COVID-19 infection in adult patients with hematological malignancies
Patients with hematological malignancies (HM) are at high risk of mortality from SARS-CoV-2 disease 2019 (COVID-19). A better understanding of risk factors for adverse outcomes may improve clinical management in these patients. We therefore studied baseline characteristics of HM patients developing...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:250480 |
| Acceso en línea: | https://ddd.uab.cat/record/250480 https://dx.doi.org/urn:doi:10.1186/s13045-021-01177-0 |
| Access Level: | acceso abierto |
| Palabra clave: | COVID-19 Pandemic Hematological malignancies Epidemiology EHA |
| id |
ES_05db82dd956d2be14cda3050cbbb83df |
|---|---|
| oai_identifier_str |
oai:ddd.uab.cat:250480 |
| network_acronym_str |
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| network_name_str |
España |
| repository_id_str |
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| dc.title.none.fl_str_mv |
COVID-19 infection in adult patients with hematological malignancies a European Hematology Association Survey (EPICOVIDEHA) |
| title |
COVID-19 infection in adult patients with hematological malignancies |
| spellingShingle |
COVID-19 infection in adult patients with hematological malignancies Pagano, Livio|||0000-0001-8287-928X COVID-19 Pandemic Hematological malignancies Epidemiology EHA |
| title_short |
COVID-19 infection in adult patients with hematological malignancies |
| title_full |
COVID-19 infection in adult patients with hematological malignancies |
| title_fullStr |
COVID-19 infection in adult patients with hematological malignancies |
| title_full_unstemmed |
COVID-19 infection in adult patients with hematological malignancies |
| title_sort |
COVID-19 infection in adult patients with hematological malignancies |
| dc.creator.none.fl_str_mv |
Pagano, Livio|||0000-0001-8287-928X Salmanton-García, Jon|||0000-0002-6766-8297 Marchesi, Francesco|||0000-0001-6353-2272 Busca, Alessandro|||0000-0001-5361-5613 Corradini, Paolo|||0000-0002-9186-1353 Hoenigl, Martin|||0000-0002-1653-2824 Klimko, Nikolai|||0000-0001-6095-7531 Koehler, Philipp|||0000-0002-7386-7495 Pagliuca, Antonio|||0000-0003-2519-0333 Passamonti, Francesco|||0000-0001-8068-5289 Verga, Luisa|||0000-0003-1142-8435 Víšek, Benjamin|||0000-0001-8268-452X Ilhan, Osman|||0000-0003-1665-372X Nadali, Gianpaolo Weinbergerová, Barbora|||0000-0001-6460-2471 Córdoba, Raúl|||0000-0002-7654-8836 Marchetti, Monia|||0000-0001-7615-0572 Collins, Graham|||0000-0002-8803-4234 Farina, Francesca|||0000-0002-5124-6970 Cattaneo, Chiara|||0000-0003-0031-3237 Cabirta, Alba|||0000-0001-7198-8894 Gomes da Silva, Maria|||0000-0002-6993-2450 Itri, Federico|||0000-0002-3532-5281 van Doesum, Jaap A.|||0000-0003-0214-3219 Ledoux, Marie-Pierre|||0000-0002-3261-3616 Čerňan, Martin|||0000-0003-2345-1229 Jakšić, Ozren|||0000-0003-4026-285X Duarte, Rafael|||0000-0002-5240-9815 Magliano, Gabriele|||0000-0002-9129-1530 Omrani, Ali S.