Osteointegration characterization of titanium biofunctionalized with drug-loaded nanoparticules implanted in a diabetic animal model
Type II diabetes mellitus is the most common metabolic disorder and represents a contraindication for optimal orthopaedic implant treatment since it is considered to be directly related to decrease bone regeneration capacities. Resveratrol is an anti-diabetic drug and Nifedipine is a calcium channel...
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| Tipo de recurso: | tesis de maestría |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/367147 |
| Acceso en línea: | https://hdl.handle.net/2117/367147 |
| Access Level: | acceso abierto |
| Palabra clave: | Diabetes Resveratrol Implants, Artificial osteointegration resveratrol nifedipine biofunctionalization diabetes Diabetis Implants artificials Àrees temàtiques de la UPC::Enginyeria biomèdica |
| Sumario: | Type II diabetes mellitus is the most common metabolic disorder and represents a contraindication for optimal orthopaedic implant treatment since it is considered to be directly related to decrease bone regeneration capacities. Resveratrol is an anti-diabetic drug and Nifedipine is a calcium channel blocker, both demonstrated promotion of bone formation. Therefore, they have been encapsuled in nanoparticles to biofunctionalize implants in order to improve osteointegration capacities. Previously to this work, 40 genetically modified BBDR rats have been implanted with a dental implant in each tibia. One leg has received a control implant (nanoparticles decorated with peptides) and the other an implant biofonctionalized with drug-loaded nanoparticles decorated with peptides, either loaded with resveratrol or with nifedipine. For each condition, at three different implantation times (4,8 and 12 weeks), the osteointegration has been characterized using BIC value calculations and histological and histomorphometrical analyses. The statistical analysis of the BIC values does not show any significant difference between each condition. However, the drug-loaded nanoparticles show higher BIC values only after short times compared to the control. The histological analysis does not present any evident difference between each condition at each time, only the resveratrol group seem to have a slighty better neobone formation. These results indicated that neither resveratrol nor nifedipine loaded in nanoparticles as biofunctionalization enhances osteointegration in a significant way. A dose-dependant effect might be further studied. |
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