Resveratrol Supplementation Attenuates Cognitive and Molecular Alterations under Maternal High-Fat Diet Intake: Epigenetic Inheritance over Generations. Izquierdo V, Palomera-Ávalos V, Pallàs M, Griñán-Ferré C.

Environmental factors such as maternal high-fat diet (HFD) intake can increase the risk of age-related cognitive decline in adult offspring. Epigenetic mechanisms are a possible link between diet effect and neurodegeneration across generations. Here, we found a significant decrease in triglyceride l...

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Autores: Izquierdo, Vanesa, Palomera Ávalos, Verónica, Pallàs i Llibería, Mercè, 1964-, Griñán Ferré, Christian
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/176296
Acceso en línea:https://hdl.handle.net/2445/176296
Access Level:acceso abierto
Palabra clave:Epigenètica
Envelliment
Cognició
Malalties neurodegeneratives
Epigenetics
Aging
Cognition
Neurodegenerative Diseases
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spelling Resveratrol Supplementation Attenuates Cognitive and Molecular Alterations under Maternal High-Fat Diet Intake: Epigenetic Inheritance over Generations. Izquierdo V, Palomera-Ávalos V, Pallàs M, Griñán-Ferré C.Izquierdo, VanesaPalomera Ávalos, VerónicaPallàs i Llibería, Mercè, 1964-Griñán Ferré, ChristianEpigenèticaEnvellimentCognicióMalalties neurodegenerativesEpigeneticsAgingCognitionNeurodegenerative DiseasesEnvironmental factors such as maternal high-fat diet (HFD) intake can increase the risk of age-related cognitive decline in adult offspring. Epigenetic mechanisms are a possible link between diet effect and neurodegeneration across generations. Here, we found a significant decrease in triglyceride levels in a high-fat diet with resveratrol (RSV) HFD + RSV group and the offspring. Firstly, we obtained better cognitive performance in HFD+RSV groups and their offspring. Molecularly, a significant increase in DNA methylation (5-mC) levels, as well as increased gene expression of DNA methyltransferase 1 (Dnmt1) and Dnmt3a in HFD + RSV F1 group, were found. Furthermore, a significant increase of N6-Methyladenosine methylation (m6A) levels in HFD+RSV F1, as well as changes in gene expression of its enzymes Methyltransferase like 3 (Mettl3) and FTO alpha-ketoglutarate dependent dioxygenase (Fto) were found. Moreover, we found a decrease in gene expression levels of proinflammatory markers such as Interleukin 1β (Il1-β), Interleukin 6 (Il-6), Tumor necrosis factor-α (Tnf- α), C-X-C motif chemokine ligand 10 (Cxcl-10), the pro-inflammatory factors monocyte chemoattractant protein 1 (Mcp-1) and Tumor growth factor-β1 (Tgf-β1) in HFD+RSV and HFD+RSV F1 groups. Moreover, there was increased gene expression of neurotrophins such as Neural growth factor (Ngf), Neurotrophin-3 (Nt3), and its receptors Tropomyosin receptor kinase TrkA and TrkB. Likewise, an increase in protein levels of brain-derived neurotrophic factor (BDNF) and phospho-protein kinase B (p-Akt) in HFD+RSV F1 was found. These results suggest that maternal RSV supplementation under HFD intake prevents cognitive decline in senescence-accelerated mice prone 8 (SAMP8) adult offspring, promoting a reduction in triglycerides and leptin plasma levels, changes in the pro-inflammatory profile, and restoring the epigenetic landscape as well as synaptic plasticity.MDPI2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/176296Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/ijms22031453International Journal of Molecular Sciences, 2021, vol. 22, num. 3, p. 1453https://doi.org/10.3390/ijms22031453cc-by (c) Izquierdo, Vanesa et al., 2021http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1762962026-05-27T06:46:51Z
dc.title.none.fl_str_mv Resveratrol Supplementation Attenuates Cognitive and Molecular Alterations under Maternal High-Fat Diet Intake: Epigenetic Inheritance over Generations. Izquierdo V, Palomera-Ávalos V, Pallàs M, Griñán-Ferré C.
title Resveratrol Supplementation Attenuates Cognitive and Molecular Alterations under Maternal High-Fat Diet Intake: Epigenetic Inheritance over Generations. Izquierdo V, Palomera-Ávalos V, Pallàs M, Griñán-Ferré C.
spellingShingle Resveratrol Supplementation Attenuates Cognitive and Molecular Alterations under Maternal High-Fat Diet Intake: Epigenetic Inheritance over Generations. Izquierdo V, Palomera-Ávalos V, Pallàs M, Griñán-Ferré C.
