Vitamin D-Related Genes, Blood Vitamin D Levels and Colorectal Cancer Risk in Western European Populations

Fedirko, Veronika; Mandle, Hannah B.; Zhu, Wanzhe; Hughes, David J.; Siddiq, Afshan; Ferrari, Pietro; Romieu, Isabelle; Riboli, Elio; Bueno de Mesquita, H. Bas; van Duijnhoven, Franzel J. B.; Siersema, Peter D.; Tjønneland, Anne; Olsen, Anja; Perduca, Vittorio; Carbonnel, Franck; Boutron-Ruault, Marie-Christine; Kühn, Tilman; Johnson, Theron; Krasimira, Aleksandrova; Trichopoulou, Antonia; Makrythanasis, Periklis; Thanos, Dimitris; Panico, Salvatore; Krogh, Vittorio; Sacerdote, Carlotta; Skeie, Guri; Weiderpass, Elisabete; Colorado-Yohar, Sandra; Sala Serra, Núria; Barricarte, Aurelio; Sánchez, María José; Quirós, José Ramón; Amiano, Pilar; Gylling, Björn; Harlid, Sophia; Pérez Cornago, Aurora; Heath, Alicia K.; Tsilidis, Konstantinos K.; Aune, Dagfinn; Freisling, Heinz; Murphy, Neil; Gunter, Marc J.; Jenab, Mazda

Vitamin D-Related Genes, Blood Vitamin D Levels and Colorectal Cancer Risk in Western European Populations

Higher circulating 25-hydroxyvitamin D levels (25(OH)D) have been found to be associated with lower risk for colorectal cancer (CRC) in prospective studies. Whether this association is modified by genetic variation in genes related to vitamin D metabolism and action has not been well studied in huma...

Descripción completa

Detalles Bibliográficos
Autores:	Fedirko, Veronika, Mandle, Hannah B., Zhu, Wanzhe, Hughes, David J., Siddiq, Afshan, Ferrari, Pietro, Romieu, Isabelle, Riboli, Elio, Bueno de Mesquita, H. Bas, van Duijnhoven, Franzel J. B., Siersema, Peter D., Tjønneland, Anne, Olsen, Anja, Perduca, Vittorio, Carbonnel, Franck, Boutron-Ruault, Marie-Christine, Kühn, Tilman, Johnson, Theron, Krasimira, Aleksandrova, Trichopoulou, Antonia, Makrythanasis, Periklis, Thanos, Dimitris, Panico, Salvatore, Krogh, Vittorio, Sacerdote, Carlotta, Skeie, Guri, Weiderpass, Elisabete, Colorado-Yohar, Sandra, Sala Serra, Núria, Barricarte, Aurelio, Sánchez, María José, Quirós, José Ramón, Amiano, Pilar, Gylling, Björn, Harlid, Sophia, Pérez Cornago, Aurora, Heath, Alicia K., Tsilidis, Konstantinos K., Aune, Dagfinn, Freisling, Heinz, Murphy, Neil, Gunter, Marc J., Jenab, Mazda
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2019
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/171425
Acceso en línea:	https://hdl.handle.net/2445/171425
Access Level:	acceso abierto
Palabra clave:	Càncer colorectal Vitamina D Colorectal cancer Vitamin D

