Lempel-Ziv complexity in schizophrenia: A MEG study
Objective: The neurodevelopmental-neurodegenerative debate is a basic issue in the field of the neuropathological basis of schizophrenia (SCH). Neurophysiological techniques have been scarcely involved in such debate, but nonlinear analysis methods may contribute to it. Methods: Fifteen patients (ag...
| Autores: | , , , , , , , , , |
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| Tipo de documento: | artigo |
| Data de publicação: | 2011 |
| País: | España |
| Recursos: | Universidad Complutense de Madrid (UCM) |
| Repositório: | Docta Complutense |
| Idioma: | inglês |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/44635 |
| Acesso em linha: | https://hdl.handle.net/20.500.14352/44635 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Lempel-Ziv complexity Magnetoencephalography Neurodegenerative Neurodevelopmental Schizophrenia. EMTREE medical terms: adult Age Article Clinical article Controlled study Correlation analysis Female Human Lempel ziv complexity score Logistic regression analysis Male Patient coding Priority journal Schizophrenia Scoring system Sensitivity and specificity. MeSH: Adult Aging Cerebral Cortex Cognition Disorders Disease Progression Humans Schizophrenic Psychology Signal Processing Computer-Assisted Young Adult |
| Resumo: | Objective: The neurodevelopmental-neurodegenerative debate is a basic issue in the field of the neuropathological basis of schizophrenia (SCH). Neurophysiological techniques have been scarcely involved in such debate, but nonlinear analysis methods may contribute to it. Methods: Fifteen patients (age range 23-42. years) matching DSM IV-TR criteria for SCH, and 15 sex- and age-matched control subjects (age range 23-42. years) underwent a resting-state magnetoencephalographic evaluation and Lempel-Ziv complexity (LZC) scores were calculated. Results: Regression analyses indicated that LZC values were strongly dependent on age. Complexity scores increased as a function of age in controls, while SCH patients exhibited a progressive reduction of LZC values. A logistic model including LZC scores, age and the interaction of both variables allowed the classification of patients and controls with high sensitivity and specificity. Conclusions: Results demonstrated that SCH patients failed to follow the " normal" process of complexity increase as a function of age. In addition, SCH patients exhibited a significant reduction of complexity scores as a function of age, thus paralleling the pattern observed in neurodegenerative diseases. Significance: Our results support the notion of a progressive defect in SCH, which does not contradict the existence of a basic neurodevelopmental alteration. |
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