The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of Psychosis
Background: premorbid IQ (pIQ) and age of onset are predictors of clinical severity and long-term functioning after a first episode of psychosis. However, the additive influence of these variables on clinical, functional, and recovery rates outcomes is largely unknown. Methods: we characterized 255...
| Autores: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:256433 |
| Acceso en línea: | https://ddd.uab.cat/record/256433 https://dx.doi.org/urn:doi:10.3390/jcm10112474 |
| Access Level: | acceso abierto |
| Palabra clave: | Psychosis First-episode Premorbid intelligence Age at onset Functional outcome Remission Recovery Heterogeneity Subgroup |
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The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of Psychosis |
| title |
The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of Psychosis |
| spellingShingle |
The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of Psychosis Molina-García, Mariola Psychosis First-episode Premorbid intelligence Age at onset Functional outcome Remission Recovery Heterogeneity Subgroup |
| title_short |
The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of Psychosis |
| title_full |
The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of Psychosis |
| title_fullStr |
The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of Psychosis |
| title_full_unstemmed |
The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of Psychosis |
| title_sort |
The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of Psychosis |
| dc.creator.none.fl_str_mv |
Molina-García, Mariola Fraguas, David|||0000-0002-7931-2933 del Rey-Mejías, Ángel|||0000-0003-1690-3215 Mezquida, Gisela|||0000-0002-6080-2203 Sánchez-Torres, Ana Maria|||0000-0002-9505-2406 Amoretti, Silvia|||0000-0001-6017-2734 Lobo, Antonio|||0000-0002-9098-655X González-Pinto, Ana|||0000-0002-2568-5179 Andreu-Bernabeu, Álvaro Corripio, Iluminada|||0000-0003-2562-711X Vieta, Eduard|||0000-0002-0548-0053 Baeza, Inmaculada|||0000-0003-2611-5781 Mané, Anna|||0000-0003-2127-349X Cuesta, Manuel J.|||0000-0003-0250-5718 de la Serna, Elena|||0000-0002-7869-9881 Payá, Beatriz Zorrilla, Iñaki|||0000-0001-6444-8208 Arango, Celso|||0000-0003-3382-4754 Bernardo, Miquel|||0000-0001-8748-6717 Rapado-Castro, Marta|||0000-0001-8484-6051 Parellada, Mara|||0000-0001-7977-3601 |
| author |
Molina-García, Mariola |
| author_facet |
Molina-García, Mariola Fraguas, David|||0000-0002-7931-2933 del Rey-Mejías, Ángel|||0000-0003-1690-3215 Mezquida, Gisela|||0000-0002-6080-2203 Sánchez-Torres, Ana Maria|||0000-0002-9505-2406 Amoretti, Silvia|||0000-0001-6017-2734 Lobo, Antonio|||0000-0002-9098-655X González-Pinto, Ana|||0000-0002-2568-5179 Andreu-Bernabeu, Álvaro Corripio, Iluminada|||0000-0003-2562-711X Vieta, Eduard|||0000-0002-0548-0053 Baeza, Inmaculada|||0000-0003-2611-5781 Mané, Anna|||0000-0003-2127-349X Cuesta, Manuel J.|||0000-0003-0250-5718 de la Serna, Elena|||0000-0002-7869-9881 Payá, Beatriz Zorrilla, Iñaki|||0000-0001-6444-8208 Arango, Celso|||0000-0003-3382-4754 Bernardo, Miquel|||0000-0001-8748-6717 Rapado-Castro, Marta|||0000-0001-8484-6051 Parellada, Mara|||0000-0001-7977-3601 |
| author_role |
author |
| author2 |
Fraguas, David|||0000-0002-7931-2933 del Rey-Mejías, Ángel|||0000-0003-1690-3215 Mezquida, Gisela|||0000-0002-6080-2203 Sánchez-Torres, Ana Maria|||0000-0002-9505-2406 Amoretti, Silvia|||0000-0001-6017-2734 Lobo, Antonio|||0000-0002-9098-655X González-Pinto, Ana|||0000-0002-2568-5179 Andreu-Bernabeu, Álvaro Corripio, Iluminada|||0000-0003-2562-711X Vieta, Eduard|||0000-0002-0548-0053 Baeza, Inmaculada|||0000-0003-2611-5781 Mané, Anna|||0000-0003-2127-349X Cuesta, Manuel J.|||0000-0003-0250-5718 de la Serna, Elena|||0000-0002-7869-9881 Payá, Beatriz Zorrilla, Iñaki|||0000-0001-6444-8208 Arango, Celso|||0000-0003-3382-4754 Bernardo, Miquel|||0000-0001-8748-6717 Rapado-Castro, Marta|||0000-0001-8484-6051 Parellada, Mara|||0000-0001-7977-3601 |
| author2_role |
author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Psychosis First-episode Premorbid intelligence Age at onset Functional outcome Remission Recovery Heterogeneity Subgroup |
| topic |
Psychosis First-episode Premorbid intelligence Age at onset Functional outcome Remission Recovery Heterogeneity Subgroup |
| description |
Background: premorbid IQ (pIQ) and age of onset are predictors of clinical severity and long-term functioning after a first episode of psychosis. However, the additive influence of these variables on clinical, functional, and recovery rates outcomes is largely unknown. Methods: we characterized 255 individuals who have experienced a first episode of psychosis in four a priori defined subgroups based on pIQ (low pIQ < 85; average pIQ ≥ 85) and age of onset (early onset < 18 years; adult onset ≥ 18 years). We conducted clinical and functional assessments at baseline and at two-year follow-up. We calculated symptom remission and recovery rates using the Positive and Negative Symptoms of Schizophrenia Schedule (PANSS) and the Global Assessment Functioning (GAF or Children-GAF). We examined clinical and functional changes with pair-wise comparisons and two-way mixed ANOVA. We built hierarchical lineal and logistic regression models to estimate the predictive value of the independent variables over functioning or recovery rates. Results: early-onset patients had more severe positive symptoms and poorer functioning than adult-onset patients. At two-year follow-up, only early-onset with low pIQ and adult-onset with average pIQ subgroups differed consistently, with the former having more negative symptoms (d = 0.59), poorer functioning (d = 0.82), lower remission (61% vs. 81.1%), and clinical recovery (34.1% vs. 62.2%). Conclusions: early-onset individuals with low pIQ may present persistent negative symptoms, lower functioning, and less recovery likelihood at two-year follow-up. Intensive cognitive and functional programs for these individuals merit testing to improve long-term recovery rates in this subgroup. