Role of the NUDT enzymes in breast cancer

The experimental part of this review was supported by Grants from ERC (Project “4D Genome” 609989 and Project “Impacct” 825176), the Spanish Ministery of Science (G62426937 and), the Generalitat de Catalunya (AGAUR SGR 757, 2019PROD00115 and INNOV 00036) and the CRG.

Detalles Bibliográficos
Autores: Wright, Roni, Beato, Miguel
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.12328/3018
Acceso en línea:http://hdl.handle.net/20.500.12328/3018
https://dx.doi.org/10.3390/ijms22052267
Access Level:acceso abierto
Palabra clave:Càncer de pulmó
Descobriment de fàrmacs
Inhibidors
Cèl·lules mare cancerígenes
Receptors hormonals
Metàstasi
Lung cancer
Drug discovery
Inhibitors
Carcinogenic stem cells
Hormone receptors
Metastasis
Cáncer de pulmón
Descubrimiento de fármacos
Inhibidores
Células madre cancerígenas
Receptores hormonales
Metástasis
61
616
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oai_identifier_str oai:recercat.cat:20.500.12328/3018
network_acronym_str ES
network_name_str España
repository_id_str
spelling Role of the NUDT enzymes in breast cancerWright, RoniBeato, MiguelCàncer de pulmóDescobriment de fàrmacsInhibidorsCèl·lules mare cancerígenesReceptors hormonalsMetàstasiLung cancerDrug discoveryInhibitorsCarcinogenic stem cellsHormone receptorsMetastasisCáncer de pulmónDescubrimiento de fármacosInhibidoresCélulas madre cancerígenasReceptores hormonalesMetástasis61616The experimental part of this review was supported by Grants from ERC (Project “4D Genome” 609989 and Project “Impacct” 825176), the Spanish Ministery of Science (G62426937 and), the Generalitat de Catalunya (AGAUR SGR 757, 2019PROD00115 and INNOV 00036) and the CRG.Despite global research efforts, breast cancer remains the leading cause of cancer death in women worldwide. The majority of these deaths are due to metastasis occurring years after the initial treatment of the primary tumor and occurs at a higher frequency in hormone receptor-positive (Estrogen and Progesterone; HR+) breast cancers. We have previously described the role of NUDT5 (Nudix-linked to moiety X-5) in HR+ breast cancer progression, specifically with regards to the growth of breast cancer stem cells (BCSCs). BCSCs are known to be the initiators of epithelial-to-mesenchyme transition (EMT), metastatic colonization, and growth. Therefore, a greater understanding of the proteins and signaling pathways involved in the metastatic process may open the door for therapeutic opportunities. In this review, we discuss the role of NUDT5 and other members of the NUDT family of enzymes in breast and other cancer types. We highlight the use of global omics data based on our recent phosphoproteomic analysis of progestin signaling pathways in breast cancer cells and how this experimental approach provides insight into novel crosstalk mechanisms for stratification and drug discovery projects aiming to treat patients with aggressive cancer.info:eu-repo/semantics/publishedVersionMDPI2021info:eu-repo/semantics/article14http://hdl.handle.net/20.500.12328/3018https://dx.doi.org/10.3390/ijms22052267reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésInternational Journal of Molecular Sciences22;5This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.12328/30182026-05-29T05:05:01Z
dc.title.none.fl_str_mv Role of the NUDT enzymes in breast cancer
title Role of the NUDT enzymes in breast cancer
spellingShingle Role of the NUDT enzymes in breast cancer
Wright, Roni
Càncer de pulmó
Descobriment de fàrmacs
Inhibidors
Cèl·lules mare cancerígenes
Receptors hormonals
Metàstasi
Lung cancer
Drug discovery
Inhibitors
Carcinogenic stem cells
Hormone receptors
Metastasis
Cáncer de pulmón
Descubrimiento de fármacos
Inhibidores
Células madre cancerígenas
Receptores hormonales
Metástasis
61
616
title_short Role of the NUDT enzymes in breast cancer
title_full Role of the NUDT enzymes in breast cancer
title_fullStr Role of the NUDT enzymes in breast cancer
title_full_unstemmed Role of the NUDT enzymes in breast cancer
title_sort Role of the NUDT enzymes in breast cancer
dc.creator.none.fl_str_mv Wright, Roni
Beato, Miguel
author Wright, Roni
author_facet Wright, Roni
Beato, Miguel
author_role author
author2 Beato, Miguel
author2_role author
dc.subject.none.fl_str_mv Càncer de pulmó
Descobriment de fàrmacs
Inhibidors
Cèl·lules mare cancerígenes
Receptors hormonals
Metàstasi
Lung cancer
Drug discovery
Inhibitors
Carcinogenic stem cells
Hormone receptors
Metastasis
Cáncer de pulmón
Descubrimiento de fármacos
Inhibidores
Células madre cancerígenas
Receptores hormonales
Metástasis
61
616
topic Càncer de pulmó
Descobriment de fàrmacs
Inhibidors
Cèl·lules mare cancerígenes
Receptors hormonals
Metàstasi
Lung cancer
Drug discovery
Inhibitors
Carcinogenic stem cells
Hormone receptors
Metastasis
Cáncer de pulmón
Descubrimiento de fármacos
Inhibidores
Células madre cancerígenas
Receptores hormonales
Metástasis
61
616
description The experimental part of this review was supported by Grants from ERC (Project “4D Genome” 609989 and Project “Impacct” 825176), the Spanish Ministery of Science (G62426937 and), the Generalitat de Catalunya (AGAUR SGR 757, 2019PROD00115 and INNOV 00036) and the CRG.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12328/3018
https://dx.doi.org/10.3390/ijms22052267
url http://hdl.handle.net/20.500.12328/3018
https://dx.doi.org/10.3390/ijms22052267
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International Journal of Molecular Sciences
22;5
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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