Changes in the Composition and Function of Lipoproteins after Bariatric Surgery in Patients with Severe Obesity

The effect of bariatric surgery on lipid profile and the qualitative characteristics of lipoproteins was analyzed in morbidly obese subjects. Thirteen obese patients underwent bariatric surgery. Plasma samples were obtained before surgery and at 6 and 12 months after the intervention. Thirteen healt...

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Detalles Bibliográficos
Autores: Genua, Idoia|||0000-0001-6834-561X, Puig Grifol, Núria|||0000-0002-4699-3162, Miñambres, Inka|||0000-0002-0899-3938, Benitez, Sonia|||0000-0003-3565-0743, Gil, Pedro|||0000-0003-3707-7450, Grau-Agramunt, Margarida, Rivas-Urbina, Andrea|||0000-0002-0111-0477, Balagué Ponz, Carmen|||0000-0003-2429-8297, Fernández-Alanin, Sonia, García Osuna, Álvaro|||0000-0002-6682-0226, Pérez, Antonio|||0000-0001-5528-1143, Sánchez Quesada, José Luis|||0000-0003-0224-591X
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:255522
Acceso en línea:https://ddd.uab.cat/record/255522
https://dx.doi.org/urn:doi:10.3390/jcm10081716
Access Level:acceso abierto
Palabra clave:Obesity
Bariatric surgery
Lipoproteins
Lipoprotein function
LDL
HDL
Apolipoproteins
Descripción
Sumario:The effect of bariatric surgery on lipid profile and the qualitative characteristics of lipoproteins was analyzed in morbidly obese subjects. Thirteen obese patients underwent bariatric surgery. Plasma samples were obtained before surgery and at 6 and 12 months after the intervention. Thirteen healthy subjects comprised the control group. Lipid profile, hsCRP, and the composition and functional characteristics of VLDL, LDL, and HDL were assessed. At baseline, plasma from subjects with obesity had more triglycerides, VLDLc, and hsCRP, and less HDLc than the control group. These levels progressively normalized after surgery, although triglyceride and hsCRP levels remained higher than those in the controls. The main differences in lipoprotein composition between the obese subjects and the controls were increased apoE in VLDL, and decreased cholesterol and apoJ and increased apoC-III content in HDL. The pro-/anti-atherogenic properties of LDL and HDL were altered in the subjects with obesity at baseline compared with the controls, presenting smaller LDL particles that are more susceptible to modification and smaller HDL particles with decreased antioxidant capacity. Bariatric surgery normalized the composition of lipoproteins and improved the qualitative characteristics of LDL and HDL. In summary, patients with obesity present multiple alterations in the qualitative properties of lipoproteins compared with healthy subjects. Bariatric surgery reverted most of these alterations.

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