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2 2021-01-01 2021 2021-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/256433 https://dx.doi.org/urn:doi:10.3390/jcm10112474 |
| url |
https://ddd.uab.cat/record/256433 https://dx.doi.org/urn:doi:10.3390/jcm10112474 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/00481 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/00216 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CD20/00177 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 RYC-2017-23144 Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 24628 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI15/00283 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/00805 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-1365 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 SLT006/17/00357 |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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Dipòsit Digital de Documents de la UAB |
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The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of PsychosisMolina-García, MariolaFraguas, David|||0000-0002-7931-2933del Rey-Mejías, Ángel|||0000-0003-1690-3215Mezquida, Gisela|||0000-0002-6080-2203Sánchez-Torres, Ana Maria|||0000-0002-9505-2406Amoretti, Silvia|||0000-0001-6017-2734Lobo, Antonio|||0000-0002-9098-655XGonzález-Pinto, Ana|||0000-0002-2568-5179Andreu-Bernabeu, ÁlvaroCorripio, Iluminada|||0000-0003-2562-711XVieta, Eduard|||0000-0002-0548-0053Baeza, Inmaculada|||0000-0003-2611-5781Mané, Anna|||0000-0003-2127-349XCuesta, Manuel J.|||0000-0003-0250-5718de la Serna, Elena|||0000-0002-7869-9881Payá, BeatrizZorrilla, Iñaki|||0000-0001-6444-8208Arango, Celso|||0000-0003-3382-4754Bernardo, Miquel|||0000-0001-8748-6717Rapado-Castro, Marta|||0000-0001-8484-6051Parellada, Mara|||0000-0001-7977-3601PsychosisFirst-episodePremorbid intelligenceAge at onsetFunctional outcomeRemissionRecoveryHeterogeneitySubgroupBackground: premorbid IQ (pIQ) and age of onset are predictors of clinical severity and long-term functioning after a first episode of psychosis. However, the additive influence of these variables on clinical, functional, and recovery rates outcomes is largely unknown. Methods: we characterized 255 individuals who have experienced a first episode of psychosis in four a priori defined subgroups based on pIQ (low pIQ < 85; average pIQ ≥ 85) and age of onset (early onset < 18 years; adult onset ≥ 18 years). We conducted clinical and functional assessments at baseline and at two-year follow-up. We calculated symptom remission and recovery rates using the Positive and Negative Symptoms of Schizophrenia Schedule (PANSS) and the Global Assessment Functioning (GAF or Children-GAF). We examined clinical and functional changes with pair-wise comparisons and two-way mixed ANOVA. We built hierarchical lineal and logistic regression models to estimate the predictive value of the independent variables over functioning or recovery rates. Results: early-onset patients had more severe positive symptoms and poorer functioning than adult-onset patients. At two-year follow-up, only early-onset with low pIQ and adult-onset with average pIQ subgroups differed consistently, with the former having more negative symptoms (d = 0.59), poorer functioning (d = 0.82), lower remission (61% vs. 81.1%), and clinical recovery (34.1% vs. 62.2%). Conclusions: early-onset individuals with low pIQ may present persistent negative symptoms, lower functioning, and less recovery likelihood at two-year follow-up. Intensive cognitive and functional programs for these individuals merit testing to improve long-term recovery rates in this subgroup.Universitat Autònoma de Barcelona 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/256433https://dx.doi.org/urn:doi:10.3390/jcm10112474reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/00481Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/00216Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CD20/00177Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 RYC-2017-23144Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 24628Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI15/00283Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/00805Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-1365Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 SLT006/17/00357open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2564332026-06-06T12:50:31Z |
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