Interval Cancer in Population-Based Colorectal Screening Programmes: Incidence and Characteristics of Tumours

Simple Summary Faecal occult blood test interval cancer is one of the potential harms of colorectal cancer screening programmes. These tumours are diagnosed in people who have previously received a negative result in a screening test. The objective of this study was to evaluate interval cancer rates...

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Authors: Vanaclocha-Espí M, Pinto-Carbó M, Ibáñez J, Valverde-Roig MJ, Portillo I, Pérez-Riquelme F, de la Vega M, Castán-Cameo S, Salas D, Molina-Barceló A
Format: article
Status:Published version
Publication Date:2024
Country:España
Institution:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repository:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p16858
Online Access:https://fisabio.portalinvestigacion.com/publicaciones/16858
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85185959921&doi=10.3390%2fcancers16040769&partnerID=40&md5=28aabb81b6b1ece7ad4a5abbce481204
Access Level:Open access
Keyword:colorectal cancer
screening
faecal immunochemical test
personalisation strategies
decision aids
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spelling Interval Cancer in Population-Based Colorectal Screening Programmes: Incidence and Characteristics of TumoursVanaclocha-Espí MPinto-Carbó MIbáñez JValverde-Roig MJPortillo IPérez-Riquelme Fde la Vega MCastán-Cameo SSalas DMolina-Barceló Acolorectal cancerscreeningfaecal immunochemical testpersonalisation strategiesdecision aidsSimple Summary Faecal occult blood test interval cancer is one of the potential harms of colorectal cancer screening programmes. These tumours are diagnosed in people who have previously received a negative result in a screening test. The objective of this study was to evaluate interval cancer rates in colorectal cancer screening programmes in Spain, assess their risk factors and compare the characteristics of screen-detected and interval cancer tumours. Identifying interval cancer rates as well as the associated factors would make it possible to improve screening strategies and identify personal variables related to the occurrence of interval cancer. Furthermore, studying the characteristics that distinguish interval cancers from screen-detected cancers would help us understand the nature of these tumours. These results would help evaluate and improve colorectal cancer screening programmes, increase their quality and minimise interval cancer in such programmes.Abstract The objective of this study is to evaluate interval cancer (IC) in colorectal cancer (CRC) screening, which is CRC diagnosed in an individual after having received a negative faecal occult blood test and before the next invitation to participate in screening. A follow-up study was conducted on a cohort of participants in the first three screening rounds of four colorectal cancer screening programmes in Spain, n = 664,993. A total of 321 ICs and 2120 screen-detected cancers (SCs) were found. The IC and SC rates were calculated for each guaiac (gFOBT) or immunochemical (FIT) test. A Cox regression model was used to estimate the hazard ratios (HR) of IC risk factors. A nested case-control study was carried out to compare IC and SC tumour characteristics. The IC rate was 1.16 parts per thousand with the gFOBT and 0.35 parts per thousand with the FIT. Men and people aged 60-69 showed an increased probability of IC (HR = 1.81 and HR = 1.95, respectively). There was a decreased probability of IC in individuals who regularly participated in screening, HR = 0.62 (0.47-0.82). IC risk gradually rose as the amount of Hb detected in the FIT increased. IC tumours were in more advanced stages and of a larger size than SC tumours, and they were mostly located in the cecum. These results may play a key role in future strategies for screening programmes, reducing IC incidence.MDPI2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/16858https://www.scopus.com/inward/record.uri?eid=2-s2.0-85185959921&doi=10.3390%2fcancers16040769&partnerID=40&md5=28aabb81b6b1ece7ad4a5abbce481204CancersISSN: 20726694reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p168582026-06-11T12:45:17Z
dc.title.none.fl_str_mv Interval Cancer in Population-Based Colorectal Screening Programmes: Incidence and Characteristics of Tumours
