Bacterial Translocation as Inflammatory Driver in Crohn's Disease.

Crohn's disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract responsible for intestinal lesions. The multifactorial etiology attributed to CD includes a combination of environmental and host susceptibility factors, which result in an impaired host-microbe gut interactio...

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Detalles Bibliográficos
Autores: Linares R, Francés R, Gutiérrez A, Juanola O
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p7356
Acceso en línea:https://isabial.portalinvestigacion.com/publicaciones7356
Access Level:acceso abierto
Palabra clave:Crohn’s disease
NOD2
anti-TNF-a
bacterial translocation
dysbiosis
inflammatory response
intestinal permeability
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spelling Bacterial Translocation as Inflammatory Driver in Crohn's Disease.Linares RFrancés RGutiérrez AJuanola OCrohn’s diseaseNOD2anti-TNF-abacterial translocationdysbiosisinflammatory responseintestinal permeabilityCrohn's disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract responsible for intestinal lesions. The multifactorial etiology attributed to CD includes a combination of environmental and host susceptibility factors, which result in an impaired host-microbe gut interaction. Bacterial overgrowth and dysbiosis, increased intestinal barrier permeability, and altered inflammatory responses in patients with CD have been described in the past. Those events explain the pathogenesis of luminal translocation of bacteria or its products into the blood, a frequent event in CD, which, in turn, favors a sustained inflammatory response in these patients. In this review, we navigate through the interaction between bacterial antigen translocation, permeability of the intestinal barrier, immunologic response of the host, and genetic predisposition as a combined effect on the inflammatory response observed in CD. Several lines of evidence support that translocation of bacterial products leads to uncontrolled inflammation in CD patients, and as a matter of fact, the presence of gut bacterial genomic fragments at a systemic level constitutes a marker for increased risk of relapse among CD patients. Also, the significant percentage of CD patients who lose response to biologic therapies may be influenced by the translocation of bacterial products, which are well-known drivers of proinflammatory cytokine production by host immune cells. Further mechanistic studies evaluating cellular and humoral immune responses, gut microbiota alterations, and genetic predisposition will help clinicians to better control and personalize the management of CD patients in the future.FRONTIERS MEDIA SA2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones7356Frontiers in Cell and Developmental BiologyISSN: 2296634Xreponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Inglésinfo:eu-repo/semantics/openAccessoai:isabial.fundanetsuite.com:p73562026-06-12T10:20:37Z
dc.title.none.fl_str_mv Bacterial Translocation as Inflammatory Driver in Crohn's Disease.
title Bacterial Translocation as Inflammatory Driver in Crohn's Disease.
spellingShingle Bacterial Translocation as Inflammatory Driver in Crohn's Disease.
Linares R
Crohn’s disease
NOD2
anti-TNF-a
bacterial translocation
dysbiosis
inflammatory response
intestinal permeability
title_short Bacterial Translocation as Inflammatory Driver in Crohn's Disease.
title_full Bacterial Translocation as Inflammatory Driver in Crohn's Disease.
title_fullStr Bacterial Translocation as Inflammatory Driver in Crohn's Disease.
title_full_unstemmed Bacterial Translocation as Inflammatory Driver in Crohn's Disease.
title_sort Bacterial Translocation as Inflammatory Driver in Crohn's Disease.
dc.creator.none.fl_str_mv Linares R
Francés R
Gutiérrez A
Juanola O
author Linares R
author_facet Linares R
Francés R
Gutiérrez A
Juanola O
author_role author
author2 Francés R
Gutiérrez A
Juanola O
author2_role author
author
author
dc.subject.none.fl_str_mv Crohn’s disease
NOD2
anti-TNF-a
bacterial translocation
dysbiosis
inflammatory response
intestinal permeability
topic Crohn’s disease
NOD2
anti-TNF-a
bacterial translocation
dysbiosis
inflammatory response
intestinal permeability
description Crohn's disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract responsible for intestinal lesions. The multifactorial etiology attributed to CD includes a combination of environmental and host susceptibility factors, which result in an impaired host-microbe gut interaction. Bacterial overgrowth and dysbiosis, increased intestinal barrier permeability, and altered inflammatory responses in patients with CD have been described in the past. Those events explain the pathogenesis of luminal translocation of bacteria or its products into the blood, a frequent event in CD, which, in turn, favors a sustained inflammatory response in these patients. In this review, we navigate through the interaction between bacterial antigen translocation, permeability of the intestinal barrier, immunologic response of the host, and genetic predisposition as a combined effect on the inflammatory response observed in CD. Several lines of evidence support that translocation of bacterial products leads to uncontrolled inflammation in CD patients, and as a matter of fact, the presence of gut bacterial genomic fragments at a systemic level constitutes a marker for increased risk of relapse among CD patients. Also, the significant percentage of CD patients who lose response to biologic therapies may be influenced by the translocation of bacterial products, which are well-known drivers of proinflammatory cytokine production by host immune cells. Further mechanistic studies evaluating cellular and humoral immune responses, gut microbiota alterations, and genetic predisposition will help clinicians to better control and personalize the management of CD patients in the future.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://isabial.portalinvestigacion.com/publicaciones7356
url https://isabial.portalinvestigacion.com/publicaciones7356
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv FRONTIERS MEDIA SA
publisher.none.fl_str_mv FRONTIERS MEDIA SA
dc.source.none.fl_str_mv Frontiers in Cell and Developmental Biology
ISSN: 2296634X
reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
instname_str Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
reponame_str r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
collection r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
repository.name.fl_str_mv
repository.mail.fl_str_mv
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