Izquierdo, Vanesa
Epigenètica
Envelliment
Cognició
Malalties neurodegeneratives
Epigenetics
Aging
Cognition
Neurodegenerative Diseases
title_short Resveratrol Supplementation Attenuates Cognitive and Molecular Alterations under Maternal High-Fat Diet Intake: Epigenetic Inheritance over Generations. Izquierdo V, Palomera-Ávalos V, Pallàs M, Griñán-Ferré C.
title_full Resveratrol Supplementation Attenuates Cognitive and Molecular Alterations under Maternal High-Fat Diet Intake: Epigenetic Inheritance over Generations. Izquierdo V, Palomera-Ávalos V, Pallàs M, Griñán-Ferré C.
title_fullStr Resveratrol Supplementation Attenuates Cognitive and Molecular Alterations under Maternal High-Fat Diet Intake: Epigenetic Inheritance over Generations. Izquierdo V, Palomera-Ávalos V, Pallàs M, Griñán-Ferré C.
title_full_unstemmed Resveratrol Supplementation Attenuates Cognitive and Molecular Alterations under Maternal High-Fat Diet Intake: Epigenetic Inheritance over Generations. Izquierdo V, Palomera-Ávalos V, Pallàs M, Griñán-Ferré C.
title_sort Resveratrol Supplementation Attenuates Cognitive and Molecular Alterations under Maternal High-Fat Diet Intake: Epigenetic Inheritance over Generations. Izquierdo V, Palomera-Ávalos V, Pallàs M, Griñán-Ferré C.
dc.creator.none.fl_str_mv Izquierdo, Vanesa
Palomera Ávalos, Verónica
Pallàs i Llibería, Mercè, 1964-
Griñán Ferré, Christian
author Izquierdo, Vanesa
author_facet Izquierdo, Vanesa
Palomera Ávalos, Verónica
Pallàs i Llibería, Mercè, 1964-
Griñán Ferré, Christian
author_role author
author2 Palomera Ávalos, Verónica
Pallàs i Llibería, Mercè, 1964-
Griñán Ferré, Christian
author2_role author
author
author
dc.subject.none.fl_str_mv Epigenètica
Envelliment
Cognició
Malalties neurodegeneratives
Epigenetics
Aging
Cognition
Neurodegenerative Diseases
topic Epigenètica
Envelliment
Cognició
Malalties neurodegeneratives
Epigenetics
Aging
Cognition
Neurodegenerative Diseases
description Environmental factors such as maternal high-fat diet (HFD) intake can increase the risk of age-related cognitive decline in adult offspring. Epigenetic mechanisms are a possible link between diet effect and neurodegeneration across generations. Here, we found a significant decrease in triglyceride levels in a high-fat diet with resveratrol (RSV) HFD + RSV group and the offspring. Firstly, we obtained better cognitive performance in HFD+RSV groups and their offspring. Molecularly, a significant increase in DNA methylation (5-mC) levels, as well as increased gene expression of DNA methyltransferase 1 (Dnmt1) and Dnmt3a in HFD + RSV F1 group, were found. Furthermore, a significant increase of N6-Methyladenosine methylation (m6A) levels in HFD+RSV F1, as well as changes in gene expression of its enzymes Methyltransferase like 3 (Mettl3) and FTO alpha-ketoglutarate dependent dioxygenase (Fto) were found. Moreover, we found a decrease in gene expression levels of proinflammatory markers such as Interleukin 1β (Il1-β), Interleukin 6 (Il-6), Tumor necrosis factor-α (Tnf- α), C-X-C motif chemokine ligand 10 (Cxcl-10), the pro-inflammatory factors monocyte chemoattractant protein 1 (Mcp-1) and Tumor growth factor-β1 (Tgf-β1) in HFD+RSV and HFD+RSV F1 groups. Moreover, there was increased gene expression of neurotrophins such as Neural growth factor (Ngf), Neurotrophin-3 (Nt3), and its receptors Tropomyosin receptor kinase TrkA and TrkB. Likewise, an increase in protein levels of brain-derived neurotrophic factor (BDNF) and phospho-protein kinase B (p-Akt) in HFD+RSV F1 was found. These results suggest that maternal RSV supplementation under HFD intake prevents cognitive decline in senescence-accelerated mice prone 8 (SAMP8) adult offspring, promoting a reduction in triglycerides and leptin plasma levels, changes in the pro-inflammatory profile, and restoring the epigenetic landscape as well as synaptic plasticity.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/176296
url https://hdl.handle.net/2445/176296
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/ijms22031453
International Journal of Molecular Sciences, 2021, vol. 22, num. 3, p. 1453
https://doi.org/10.3390/ijms22031453
dc.rights.none.fl_str_mv cc-by (c) Izquierdo, Vanesa et al., 2021
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Izquierdo, Vanesa et al., 2021
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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