|||0000-0001-5309-6358 Fracchiolla, Nicola|||0000-0002-8982-8079 Kulasekararaj, Austin|||0000-0003-3180-3570 Valković, Toni|||0000-0001-6083-8815 Poulsen, Christian Bjørn|||0000-0001-9785-1378 Machado, Marina|||0000-0002-8370-2248 Glenthøj, Andreas|||0000-0003-2082-0738 Stoma, Igor|||0000-0003-0483-7329 Ráčil, Zdeněk|||0000-0003-3511-4596 Piukovics, Klára|||0000-0003-4480-3131 Navrátil, Milan|||0000-0002-2067-1253 Emarah, Ziad|||0000-0003-0622-2598 Sili, Uluhan|||0000-0002-9939-9298 Maertens, Johan|||0000-0003-4257-5980 Blennow, Ola|||0000-0002-7167-7882 Bergantim, Rui|||0000-0002-7811-9509 Garcia-Vidal, Carolina|||0000-0002-8915-0683 Prezioso, Lucia|||0000-0003-1660-4960 Guidetti, Anna|||0000-0002-4195-6397 del Principe, Maria Ilaria|||0000-0002-3958-0669 Popova, Marina|||0000-0001-8536-5495 De Jonge, Nick|||0000-0002-9901-0887 Ormazabal-Vélez, Irati|||0000-0003-1141-5546 Fernández, Noemí Falces-Romero, Iker|||0000-0001-5888-7706 Cuccaro, Annarosa|||0000-0002-0237-1839 Meers, Stef|||0000-0003-1754-2175 Buquicchio, Caterina|||0000-0002-3683-5953 Antić, Darko|||0000-0002-2608-1342 Al-Khabori, Murtadha|||0000-0002-2937-8838 García-Sanz, Ramón|||0000-0003-4120-2787 Biernat, Monika M.|||0000-0003-3161-3398 Tisi, Maria Chiara|||0000-0001-8231-6700 Sal, Ertan|||0000-0003-2761-2675 Rahimli, Laman|||0000-0003-2266-445X Čolović, Natasa Schönlein, Martin|||0000-0002-1010-0975 Calbacho, Maria|||0000-0001-8106-4863 Tascini, Carlo|||0000-0001-9625-6024 Miranda-Castillo, Carolina|||0000-0001-8763-9576 Khanna, Nina|||0000-0002-2642-419X Méndez, Gustavo-Adolfo|||0000-0003-0514-7004 Petzer, Verena|||0000-0002-9205-1440 Novák, Jan Besson, Caroline|||0000-0003-4364-7173 Duléry, Rémy|||0000-0002-5024-1713 Lamure, Sylvain|||0000-0001-5980-305X Nucci, Marcio|||0000-0003-4867-0014 Zambrotta, Giovanni|||0000-0002-8612-2994 Žák, Pavel|||0000-0003-4465-5343 Cengiz Seval, Guldane|||0000-0001-9433-2054 Bonuomo, Valentina|||0000-0001-6491-8337 Mayer, Jiří|||0000-0003-0567-9887 López García, Alberto|||0000-0002-5354-5261 Sacchi, Maria Vittoria|||0000-0001-8133-3357 Booth, Stephen|||0000-0003-2687-0234 Ciceri, Fabio|||0000-0003-0873-0123 Oberti, Margherita Salvini, Marco Izuzquiza, Macarena Nunes Rodrigues, Raquel|||0000-0002-8347-4281 Ammatuna, Emanuele|||0000-0001-8247-4901 Obr, Aleš|||0000-0002-6758-3074 Herbrecht, Raoul|||0000-0002-9381-4876 Núñez-Martín-Buitrago, Lucía Mancini, Valentina Shwaylia, Hawraa|||0000-0002-4098-6092 Sciumè, Mariarita|||0000-0001-7958-4966 Essame, Jenna|||0000-0003-0926-5577 Nygaard, Marietta Batinić, Josip|||0000-0001-5595-9911 Gonzaga, Yung|||0000-0003-1416-2118 Regalado-Artamendi, Isabel|||0000-0002-9673-9015 Karlsson, Linda Katharina|||0000-0003-3317-7550 Shapetska, Maryia|||0000-0002-1223-9161 Hanakova, Michaela El-Ashwah, Shaimaa|||0000-0003-2210-1534 Borbényi, Zita Çolak, Gökçe Melis|||0000-0001-9065-374X Nordlander, Anna Dragonetti, Giulia|||0000-0003-1775-6333 Maraglino, Alessio Maria Edoardo Rinaldi, Amelia|||0000-0002-8211-5076 De Ramón-Sánchez, Cristina|||0000-0002-8167-6410 Cornely, Oliver A.|||0000-0001-9599-3137 |
