Rich club organization and cognitive performance in healthy older participants

The human brain is a complex network that has been noted to contain a group of densely interconnected hub regions. With a putative 'rich club' of hubs hypothesized to play a central role in global integrative brain functioning, we assessed whether hub and rich club organizations are associ...

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Detalles Bibliográficos
Autores: Baggio, Hugo César, Segura i Fàbregas, Bàrbara, Junqué i Plaja, Carme, 1955-, Reus, Marcel A. de, Sala Llonch, Roser, Van den Heuvel, Martijn P.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/105665
Acceso en línea:https://hdl.handle.net/2445/105665
Access Level:acceso abierto
Palabra clave:Adults
Cognició
Estimulació del cervell
Envelliment cerebral
Adulthood
Cognition
Brain stimulation
Aging brain
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spelling Rich club organization and cognitive performance in healthy older participantsBaggio, Hugo CésarSegura i Fàbregas, BàrbaraJunqué i Plaja, Carme, 1955-Reus, Marcel A. deSala Llonch, RoserVan den Heuvel, Martijn P.AdultsCognicióEstimulació del cervellEnvelliment cerebralAdulthoodCognitionBrain stimulationAging brainThe human brain is a complex network that has been noted to contain a group of densely interconnected hub regions. With a putative 'rich club' of hubs hypothesized to play a central role in global integrative brain functioning, we assessed whether hub and rich club organizations are associated with cognitive performance in healthy participants and whether the rich club might be differentially involved in cognitive functions with a heavier dependence on global integration. A group of 30 relatively older participants (range = 39-79 years of age) underwent extensive neuropsychological testing, combined with diffusion-weighted magnetic resonance imaging to reconstruct individual structural brain networks. Rich club connectivity was found to be associated with general cognitive performance. More specifically, assessing the relationship between the rich club and performance in two specific cognitive domains, we found rich club connectivity to be differentially associated with attention/executive functions-known to rely on the integration of distributed brain areas-rather than with visuospatial/visuoperceptual functions, which have a more constrained neuroanatomical substrate. Our findings thus provide first empirical evidence of a relevant role played by the rich club in cognitive processes.Massachusetts Institute of Technology Press2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/105665Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1162/jocn_a_00821Journal of Cognitive Neuroscience, 2015, vol. 27, num. 9, p. 1801-1810https://doi.org/10.1162/jocn_a_00821(c) Massachusetts Institute of Technology Press, 2015info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1056652026-05-27T06:46:51Z
dc.title.none.fl_str_mv Rich club organization and cognitive performance in healthy older participants
title Rich club organization and cognitive performance in healthy older participants
spellingShingle Rich club organization and cognitive performance in healthy older participants
Baggio, Hugo César
Adults
Cognició
Estimulació del cervell
Envelliment cerebral
Adulthood
Cognition
Brain stimulation
Aging brain
title_short Rich club organization and cognitive performance in healthy older participants
title_full Rich club organization and cognitive performance in healthy older participants
title_fullStr Rich club organization and cognitive performance in healthy older participants
title_full_unstemmed Rich club organization and cognitive performance in healthy older participants
title_sort Rich club organization and cognitive performance in healthy older participants
dc.creator.none.fl_str_mv Baggio, Hugo César
Segura i Fàbregas, Bàrbara
Junqué i Plaja, Carme, 1955-
Reus, Marcel A. de
Sala Llonch, Roser
Van den Heuvel, Martijn P.
author Baggio, Hugo César
author_facet Baggio, Hugo César
Segura i Fàbregas, Bàrbara
Junqué i Plaja, Carme, 1955-
Reus, Marcel A. de
Sala Llonch, Roser
Van den Heuvel, Martijn P.
author_role author
author2 Segura i Fàbregas, Bàrbara
Junqué i Plaja, Carme, 1955-
Reus, Marcel A. de
Sala Llonch, Roser
Van den Heuvel, Martijn P.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Adults
Cognició
Estimulació del cervell
Envelliment cerebral
Adulthood
Cognition
Brain stimulation
Aging brain
topic Adults
Cognició
Estimulació del cervell
Envelliment cerebral
Adulthood
Cognition
Brain stimulation
Aging brain
description The human brain is a complex network that has been noted to contain a group of densely interconnected hub regions. With a putative 'rich club' of hubs hypothesized to play a central role in global integrative brain functioning, we assessed whether hub and rich club organizations are associated with cognitive performance in healthy participants and whether the rich club might be differentially involved in cognitive functions with a heavier dependence on global integration. A group of 30 relatively older participants (range = 39-79 years of age) underwent extensive neuropsychological testing, combined with diffusion-weighted magnetic resonance imaging to reconstruct individual structural brain networks. Rich club connectivity was found to be associated with general cognitive performance. More specifically, assessing the relationship between the rich club and performance in two specific cognitive domains, we found rich club connectivity to be differentially associated with attention/executive functions-known to rely on the integration of distributed brain areas-rather than with visuospatial/visuoperceptual functions, which have a more constrained neuroanatomical substrate. Our findings thus provide first empirical evidence of a relevant role played by the rich club in cognitive processes.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/105665
url https://hdl.handle.net/2445/105665
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1162/jocn_a_00821
Journal of Cognitive Neuroscience, 2015, vol. 27, num. 9, p. 1801-1810
https://doi.org/10.1162/jocn_a_00821
dc.rights.none.fl_str_mv (c) Massachusetts Institute of Technology Press, 2015
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Massachusetts Institute of Technology Press, 2015
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Massachusetts Institute of Technology Press
publisher.none.fl_str_mv Massachusetts Institute of Technology Press
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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