id	ES_054dc76ccef766f685bcdbfeb7f246ae
oai_identifier_str	oai:recercat.cat:2445/171425
network_acronym_str	ES
network_name_str	España
repository_id_str
spelling	Vitamin D-Related Genes, Blood Vitamin D Levels and Colorectal Cancer Risk in Western European PopulationsFedirko, VeronikaMandle, Hannah B.Zhu, WanzheHughes, David J.Siddiq, AfshanFerrari, PietroRomieu, IsabelleRiboli, ElioBueno de Mesquita, H. Basvan Duijnhoven, Franzel J. B.Siersema, Peter D.Tjønneland, AnneOlsen, AnjaPerduca, VittorioCarbonnel, FranckBoutron-Ruault, Marie-ChristineKühn, TilmanJohnson, TheronKrasimira, AleksandrovaTrichopoulou, AntoniaMakrythanasis, PeriklisThanos, DimitrisPanico, SalvatoreKrogh, VittorioSacerdote, CarlottaSkeie, GuriWeiderpass, ElisabeteColorado-Yohar, SandraSala Serra, NúriaBarricarte, AurelioSánchez, María JoséQuirós, José RamónAmiano, PilarGylling, BjörnHarlid, SophiaPérez Cornago, AuroraHeath, Alicia K.Tsilidis, Konstantinos K.Aune, DagfinnFreisling, HeinzMurphy, NeilGunter, Marc J.Jenab, MazdaCàncer colorectalVitamina DColorectal cancerVitamin DHigher circulating 25-hydroxyvitamin D levels (25(OH)D) have been found to be associated with lower risk for colorectal cancer (CRC) in prospective studies. Whether this association is modified by genetic variation in genes related to vitamin D metabolism and action has not been well studied in humans. We investigated 1307 functional and tagging single-nucleotide polymorphisms (SNPs; individually, and by gene/pathway) in 86 vitamin D-related genes in 1420 incident CRC cases matched to controls from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. We also evaluated the association between these SNPs and circulating 25(OH)D in a subset of controls. We confirmed previously reported CRC risk associations between SNPs in the VDR, GC, and CYP27B1 genes. We also identified additional associations with 25(OH)D, as well as CRC risk, and several potentially novel SNPs in genes related to vitamin D transport and action (LRP2, CUBN, NCOA7, and HDAC9). However, none of these SNPs were statistically significant after Benjamini-Hochberg (BH) multiple testing correction. When assessed by a priori defined functional pathways, tumor growth factor beta (TGF beta) signaling was associated with CRC risk (P <= 0.001), with most statistically significant genes being SMAD7 (P-BH = 0.008) and SMAD3 (P-BH = 0.008), and 18 SNPs in the vitamin D receptor (VDR) binding sites (P = 0.036). The 25(OH)D-gene pathway analysis suggested that genetic variants in the genes related to VDR complex formation and transcriptional activity are associated with CRC depending on 25(OH)D levels (interaction P = 0.041). Additional studies in large populations and consortia, especially with measured circulating 25(OH)D, are needed to confirm our findings.MDPI2020202020192020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion24 p.application/pdfhttps://hdl.handle.net/2445/171425Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/nu11081954Nutrients, 2019, vol. 11, num. 8, p. 1954https://doi.org/10.3390/nu11081954cc by (c) Fedirko et al., 2019http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1714252026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Vitamin D-Related Genes, Blood Vitamin D Levels and Colorectal Cancer Risk in Western European Populations
title	Vitamin D-Related Genes, Blood Vitamin D Levels and Colorectal Cancer Risk in Western European Populations
spellingShingle	Vitamin D-Related Genes, Blood Vitamin D Levels and Colorectal Cancer Risk in Western European Populations Fedirko, Veronika Càncer colorectal Vitamina D Colorectal cancer Vitamin D
title_short	Vitamin D-Related Genes, Blood Vitamin D Levels and Colorectal Cancer Risk in Western European Populations
title_full	Vitamin D-Related Genes, Blood Vitamin D Levels and Colorectal Cancer Risk in Western European Populations
title_fullStr	Vitamin D-Related Genes, Blood Vitamin D Levels and Colorectal Cancer Risk in Western European Populations
title_full_unstemmed	Vitamin D-Related Genes, Blood Vitamin D Levels and Colorectal Cancer Risk in Western European Populations
title_sort	Vitamin D-Related Genes, Blood Vitamin D Levels and Colorectal Cancer Risk in Western European Populations
dc.creator.none.fl_str_mv	Fedirko, Veronika Mandle, Hannah B. Zhu, Wanzhe Hughes, David J. Siddiq, Afshan Ferrari, Pietro Romieu, Isabelle Riboli, Elio Bueno de Mesquita, H. Bas van Duijnhoven, Franzel J. B. Siersema, Peter D. Tjønneland, Anne Olsen, Anja Perduca, Vittorio Carbonnel, Franck Boutron-Ruault, Marie-Christine Kühn, Tilman Johnson, Theron Krasimira, Aleksandrova Trichopoulou, Antonia Makrythanasis, Periklis Thanos, Dimitris Panico, Salvatore Krogh, Vittorio Sacerdote, Carlotta Skeie, Guri Weiderpass, Elisabete Colorado-Yohar, Sandra Sala Serra, Núria Barricarte, Aurelio Sánchez, María José Quirós, José Ramón Amiano, Pilar Gylling, Björn Harlid, Sophia Pérez Cornago, Aurora Heath, Alicia K. Tsilidis, Konstantinos K. Aune, Dagfinn Freisling, Heinz Murphy, Neil Gunter, Marc J. Jenab, Mazda