| author |
Pagano, Livio|||0000-0001-8287-928X |
| author_facet |
Pagano, Livio|||0000-0001-8287-928X Salmanton-García, Jon|||0000-0002-6766-8297 Marchesi, Francesco|||0000-0001-6353-2272 Busca, Alessandro|||0000-0001-5361-5613 Corradini, Paolo|||0000-0002-9186-1353 Hoenigl, Martin|||0000-0002-1653-2824 Klimko, Nikolai|||0000-0001-6095-7531 Koehler, Philipp|||0000-0002-7386-7495 Pagliuca, Antonio|||0000-0003-2519-0333 Passamonti, Francesco|||0000-0001-8068-5289 Verga, Luisa|||0000-0003-1142-8435 Víšek, Benjamin|||0000-0001-8268-452X Ilhan, Osman|||0000-0003-1665-372X Nadali, Gianpaolo Weinbergerová, Barbora|||0000-0001-6460-2471 Córdoba, Raúl|||0000-0002-7654-8836 Marchetti, Monia|||0000-0001-7615-0572 Collins, Graham|||0000-0002-8803-4234 Farina, Francesca|||0000-0002-5124-6970 Cattaneo, Chiara|||0000-0003-0031-3237 Cabirta, Alba|||0000-0001-7198-8894 Gomes da Silva, Maria|||0000-0002-6993-2450 Itri, Federico|||0000-0002-3532-5281 van Doesum, Jaap A.|||0000-0003-0214-3219 Ledoux, Marie-Pierre|||0000-0002-3261-3616 Čerňan, Martin|||0000-0003-2345-1229 Jakšić, Ozren|||0000-0003-4026-285X Duarte, Rafael|||0000-0002-5240-9815 Magliano, Gabriele|||0000-0002-9129-1530 Omrani, Ali S.|||0000-0001-5309-6358 Fracchiolla, Nicola|||0000-0002-8982-8079 Kulasekararaj, Austin|||0000-0003-3180-3570 Valković, Toni|||0000-0001-6083-8815 Poulsen, Christian Bjørn|||0000-0001-9785-1378 Machado, Marina|||0000-0002-8370-2248 Glenthøj, Andreas|||0000-0003-2082-0738 Stoma, Igor|||0000-0003-0483-7329 Ráčil, Zdeněk|||0000-0003-3511-4596 Piukovics, Klára|||0000-0003-4480-3131 Navrátil, Milan|||0000-0002-2067-1253 Emarah, Ziad|||0000-0003-0622-2598 Sili, Uluhan|||0000-0002-9939-9298 Maertens, Johan|||0000-0003-4257-5980 Blennow, Ola|||0000-0002-7167-7882 Bergantim, Rui|||0000-0002-7811-9509 Garcia-Vidal, Carolina|||0000-0002-8915-0683 Prezioso, Lucia|||0000-0003-1660-4960 Guidetti, Anna|||0000-0002-4195-6397 del Principe, Maria Ilaria|||0000-0002-3958-0669 Popova, Marina|||0000-0001-8536-5495 De Jonge, Nick|||0000-0002-9901-0887 Ormazabal-Vélez, Irati|||0000-0003-1141-5546 Fernández, Noemí Falces-Romero, Iker|||0000-0001-5888-7706 Cuccaro, Annarosa|||0000-0002-0237-1839 Meers, Stef|||0000-0003-1754-2175 Buquicchio, Caterina|||0000-0002-3683-5953 Antić, Darko|||0000-0002-2608-1342 Al-Khabori, Murtadha|||0000-0002-2937-8838 García-Sanz, Ramón|||0000-0003-4120-2787 Biernat, Monika M.|||0000-0003-3161-3398 Tisi, Maria Chiara|||0000-0001-8231-6700 Sal, Ertan|||0000-0003-2761-2675 Rahimli, Laman|||0000-0003-2266-445X Čolović, Natasa Schönlein, Martin|||0000-0002-1010-0975 Calbacho, Maria|||0000-0001-8106-4863 Tascini, Carlo|||0000-0001-9625-6024 Miranda-Castillo, Carolina|||0000-0001-8763-9576 Khanna, Nina|||0000-0002-2642-419X Méndez, Gustavo-Adolfo|||0000-0003-0514-7004 Petzer, Verena|||0000-0002-9205-1440 Novák, Jan Besson, Caroline|||0000-0003-4364-7173 Duléry, Rémy|||0000-0002-5024-1713 Lamure, Sylvain|||0000-0001-5980-305X Nucci, Marcio|||0000-0003-4867-0014 