Short-term evolution and dispersal patterns of fluconazole-resistance in <i>Candida auris</i> clade III

The rapid increase in infections caused by the emerging fungal pathogen Candida auris is of global concern, and understanding its expansion is a priority. The phylogenetic diversity of the yeast is clustered in five major clades, among which clade III is particularly relevant, as most of its strains...

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Autores: Cancino-Muñoz, I, Mulet-Bayona, JV, Salvador-García, C, Tormo-Palop, N, Guna, R, Gimeno-Cardona, C, González-Candelas, F
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p18296
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/18296
Access Level:acceso abierto
Palabra clave:fungal pathogen
Candida auris
fluconazole resistance
phylogenetic structure
dispersion
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spelling Short-term evolution and dispersal patterns of fluconazole-resistance in <i>Candida auris</i> clade IIICancino-Muñoz, IMulet-Bayona, JVSalvador-García, CTormo-Palop, NGuna, RGimeno-Cardona, CGonzález-Candelas, Ffungal pathogenCandida aurisfluconazole resistancephylogenetic structuredispersionThe rapid increase in infections caused by the emerging fungal pathogen Candida auris is of global concern, and understanding its expansion is a priority. The phylogenetic diversity of the yeast is clustered in five major clades, among which clade III is particularly relevant, as most of its strains exhibit resistance to fluconazole, reducing the therapeutic alternatives and provoking outbreaks that are difficult to control. In this study, we have investigated the phylogenetic structure of clade III by analyzing a global collection of 566 genomes. We have identified three subgroups within clade III, among which two are genetically most closely related. Moreover, we have estimated the evolutionary rate of clade III to be 2.25e-7 s/s/y (2.87 changes per year). We found that one of these subgroups shows intrinsic resistance to fluconazole and is responsible for the majority of cases within this clade globally. We inferred that this subgroup may have originated around December 2010 (95% High Probability Density (HPD): April 2010-June 2011), and since then it has spread across continents, generating multiple large outbreaks, each with a unique pattern of transmission and dissemination. These results highlight the remarkable ability of the pathogen to adapt to its environment and its rapid global spread, underscoring the urgent need to address this epidemiological challenge effectively.AMER SOC MICROBIOLOGY2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/18296mBioISSN: 21612129ISSNe: 21507511reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p182962026-06-11T12:45:17Z
dc.title.none.fl_str_mv Short-term evolution and dispersal patterns of fluconazole-resistance in <i>Candida auris</i> clade III
title Short-term evolution and dispersal patterns of fluconazole-resistance in <i>Candida auris</i> clade III
spellingShingle Short-term evolution and dispersal patterns of fluconazole-resistance in <i>Candida auris</i> clade III
Cancino-Muñoz, I
fungal pathogen
Candida auris
fluconazole resistance
phylogenetic structure
dispersion
title_short Short-term evolution and dispersal patterns of fluconazole-resistance in <i>Candida auris</i> clade III
title_full Short-term evolution and dispersal patterns of fluconazole-resistance in <i>Candida auris</i> clade III
title_fullStr Short-term evolution and dispersal patterns of fluconazole-resistance in <i>Candida auris</i> clade III
title_full_unstemmed Short-term evolution and dispersal patterns of fluconazole-resistance in <i>Candida auris</i> clade III
title_sort Short-term evolution and dispersal patterns of fluconazole-resistance in <i>Candida auris</i> clade III
dc.creator.none.fl_str_mv Cancino-Muñoz, I
Mulet-Bayona, JV
Salvador-García, C
Tormo-Palop, N
Guna, R
Gimeno-Cardona, C
González-Candelas, F
author Cancino-Muñoz, I
author_facet Cancino-Muñoz, I
Mulet-Bayona, JV
Salvador-García, C
Tormo-Palop, N
Guna, R
Gimeno-Cardona, C
González-Candelas, F
author_role author
author2 Mulet-Bayona, JV
Salvador-García, C
Tormo-Palop, N
Guna, R
Gimeno-Cardona, C
González-Candelas, F
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv fungal pathogen
Candida auris
fluconazole resistance
phylogenetic structure
dispersion
topic fungal pathogen
Candida auris
fluconazole resistance
phylogenetic structure
dispersion
description The rapid increase in infections caused by the emerging fungal pathogen Candida auris is of global concern, and understanding its expansion is a priority. The phylogenetic diversity of the yeast is clustered in five major clades, among which clade III is particularly relevant, as most of its strains exhibit resistance to fluconazole, reducing the therapeutic alternatives and provoking outbreaks that are difficult to control. In this study, we have investigated the phylogenetic structure of clade III by analyzing a global collection of 566 genomes. We have identified three subgroups within clade III, among which two are genetically most closely related. Moreover, we have estimated the evolutionary rate of clade III to be 2.25e-7 s/s/y (2.87 changes per year). We found that one of these subgroups shows intrinsic resistance to fluconazole and is responsible for the majority of cases within this clade globally. We inferred that this subgroup may have originated around December 2010 (95% High Probability Density (HPD): April 2010-June 2011), and since then it has spread across continents, generating multiple large outbreaks, each with a unique pattern of transmission and dissemination. These results highlight the remarkable ability of the pathogen to adapt to its environment and its rapid global spread, underscoring the urgent need to address this epidemiological challenge effectively.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/18296
url https://fisabio.portalinvestigacion.com/publicaciones/18296
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv AMER SOC MICROBIOLOGY
publisher.none.fl_str_mv AMER SOC MICROBIOLOGY
dc.source.none.fl_str_mv mBio
ISSN: 21612129
ISSNe: 21507511
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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