3D-printed Laponite/Alginate hydrogel-based suppositories for versatile drug loading and release

Traditional approaches to solid rectal therapies have halted progress, leading to a continual decline in the use of conventional suppositories. Additive manufacturing techniques have been recently explored as a suitable innovative tool for supposi- tory fabrication. However, little advancement has b...

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Autores: Muñoz Pérez, Elena, Rubio Retama, Jorge, Cussó, Lorena, Igartua Olaechea, Manuela, Hernández Martín, Rosa María, Santos Vizcaíno, Edorta
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/73039
Acceso en línea:http://hdl.handle.net/10810/73039
Access Level:acceso abierto
Palabra clave:3D printing
semi-solid extrusion
laponite
alginate
drug-delivery
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spelling 3D-printed Laponite/Alginate hydrogel-based suppositories for versatile drug loading and releaseMuñoz Pérez, ElenaRubio Retama, JorgeCussó, LorenaIgartua Olaechea, ManuelaHernández Martín, Rosa MaríaSantos Vizcaíno, Edorta3D printingsemi-solid extrusionlaponitealginatedrug-deliveryTraditional approaches to solid rectal therapies have halted progress, leading to a continual decline in the use of conventional suppositories. Additive manufacturing techniques have been recently explored as a suitable innovative tool for supposi- tory fabrication. However, little advancement has been made in composition materials for 3D-printed suppository (3DPS) manufacturing and still, conventional vehicles are often used for construct fabrication, hindering the growth in the field. As a novelty, this study unveils a ground-breaking Laponite-alginate hydrogel-based 3DPS. Interestingly, this study proposes a novel approach for loading drugs into the 3DPS employing for the first time the post-printing loading. Thus, a passive loading strategy of molecular models is developed, demonstrating the versatility and capacity to load molecules of different charges and molecular sizes within the matrix systems. This novel strategy allows adapting the load of a wide range of drugs into a single ink, which simplifies and speeds up the 3DPS technological development process for drugs with different physico- chemical properties. Additionally, in this research, a displacement strategy of the three-dimensional Laponite matrices is developed in order to enhance the drug release capacity through the 3DPS and their disintegration capacity, resulting in a significant improvement of the drug diffusion through the hydrogel matrix and a rapid disintegration of the 3DPS. Finally, our study demonstrates that the obtained 3DPS have a suitable in vivo behavior, being non-obstructive and allowing the normal motility of the rats intestine.Open Access funding provided thanks to the CRUE-CSIC agree- ment with Springer Nature. This project has been supported by the grant PID2021-122577OB-I00 and PID2021-123318-OB-I00 funded by MCIN/ AEI/ 10.13039/501100011033 and by “ERDF A way of making Europe”. Also financed by the Fundación Vital Fundazioa (vital21/28), the Basque Government (grant IT1448-22 and PRE_2022_2_0115) and Comunidad de Madrid (S2022/BMD-7403 RENIM-CM). Finally, this work was sup- ported by Instituto de Salud Carlos III (PT20/00044), co-financed by the European Union, European Regional Development Fund (ERDF, A way to make Europe).Springer Nature202520252024info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/73039reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/grantAgreement/MICINN/PID2021-122577OB-I00/info:eu-repo/grantAgreement/MICINN/PID2021-123318-OB-I00/https://link.springer.com/article/10.1007/s13346-023-01506-5info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/© The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International LicenseAtribución 3.0 Españaoai:addi.ehu.eus:10810/730392026-06-18T09:23:17Z
dc.title.none.fl_str_mv 3D-printed Laponite/Alginate hydrogel-based suppositories for versatile drug loading and release
title 3D-printed Laponite/Alginate hydrogel-based suppositories for versatile drug loading and release
spellingShingle 3D-printed Laponite/Alginate hydrogel-based suppositories for versatile drug loading and release
Muñoz Pérez, Elena
3D printing
semi-solid extrusion
laponite
alginate
drug-delivery
title_short 3D-printed Laponite/Alginate hydrogel-based suppositories for versatile drug loading and release
title_full 3D-printed Laponite/Alginate hydrogel-based suppositories for versatile drug loading and release
title_fullStr 3D-printed Laponite/Alginate hydrogel-based suppositories for versatile drug loading and release
title_full_unstemmed 3D-printed Laponite/Alginate hydrogel-based suppositories for versatile drug loading and release
title_sort 3D-printed Laponite/Alginate hydrogel-based suppositories for versatile drug loading and release
dc.creator.none.fl_str_mv Muñoz Pérez, Elena
Rubio Retama, Jorge
Cussó, Lorena
Igartua Olaechea, Manuela
Hernández Martín, Rosa María
Santos Vizcaíno, Edorta
author Muñoz Pérez, Elena
author_facet Muñoz Pérez, Elena
Rubio Retama, Jorge
Cussó, Lorena
Igartua Olaechea, Manuela
Hernández Martín, Rosa María
Santos Vizcaíno, Edorta
author_role author
author2 Rubio Retama, Jorge
Cussó, Lorena
Igartua Olaechea, Manuela
Hernández Martín, Rosa María
Santos Vizcaíno, Edorta
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv 3D printing
semi-solid extrusion
laponite
alginate
drug-delivery
topic 3D printing
semi-solid extrusion
laponite
alginate
drug-delivery
description Traditional approaches to solid rectal therapies have halted progress, leading to a continual decline in the use of conventional suppositories. Additive manufacturing techniques have been recently explored as a suitable innovative tool for supposi- tory fabrication. However, little advancement has been made in composition materials for 3D-printed suppository (3DPS) manufacturing and still, conventional vehicles are often used for construct fabrication, hindering the growth in the field. As a novelty, this study unveils a ground-breaking Laponite-alginate hydrogel-based 3DPS. Interestingly, this study proposes a novel approach for loading drugs into the 3DPS employing for the first time the post-printing loading. Thus, a passive loading strategy of molecular models is developed, demonstrating the versatility and capacity to load molecules of different charges and molecular sizes within the matrix systems. This novel strategy allows adapting the load of a wide range of drugs into a single ink, which simplifies and speeds up the 3DPS technological development process for drugs with different physico- chemical properties. Additionally, in this research, a displacement strategy of the three-dimensional Laponite matrices is developed in order to enhance the drug release capacity through the 3DPS and their disintegration capacity, resulting in a significant improvement of the drug diffusion through the hydrogel matrix and a rapid disintegration of the 3DPS. Finally, our study demonstrates that the obtained 3DPS have a suitable in vivo behavior, being non-obstructive and allowing the normal motility of the rats intestine.
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/73039
url http://hdl.handle.net/10810/73039
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MICINN/PID2021-122577OB-I00/
info:eu-repo/grantAgreement/MICINN/PID2021-123318-OB-I00/
https://link.springer.com/article/10.1007/s13346-023-01506-5
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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