Zambrotta, Giovanni|||0000-0002-8612-2994 Žák, Pavel|||0000-0003-4465-5343 Cengiz Seval, Guldane|||0000-0001-9433-2054 Bonuomo, Valentina|||0000-0001-6491-8337 Mayer, Jiří|||0000-0003-0567-9887 López García, Alberto|||0000-0002-5354-5261 Sacchi, Maria Vittoria|||0000-0001-8133-3357 Booth, Stephen|||0000-0003-2687-0234 Ciceri, Fabio|||0000-0003-0873-0123 Oberti, Margherita Salvini, Marco Izuzquiza, Macarena Nunes Rodrigues, Raquel|||0000-0002-8347-4281 Ammatuna, Emanuele|||0000-0001-8247-4901 Obr, Aleš|||0000-0002-6758-3074 Herbrecht, Raoul|||0000-0002-9381-4876 Núñez-Martín-Buitrago, Lucía Mancini, Valentina Shwaylia, Hawraa|||0000-0002-4098-6092 Sciumè, Mariarita|||0000-0001-7958-4966 Essame, Jenna|||0000-0003-0926-5577 Nygaard, Marietta Batinić, Josip|||0000-0001-5595-9911 Gonzaga, Yung|||0000-0003-1416-2118 Regalado-Artamendi, Isabel|||0000-0002-9673-9015 Karlsson, Linda Katharina|||0000-0003-3317-7550 Shapetska, Maryia|||0000-0002-1223-9161 Hanakova, Michaela El-Ashwah, Shaimaa|||0000-0003-2210-1534 Borbényi, Zita Çolak, Gökçe Melis|||0000-0001-9065-374X Nordlander, Anna Dragonetti, Giulia|||0000-0003-1775-6333 Maraglino, Alessio Maria Edoardo Rinaldi, Amelia|||0000-0002-8211-5076 De Ramón-Sánchez, Cristina|||0000-0002-8167-6410 Cornely, Oliver A.|||0000-0001-9599-3137 |
| author_role |
author |
| author2 |
Salmanton-García, Jon|||0000-0002-6766-8297 Marchesi, Francesco|||0000-0001-6353-2272 Busca, Alessandro|||0000-0001-5361-5613 Corradini, Paolo|||0000-0002-9186-1353 Hoenigl, Martin|||0000-0002-1653-2824 Klimko, Nikolai|||0000-0001-6095-7531 Koehler, Philipp|||0000-0002-7386-7495 Pagliuca, Antonio|||0000-0003-2519-0333 Passamonti, Francesco|||0000-0001-8068-5289 Verga, Luisa|||0000-0003-1142-8435 Víšek, Benjamin|||0000-0001-8268-452X Ilhan, Osman|||0000-0003-1665-372X Nadali, Gianpaolo Weinbergerová, Barbora|||0000-0001-6460-2471 Córdoba, Raúl|||0000-0002-7654-8836 Marchetti, Monia|||0000-0001-7615-0572 Collins, Graham|||0000-0002-8803-4234 Farina, Francesca|||0000-0002-5124-6970 Cattaneo, Chiara|||0000-0003-0031-3237 Cabirta, Alba|||0000-0001-7198-8894 Gomes da Silva, Maria|||0000-0002-6993-2450 Itri, Federico|||0000-0002-3532-5281 van Doesum, Jaap A.|||0000-0003-0214-3219 Ledoux, Marie-Pierre|||0000-0002-3261-3616 Čerňan, Martin|||0000-0003-2345-1229 Jakšić, Ozren|||0000-0003-4026-285X Duarte, Rafael|||0000-0002-5240-9815 Magliano, Gabriele|||0000-0002-9129-1530 Omrani, Ali S.|||0000-0001-5309-6358 Fracchiolla, Nicola|||0000-0002-8982-8079 Kulasekararaj, Austin|||0000-0003-3180-3570 Valković, Toni|||0000-0001-6083-8815 Poulsen, Christian Bjørn|||0000-0001-9785-1378 Machado, Marina|||0000-0002-8370-2248 Glenthøj, Andreas|||0000-0003-2082-0738 Stoma, Igor|||0000-0003-0483-7329 Ráčil, Zdeněk|||0000-0003-3511-4596 Piukovics, Klára|||0000-0003-4480-3131 Navrátil, Milan|||0000-0002-2067-1253 Emarah, Ziad|||0000-0003-0622-2598 Sili, Uluhan|||0000-0002-9939-9298 Maertens, Johan|||0000-0003-4257-5980 Blennow, Ola|||0000-0002-7167-7882 Bergantim, Rui|||0000-0002-7811-9509 