Usefulness of Arterial Stiffness as an Integrated Marker of Cardiovascular Risk

We analyzed the usefulness of the carotid-femoral pulse wave velocity (cfPWV) as an integrated marker for hypertension (HTN)-mediated organ damage (HMOD) and cardiovascular (CV) risk in a cohort with repeated measurements. A total of 1031 patients, 80% of whom had HTN, underwent cfPWV determinations...

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Detalles Bibliográficos
Autores: Prado, G, Forner, MJ, Calaforra, O, Vela, S, Bea, C, Pichler, G, de Gracia, A, Serna, L, Rodilla, E, Redon, J, Martínez-García, F
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p19942
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/19942
Access Level:acceso abierto
Palabra clave:complications
hypertension (HTN)
longitudinal studies
pulse wave analysis
vascular stiffness (AS)
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spelling Usefulness of Arterial Stiffness as an Integrated Marker of Cardiovascular RiskPrado, GForner, MJCalaforra, OVela, SBea, CPichler, Gde Gracia, ASerna, LRodilla, ERedon, JMartínez-García, Fcomplicationshypertension (HTN)longitudinal studiespulse wave analysisvascular stiffness (AS)We analyzed the usefulness of the carotid-femoral pulse wave velocity (cfPWV) as an integrated marker for hypertension (HTN)-mediated organ damage (HMOD) and cardiovascular (CV) risk in a cohort with repeated measurements. A total of 1031 patients, 80% of whom had HTN, underwent cfPWV determinations by SphygmoCor. An HMOD score was developed, including microalbuminuria, left ventricular hypertrophy (LVH), intima-media thickness (IMT), and carotid plaques. CV complications included atrial fibrillation (AF), heart failure (HF), stroke, ischemic heart disease (IHD), peripheral artery disease (PAD), or CV death. Survival curves based on Cox regression adjusted for age and systolic blood pressure (SBP), along with Harrell's C statistic, were assessed. There was a trend toward higher cfPWV across categories of the HMOD score. Significant correlations were found among different AS parameters and blood pressure (BP) levels. Age and SBP were highly correlated with cfPWV. Among the 174 patients with at least two cfPWV measurements, there were 12 CV complications over a follow-up period of 2.4 years. The first and second cfPWV measurements, as well as the delta values, were significantly higher in those with CV complications, with most patients experiencing an increase in PWV during follow-up of >= 1 m/s. Survival curves significantly differed among tertiles of PWV and the delta, particularly for the second PWV determination, which also showed the highest predictive value (Harrell's C = 0.86). The optimal threshold to predict complications was 9.10 m/s. Our findings suggest that cfPWV represents a promising integrated marker of HMOD, potentially serving as a surrogate endpoint for CV risk.WILEY2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/19942Journal of Clinical HypertensionISSN: 15246175ISSNe: 17517176reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p199422026-06-07T16:35:31Z
dc.title.none.fl_str_mv Usefulness of Arterial Stiffness as an Integrated Marker of Cardiovascular Risk
title Usefulness of Arterial Stiffness as an Integrated Marker of Cardiovascular Risk
spellingShingle Usefulness of Arterial Stiffness as an Integrated Marker of Cardiovascular Risk
Prado, G
complications
hypertension (HTN)
longitudinal studies
pulse wave analysis
vascular stiffness (AS)
title_short Usefulness of Arterial Stiffness as an Integrated Marker of Cardiovascular Risk
title_full Usefulness of Arterial Stiffness as an Integrated Marker of Cardiovascular Risk
title_fullStr Usefulness of Arterial Stiffness as an Integrated Marker of Cardiovascular Risk
title_full_unstemmed Usefulness of Arterial Stiffness as an Integrated Marker of Cardiovascular Risk
title_sort Usefulness of Arterial Stiffness as an Integrated Marker of Cardiovascular Risk
dc.creator.none.fl_str_mv Prado, G
Forner, MJ
Calaforra, O
Vela, S
Bea, C
Pichler, G
de Gracia, A
Serna, L
Rodilla, E
Redon, J
Martínez-García, F
author Prado, G
author_facet Prado, G
Forner, MJ
Calaforra, O
Vela, S
Bea, C
Pichler, G
de Gracia, A
Serna, L
Rodilla, E
Redon, J
Martínez-García, F
author_role author
author2 Forner, MJ
Calaforra, O
Vela, S
Bea, C
Pichler, G
de Gracia, A
Serna, L
Rodilla, E
Redon, J
Martínez-García, F
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv complications
hypertension (HTN)
longitudinal studies
pulse wave analysis
vascular stiffness (AS)
topic complications
hypertension (HTN)
longitudinal studies
pulse wave analysis
vascular stiffness (AS)
description We analyzed the usefulness of the carotid-femoral pulse wave velocity (cfPWV) as an integrated marker for hypertension (HTN)-mediated organ damage (HMOD) and cardiovascular (CV) risk in a cohort with repeated measurements. A total of 1031 patients, 80% of whom had HTN, underwent cfPWV determinations by SphygmoCor. An HMOD score was developed, including microalbuminuria, left ventricular hypertrophy (LVH), intima-media thickness (IMT), and carotid plaques. CV complications included atrial fibrillation (AF), heart failure (HF), stroke, ischemic heart disease (IHD), peripheral artery disease (PAD), or CV death. Survival curves based on Cox regression adjusted for age and systolic blood pressure (SBP), along with Harrell's C statistic, were assessed. There was a trend toward higher cfPWV across categories of the HMOD score. Significant correlations were found among different AS parameters and blood pressure (BP) levels. Age and SBP were highly correlated with cfPWV. Among the 174 patients with at least two cfPWV measurements, there were 12 CV complications over a follow-up period of 2.4 years. The first and second cfPWV measurements, as well as the delta values, were significantly higher in those with CV complications, with most patients experiencing an increase in PWV during follow-up of >= 1 m/s. Survival curves significantly differed among tertiles of PWV and the delta, particularly for the second PWV determination, which also showed the highest predictive value (Harrell's C = 0.86). The optimal threshold to predict complications was 9.10 m/s. Our findings suggest that cfPWV represents a promising integrated marker of HMOD, potentially serving as a surrogate endpoint for CV risk.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/19942
url https://incliva.portalinvestigacion.com/publicaciones/19942
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv Journal of Clinical Hypertension
ISSN: 15246175
ISSNe: 17517176
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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