Cytoskeleton rearrangements during the execution phase of apoptosis

Apoptosis is a regulated energy-dependent process for the elimination of unnecessary or damaged cells during embryonic development, tissue homeostasis and many pathological conditions. Apoptosis is characterized by specific morphological and biochemical features in which caspase activation has a piv...

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Detalles Bibliográficos
Autores: Porcuna, Jesús, Cruz, Patricia de la, Oropesa-Ávila, Manuel, Villanueva-Paz, Marina, Lavera, I. de, Mata, Mario de la, Álvarez-Córdoba, Mónica, Luzón-Hidalgo, Raquel, Suarez-Rivero, Juan M., Cotán, David, Sánchez-Alcázar, José Antonio
Tipo de recurso: otro
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/164098
Acceso en línea:http://hdl.handle.net/10261/164098
Access Level:acceso abierto
Palabra clave:Actin
Apoptosis
Apoptotic microtubule network
Microtubules
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spelling Cytoskeleton rearrangements during the execution phase of apoptosisPorcuna, JesúsCruz, Patricia de laOropesa-Ávila, ManuelVillanueva-Paz, MarinaLavera, I. deMata, Mario de laÁlvarez-Córdoba, MónicaLuzón-Hidalgo, RaquelSuarez-Rivero, Juan M.Cotán, DavidSánchez-Alcázar, José AntonioActinApoptosisApoptotic microtubule networkMicrotubulesApoptosis is a regulated energy-dependent process for the elimination of unnecessary or damaged cells during embryonic development, tissue homeostasis and many pathological conditions. Apoptosis is characterized by specific morphological and biochemical features in which caspase activation has a pivotal role. During apoptosis, cells undergo characteristic morphological reorganizations in which the cytoskeleton participates actively. Traditionally, this cytoskeleton rearrangement has been assigned mainly to actinomyosin ring contraction, with microtubule and intermediate filaments both reported to be depolymerized at early stages of apoptosis. However, recent results have shown that microtubules are reformed during the execution phase of apoptosis forming an apoptotic microtubule network (AMN). Current hypothesis proposes that AMN is required to maintain plasma membrane integrity and cell morphology during the execution phase of apoptosis. AMN disruption provokes apoptotic cell collapse, secondary necrosis and the subsequent release of toxic molecules which can damage surrounding cells and promote inflammation. Therefore, AMN formation in physiological or pathological apoptosis is essential for tissue homeostasis.This work was supported by FIS PI13/00129 grant, Instituto de Salud Carlos III, Spain and Fondo Europeo de Desarrollo Regional (FEDER-Unión Europea), Proyecto de Investigación de Excelencia de la Junta de Andalucía CTS-5725, and by AEPMI (Asociación de Enfermos de Patología Mitocondrial) and ENACH (Asociación de Enfermedades Neurodegenerativas por Acumulación Cerebral de Hierro).Peer ReviewedInTechAsociación de Enfermos de Patologías Mitocondriales (España)European CommissionJunta de AndalucíaENACH AsociaciónInstituto de Salud Carlos IIIConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2018201820162018info:eu-repo/semantics/otherhttp://purl.org/coar/resource_type/c_3248Publisher's versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookParthttp://hdl.handle.net/10261/164098reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.5772/66865Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1640982026-05-22T06:33:51Z
dc.title.none.fl_str_mv Cytoskeleton rearrangements during the execution phase of apoptosis
title Cytoskeleton rearrangements during the execution phase of apoptosis
spellingShingle Cytoskeleton rearrangements during the execution phase of apoptosis
Porcuna, Jesús
Actin
Apoptosis
Apoptotic microtubule network
Microtubules
title_short Cytoskeleton rearrangements during the execution phase of apoptosis
title_full Cytoskeleton rearrangements during the execution phase of apoptosis
title_fullStr Cytoskeleton rearrangements during the execution phase of apoptosis
title_full_unstemmed Cytoskeleton rearrangements during the execution phase of apoptosis
title_sort Cytoskeleton rearrangements during the execution phase of apoptosis
dc.creator.none.fl_str_mv Porcuna, Jesús
Cruz, Patricia de la
Oropesa-Ávila, Manuel
Villanueva-Paz, Marina
Lavera, I. de
Mata, Mario de la
Álvarez-Córdoba, Mónica
Luzón-Hidalgo, Raquel
Suarez-Rivero, Juan M.
Cotán, David
Sánchez-Alcázar, José Antonio
author Porcuna, Jesús
author_facet Porcuna, Jesús
Cruz, Patricia de la
Oropesa-Ávila, Manuel
Villanueva-Paz, Marina
Lavera, I. de
Mata, Mario de la
Álvarez-Córdoba, Mónica
Luzón-Hidalgo, Raquel
Suarez-Rivero, Juan M.
Cotán, David
Sánchez-Alcázar, José Antonio
author_role author
author2 Cruz, Patricia de la
Oropesa-Ávila, Manuel
Villanueva-Paz, Marina
Lavera, I. de
Mata, Mario de la
Álvarez-Córdoba, Mónica
Luzón-Hidalgo, Raquel
Suarez-Rivero, Juan M.
Cotán, David
Sánchez-Alcázar, José Antonio
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Asociación de Enfermos de Patologías Mitocondriales (España)
European Commission
Junta de Andalucía
ENACH Asociación
Instituto de Salud Carlos III
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Actin
Apoptosis
Apoptotic microtubule network
Microtubules
topic Actin
Apoptosis
Apoptotic microtubule network
Microtubules
description Apoptosis is a regulated energy-dependent process for the elimination of unnecessary or damaged cells during embryonic development, tissue homeostasis and many pathological conditions. Apoptosis is characterized by specific morphological and biochemical features in which caspase activation has a pivotal role. During apoptosis, cells undergo characteristic morphological reorganizations in which the cytoskeleton participates actively. Traditionally, this cytoskeleton rearrangement has been assigned mainly to actinomyosin ring contraction, with microtubule and intermediate filaments both reported to be depolymerized at early stages of apoptosis. However, recent results have shown that microtubules are reformed during the execution phase of apoptosis forming an apoptotic microtubule network (AMN). Current hypothesis proposes that AMN is required to maintain plasma membrane integrity and cell morphology during the execution phase of apoptosis. AMN disruption provokes apoptotic cell collapse, secondary necrosis and the subsequent release of toxic molecules which can damage surrounding cells and promote inflammation. Therefore, AMN formation in physiological or pathological apoptosis is essential for tissue homeostasis.
publishDate 2016
dc.date.none.fl_str_mv 2016
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/other
http://purl.org/coar/resource_type/c_3248
Publisher's version
info:eu-repo/semantics/publishedVersion
dc.type.openaire.fl_str_mv info:eu-repo/semantics/bookPart
format other
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/164098
url http://hdl.handle.net/10261/164098
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.5772/66865
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv InTech
publisher.none.fl_str_mv InTech
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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