Garcia-Vidal, Carolina|||0000-0002-8915-0683 Prezioso, Lucia|||0000-0003-1660-4960 Guidetti, Anna|||0000-0002-4195-6397 del Principe, Maria Ilaria|||0000-0002-3958-0669 Popova, Marina|||0000-0001-8536-5495 De Jonge, Nick|||0000-0002-9901-0887 Ormazabal-Vélez, Irati|||0000-0003-1141-5546 Fernández, Noemí Falces-Romero, Iker|||0000-0001-5888-7706 Cuccaro, Annarosa|||0000-0002-0237-1839 Meers, Stef|||0000-0003-1754-2175 Buquicchio, Caterina|||0000-0002-3683-5953 Antić, Darko|||0000-0002-2608-1342 Al-Khabori, Murtadha|||0000-0002-2937-8838 García-Sanz, Ramón|||0000-0003-4120-2787 Biernat, Monika M.|||0000-0003-3161-3398 Tisi, Maria Chiara|||0000-0001-8231-6700 Sal, Ertan|||0000-0003-2761-2675 Rahimli, Laman|||0000-0003-2266-445X Čolović, Natasa Schönlein, Martin|||0000-0002-1010-0975 Calbacho, Maria|||0000-0001-8106-4863 Tascini, Carlo|||0000-0001-9625-6024 Miranda-Castillo, Carolina|||0000-0001-8763-9576 Khanna, Nina|||0000-0002-2642-419X Méndez, Gustavo-Adolfo|||0000-0003-0514-7004 Petzer, Verena|||0000-0002-9205-1440 Novák, Jan Besson, Caroline|||0000-0003-4364-7173 Duléry, Rémy|||0000-0002-5024-1713 Lamure, Sylvain|||0000-0001-5980-305X Nucci, Marcio|||0000-0003-4867-0014 Zambrotta, Giovanni|||0000-0002-8612-2994 Žák, Pavel|||0000-0003-4465-5343 Cengiz Seval, Guldane|||0000-0001-9433-2054 Bonuomo, Valentina|||0000-0001-6491-8337 Mayer, Jiří|||0000-0003-0567-9887 López García, Alberto|||0000-0002-5354-5261 Sacchi, Maria Vittoria|||0000-0001-8133-3357 Booth, Stephen|||0000-0003-2687-0234 Ciceri, Fabio|||0000-0003-0873-0123 Oberti, Margherita Salvini, Marco Izuzquiza, Macarena Nunes Rodrigues, Raquel|||0000-0002-8347-4281 Ammatuna, Emanuele|||0000-0001-8247-4901 Obr, Aleš|||0000-0002-6758-3074 Herbrecht, Raoul|||0000-0002-9381-4876 Núñez-Martín-Buitrago, Lucía Mancini, Valentina Shwaylia, Hawraa|||0000-0002-4098-6092 Sciumè, Mariarita|||0000-0001-7958-4966 Essame, Jenna|||0000-0003-0926-5577 Nygaard, Marietta Batinić, Josip|||0000-0001-5595-9911 Gonzaga, Yung|||0000-0003-1416-2118 Regalado-Artamendi, Isabel|||0000-0002-9673-9015 Karlsson, Linda Katharina|||0000-0003-3317-7550 Shapetska, Maryia|||0000-0002-1223-9161 Hanakova, Michaela El-Ashwah, Shaimaa|||0000-0003-2210-1534 Borbényi, Zita Çolak, Gökçe Melis|||0000-0001-9065-374X Nordlander, Anna Dragonetti, Giulia|||0000-0003-1775-6333 Maraglino, Alessio Maria Edoardo Rinaldi, Amelia|||0000-0002-8211-5076 De Ramón-Sánchez, Cristina|||0000-0002-8167-6410 Cornely, Oliver A.|||0000-0001-9599-3137 |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
COVID-19 Pandemic Hematological malignancies Epidemiology EHA |
| topic |
COVID-19 Pandemic Hematological malignancies Epidemiology EHA |
| description |
