at the Immunological Synapse
title_full Role of Actin Cytoskeleton Reorganization in Polarized Secretory Traffic at the Immunological Synapse
title_fullStr Role of Actin Cytoskeleton Reorganization in Polarized Secretory Traffic at the Immunological Synapse
title_full_unstemmed Role of Actin Cytoskeleton Reorganization in Polarized Secretory Traffic at the Immunological Synapse
title_sort Role of Actin Cytoskeleton Reorganization in Polarized Secretory Traffic at the Immunological Synapse
dc.creator.none.fl_str_mv Calvo, Victor
Izquierdo, Manuel
author Calvo, Victor
author_facet Calvo, Victor
Izquierdo, Manuel
author_role author
author2 Izquierdo, Manuel
author2_role author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv T lymphocytes
B lymphocytes
Immune synapse
Actin cytoskeleton
Protein kinase C δ
Centrosomes
Multivesicular bodies
FMNL1
topic T lymphocytes
B lymphocytes
Immune synapse
Actin cytoskeleton
Protein kinase C δ
Centrosomes
Multivesicular bodies
FMNL1
description © 2021 Calvo and Izquierdo.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/231340
url http://hdl.handle.net/10261/231340
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2016-77561-R
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-114148RB-I00
PID2020-114148RB-I00/AEI/10.13039/501100011033
http://dx.doi.org/10.3389/fcell.2021.629097
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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