author	Fedirko, Veronika
author_facet	Fedirko, Veronika Mandle, Hannah B. Zhu, Wanzhe Hughes, David J. Siddiq, Afshan Ferrari, Pietro Romieu, Isabelle Riboli, Elio Bueno de Mesquita, H. Bas van Duijnhoven, Franzel J. B. Siersema, Peter D. Tjønneland, Anne Olsen, Anja Perduca, Vittorio Carbonnel, Franck Boutron-Ruault, Marie-Christine Kühn, Tilman Johnson, Theron Krasimira, Aleksandrova Trichopoulou, Antonia Makrythanasis, Periklis Thanos, Dimitris Panico, Salvatore Krogh, Vittorio Sacerdote, Carlotta Skeie, Guri Weiderpass, Elisabete Colorado-Yohar, Sandra Sala Serra, Núria Barricarte, Aurelio Sánchez, María José Quirós, José Ramón Amiano, Pilar Gylling, Björn Harlid, Sophia Pérez Cornago, Aurora Heath, Alicia K. Tsilidis, Konstantinos K. Aune, Dagfinn Freisling, Heinz Murphy, Neil Gunter, Marc J. Jenab, Mazda
author_role	author
author2	Mandle, Hannah B. Zhu, Wanzhe Hughes, David J. Siddiq, Afshan Ferrari, Pietro Romieu, Isabelle Riboli, Elio Bueno de Mesquita, H. Bas van Duijnhoven, Franzel J. B. Siersema, Peter D. Tjønneland, Anne Olsen, Anja Perduca, Vittorio Carbonnel, Franck Boutron-Ruault, Marie-Christine Kühn, Tilman Johnson, Theron Krasimira, Aleksandrova Trichopoulou, Antonia Makrythanasis, Periklis Thanos, Dimitris Panico, Salvatore Krogh, Vittorio Sacerdote, Carlotta Skeie, Guri Weiderpass, Elisabete Colorado-Yohar, Sandra Sala Serra, Núria Barricarte, Aurelio Sánchez, María José Quirós, José Ramón Amiano, Pilar Gylling, Björn Harlid, Sophia Pérez Cornago, Aurora Heath, Alicia K. Tsilidis, Konstantinos K. Aune, Dagfinn Freisling, Heinz Murphy, Neil Gunter, Marc J. Jenab, Mazda
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Càncer colorectal Vitamina D Colorectal cancer Vitamin D
topic	Càncer colorectal Vitamina D Colorectal cancer Vitamin D
description	Higher circulating 25-hydroxyvitamin D levels (25(OH)D) have been found to be associated with lower risk for colorectal cancer (CRC) in prospective studies. Whether this association is modified by genetic variation in genes related to vitamin D metabolism and action has not been well studied in humans. We investigated 1307 functional and tagging single-nucleotide polymorphisms (SNPs; individually, and by gene/pathway) in 86 vitamin D-related genes in 1420 incident CRC cases matched to controls from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. We also evaluated the association between these SNPs and circulating 25(OH)D in a subset of controls. We confirmed previously reported CRC risk associations between SNPs in the VDR, GC, and CYP27B1 genes. We also identified additional associations with 25(OH)D, as well as CRC risk, and several potentially novel SNPs in genes related to vitamin D transport and action (LRP2, CUBN, NCOA7, and HDAC9). However, none of these SNPs were statistically significant after Benjamini-Hochberg (BH) multiple testing correction. When assessed by a priori defined functional pathways, tumor growth factor beta (TGF beta) signaling was associated with CRC risk (P <= 0.001), with most statistically significant genes being SMAD7 (P-BH = 0.008) and SMAD3 (P-BH = 0.008), and 18 SNPs in the vitamin D receptor (VDR) binding sites (P = 0.036). The 25(OH)D-gene pathway analysis suggested that genetic variants in the genes related to VDR complex formation and transcriptional activity are associated with CRC depending on 25(OH)D levels (interaction P = 0.041). Additional studies in large populations and consortia, especially with measured circulating 25(OH)D, are needed to confirm our findings.
publishDate	2019
dc.date.none.fl_str_mv	2019 2020 2020 2020
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/171425
url	https://hdl.handle.net/2445/171425
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.3390/nu11081954 Nutrients, 2019, vol. 11, num. 8, p. 1954 https://doi.org/10.3390/nu11081954
dc.rights.none.fl_str_mv	cc by (c) Fedirko et al., 2019 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc by (c) Fedirko et al., 2019 http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	24 p. application/pdf
dc.publisher.none.fl_str_mv	MDPI
publisher.none.fl_str_mv	MDPI
dc.source.none.fl_str_mv	Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_	1869402847111544832
score	15,811543

Vitamin D-Related Genes, Blood Vitamin D Levels and Colorectal Cancer Risk in Western European Populations

Similares en LA Referencia