Patients with hematological malignancies (HM) are at high risk of mortality from SARS-CoV-2 disease 2019 (COVID-19). A better understanding of risk factors for adverse outcomes may improve clinical management in these patients. We therefore studied baseline characteristics of HM patients developing COVID-19 and analyzed predictors of mortality. The survey was supported by the Scientific Working Group Infection in Hematology of the European Hematology Association (EHA). Eligible for the analysis were adult patients with HM and laboratory-confirmed COVID-19 observed between March and December 2020. The study sample includes 3801 cases, represented by lymphoproliferative (mainly non-Hodgkin lymphoma n = 1084, myeloma n = 684 and chronic lymphoid leukemia n = 474) and myeloproliferative malignancies (mainly acute myeloid leukemia n = 497 and myelodysplastic syndromes n = 279). Severe/critical COVID-19 was observed in 63.8% of patients (n = 2425). Overall, 2778 (73.1%) of the patients were hospitalized, 689 (18.1%) of whom were admitted to intensive care units (ICUs). Overall, 1185 patients (31.2%) died. The primary cause of death was COVID-19 in 688 patients (58.1%), HM in 173 patients (14.6%), and a combination of both COVID-19 and progressing HM in 155 patients (13.1%). Highest mortality was observed in acute myeloid leukemia (199/497, 40%) and myelodysplastic syndromes (118/279, 42.3%). The mortality rate significantly decreased between the first COVID-19 wave (March-May 2020) and the second wave (October-December 2020) (581/1427, 40.7% vs. 439/1773, 24.8%, p value < 0.0001). In the multivariable analysis, age, active malignancy, chronic cardiac disease, liver disease, renal impairment, smoking history, and ICU stay correlated with mortality. Acute myeloid leukemia was a higher mortality risk than lymphoproliferative diseases. This survey confirms that COVID-19 patients with HM are at high risk of lethal complications. However, improved COVID-19 prevention has reduced mortality despite an increase in the number of reported cases. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2 2021-01-01 2021 2021-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/250480 https://dx.doi.org/urn:doi:10.1186/s13045-021-01177-0 |
| url |
https://ddd.uab.cat/record/250480 https://dx.doi.org/urn:doi:10.1186/s13045-021-01177-0 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
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application/pdf |
| dc.source.none.fl_str_mv |
reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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Dipòsit Digital de Documents de la UAB |
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1869402881763835904 |
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COVID-19 infection in adult patients with hematological malignanciesa European Hematology Association Survey (EPICOVIDEHA)Pagano, Livio|||0000-0001-8287-928XSalmanton-García, Jon|||0000-0002-6766-8297Marchesi, Francesco|||0000-0001-6353-2272Busca, Alessandro|||0000-0001-5361-5613Corradini, Paolo|||0000-0002-9186-1353Hoenigl, Martin|||0000-0002-1653-2824Klimko, Nikolai|||0000-0001-6095-7531Koehler, Philipp|||0000-0002-7386-7495Pagliuca, Antonio|||0000-0003-2519-0333Passamonti, Francesco|||0000-0001-8068-5289Verga, Luisa|||0000-0003-1142-8435Víšek, Benjamin|||0000-0001-8268-452XIlhan, Osman|||0000-0003-1665-372XNadali, GianpaoloWeinbergerová, Barbora|||0000-0001-6460-2471Córdoba, Raúl|||0000-0002-7654-8836Marchetti, Monia|||0000-0001-7615-0572Collins, Graham|||0000-0002-8803-4234Farina, Francesca|||0000-0002-5124-6970Cattaneo, Chiara|||0000-0003-0031-3237Cabirta, Alba|||0000-0001-7198-8894Gomes da Silva, Maria|||0000-0002-6993-2450Itri, Federico|||0000-0002-3532-5281van Doesum, Jaap A.|||0000-0003-0214-3219Ledoux, Marie-Pierre|||0000-0002-3261-3616Čerňan, Martin|||0000-0003-2345-1229Jakšić, Ozren|||0000-0003-4026-285XDuarte, Rafael|||0000-0002-5240-9815Magliano, Gabriele|||0000-0002-9129-1530Omrani, Ali S.|||0000-0001-5309-6358Fracchiolla, Nicola|||0000-0002-8982-8079Kulasekararaj, Austin|||0000-0003-3180-3570Valković, Toni|||0000-0001-6083-8815Poulsen, Christian Bjørn|||0000-0001-9785-1378Machado, Marina|||0000-0002-8370-2248Glenthøj, Andreas|||0000-0003-2082-0738Stoma, Igor|||0000-0003-0483-7329Ráčil, Zdeněk|||0000-0003-3511-4596Piukovics, Klára|||0000-0003-4480-3131Navrátil, Milan|||0000-0002-2067-1253Emarah, Ziad|||0000-0003-0622-2598Sili, Uluhan|||0000-0002-9939-9298Maertens, Johan|||0000-0003-4257-5980Blennow, Ola|||0000-0002-7167-7882Bergantim, Rui|||0000-0002-7811-9509Garcia-Vidal, Carolina|||0000-0002-8915-0683Prezioso, Lucia|||0000-0003-1660-4960Guidetti, Anna|||0000-0002-4195-6397del Principe, Maria Ilaria|||0000-0002-3958-0669Popova, Marina|||0000-0001-8536-5495De Jonge, Nick|||0000-0002-9901-0887Ormazabal-Vélez, Irati|||0000-0003-1141-5546Fernández, NoemíFalces-Romero, Iker|||0000-0001-5888-7706Cuccaro, Annarosa|||0000-0002-0237-1839Meers, Stef|||0000-0003-1754-2175Buquicchio, Caterina|||0000-0002-3683-5953Antić, Darko|||0000-0002-2608-1342Al-Khabori, Murtadha|||0000-0002-2937-8838García-Sanz, Ramón|||0000-0003-4120-2787Biernat, Monika M.|||0000-0003-3161-3398Tisi, Maria Chiara|||0000-0001-8231-6700Sal, Ertan|||0000-0003-2761-2675Rahimli, Laman|||0000-0003-2266-445XČolović, NatasaSchönlein, Martin|||0000-0002-1010-0975Calbacho, Maria|||0000-0001-8106-4863Tascini, Carlo|||0000-0001-9625-6024Miranda-Castillo, Carolina|||0000-0001-8763-9576Khanna, Nina|||0000-0002-2642-419XMéndez, Gustavo-Adolfo|||0000-0003-0514-7004Petzer, Verena|||0000-0002-9205-1440Novák, JanBesson, Caroline|||0000-0003-4364-7173Duléry, Rémy|||0000-0002-5024-1713Lamure, Sylvain|||0000-0001-5980-305XNucci, Marcio|||0000-0003-4867-0014Zambrotta, Giovanni|||0000-0002-8612-2994Žák, Pavel|||0000-0003-4465-5343Cengiz Seval, Guldane|||0000-0001-9433-2054Bonuomo, Valentina|||0000-0001-6491-8337Mayer, Jiří|||0000-0003-0567-9887López García, Alberto|||0000-0002-5354-5261Sacchi, Maria Vittoria|||0000-0001-8133-3357Booth, Stephen|||0000-0003-2687-0234Ciceri, Fabio|||0000-0003-0873-0123Oberti, MargheritaSalvini, MarcoIzuzquiza, MacarenaNunes Rodrigues, Raquel|||0000-0002-8347-4281Ammatuna, Emanuele|||0000-0001-8247-4901Obr, Aleš|||0000-0002-6758-3074Herbrecht, Raoul|||0000-0002-9381-4876Núñez-Martín-Buitrago, LucíaMancini, ValentinaShwaylia, Hawraa|||0000-0002-4098-6092Sciumè, Mariarita|||0000-0001-7958-4966Essame, Jenna|||0000-0003-0926-5577Nygaard, MariettaBatinić, Josip|||0000-0001-5595-9911Gonzaga, Yung|||0000-0003-1416-2118Regalado-Artamendi, Isabel|||0000-0002-9673-9015Karlsson, Linda Katharina|||0000-0003-3317-7550Shapetska, Maryia|||0000-0002-1223-9161Hanakova, MichaelaEl-Ashwah, Shaimaa|||0000-0003-2210-1534Borbényi, ZitaÇolak, Gökçe Melis|||0000-0001-9065-374XNordlander, AnnaDragonetti, Giulia|||0000-0003-1775-6333Maraglino, Alessio Maria EdoardoRinaldi, Amelia|||0000-0002-8211-5076De Ramón-Sánchez, Cristina|||0000-0002-8167-6410Cornely, Oliver A.|||0000-0001-9599-3137COVID-19PandemicHematological malignanciesEpidemiologyEHAPatients with hematological malignancies (HM) are at high risk of mortality from SARS-CoV-2 disease 2019 (COVID-19). A better understanding of risk factors for adverse outcomes may improve clinical management in these patients. We therefore studied baseline characteristics of HM patients developing COVID-19 and analyzed predictors of mortality. The survey was supported by the Scientific Working Group Infection in Hematology of the European Hematology Association (EHA). Eligible for the analysis were adult patients with HM and laboratory-confirmed COVID-19 observed between March and December 2020. The study sample includes 3801 cases, represented by lymphoproliferative (mainly non-Hodgkin lymphoma n = 1084, myeloma n = 684 and chronic lymphoid leukemia n = 474) and myeloproliferative malignancies (mainly acute myeloid leukemia n = 497 and myelodysplastic syndromes n = 279). Severe/critical COVID-19 was observed in 63.8% of patients (n = 2425). Overall, 2778 (73.1%) of the patients were hospitalized, 689 (18.1%) of whom were admitted to intensive care units (ICUs). Overall, 1185 patients (31.2%) died. The primary cause of death was COVID-19 in 688 patients (58.1%), HM in 173 patients (14.6%), and a combination of both COVID-19 and progressing HM in 155 patients (13.1%). Highest mortality was observed in acute myeloid leukemia (199/497, 40%) and myelodysplastic syndromes (118/279, 42.3%). The mortality rate significantly decreased between the first COVID-19 wave (March-May 2020) and the second wave (October-December 2020) (581/1427, 40.7% vs. 439/1773, 24.8%, p value < 0.0001). In the multivariable analysis, age, active malignancy, chronic cardiac disease, liver disease, renal impairment, smoking history, and ICU stay correlated with mortality. Acute myeloid leukemia was a higher mortality risk than lymphoproliferative diseases. This survey confirms that COVID-19 patients with HM are at high risk of lethal complications. However, improved COVID-19 prevention has reduced mortality despite an increase in the number of reported cases. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/250480https://dx.doi.org/urn:doi:10.1186/s13045-021-01177-0reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2504802026-06-06T12:50:31Z |
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