title Interval Cancer in Population-Based Colorectal Screening Programmes: Incidence and Characteristics of Tumours
spellingShingle Interval Cancer in Population-Based Colorectal Screening Programmes: Incidence and Characteristics of Tumours
Vanaclocha-Espí M
colorectal cancer
screening
faecal immunochemical test
personalisation strategies
decision aids
title_short Interval Cancer in Population-Based Colorectal Screening Programmes: Incidence and Characteristics of Tumours
title_full Interval Cancer in Population-Based Colorectal Screening Programmes: Incidence and Characteristics of Tumours
title_fullStr Interval Cancer in Population-Based Colorectal Screening Programmes: Incidence and Characteristics of Tumours
title_full_unstemmed Interval Cancer in Population-Based Colorectal Screening Programmes: Incidence and Characteristics of Tumours
title_sort Interval Cancer in Population-Based Colorectal Screening Programmes: Incidence and Characteristics of Tumours
dc.creator.none.fl_str_mv Vanaclocha-Espí M
Pinto-Carbó M
Ibáñez J
Valverde-Roig MJ
Portillo I
Pérez-Riquelme F
de la Vega M
Castán-Cameo S
Salas D
Molina-Barceló A
author Vanaclocha-Espí M
author_facet Vanaclocha-Espí M
Pinto-Carbó M
Ibáñez J
Valverde-Roig MJ
Portillo I
Pérez-Riquelme F
de la Vega M
Castán-Cameo S
Salas D
Molina-Barceló A
author_role author
author2 Pinto-Carbó M
Ibáñez J
Valverde-Roig MJ
Portillo I
Pérez-Riquelme F
de la Vega M
Castán-Cameo S
Salas D
Molina-Barceló A
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv colorectal cancer
screening
faecal immunochemical test
personalisation strategies
decision aids
topic colorectal cancer
screening
faecal immunochemical test
personalisation strategies
decision aids
description Simple Summary Faecal occult blood test interval cancer is one of the potential harms of colorectal cancer screening programmes. These tumours are diagnosed in people who have previously received a negative result in a screening test. The objective of this study was to evaluate interval cancer rates in colorectal cancer screening programmes in Spain, assess their risk factors and compare the characteristics of screen-detected and interval cancer tumours. Identifying interval cancer rates as well as the associated factors would make it possible to improve screening strategies and identify personal variables related to the occurrence of interval cancer. Furthermore, studying the characteristics that distinguish interval cancers from screen-detected cancers would help us understand the nature of these tumours. These results would help evaluate and improve colorectal cancer screening programmes, increase their quality and minimise interval cancer in such programmes.Abstract The objective of this study is to evaluate interval cancer (IC) in colorectal cancer (CRC) screening, which is CRC diagnosed in an individual after having received a negative faecal occult blood test and before the next invitation to participate in screening. A follow-up study was conducted on a cohort of participants in the first three screening rounds of four colorectal cancer screening programmes in Spain, n = 664,993. A total of 321 ICs and 2120 screen-detected cancers (SCs) were found. The IC and SC rates were calculated for each guaiac (gFOBT) or immunochemical (FIT) test. A Cox regression model was used to estimate the hazard ratios (HR) of IC risk factors. A nested case-control study was carried out to compare IC and SC tumour characteristics. The IC rate was 1.16 parts per thousand with the gFOBT and 0.35 parts per thousand with the FIT. Men and people aged 60-69 showed an increased probability of IC (HR = 1.81 and HR = 1.95, respectively). There was a decreased probability of IC in individuals who regularly participated in screening, HR = 0.62 (0.47-0.82). IC risk gradually rose as the amount of Hb detected in the FIT increased. IC tumours were in more advanced stages and of a larger size than SC tumours, and they were mostly located in the cecum. These results may play a key role in future strategies for screening programmes, reducing IC incidence.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/16858
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85185959921&doi=10.3390%2fcancers16040769&partnerID=40&md5=28aabb81b6b1ece7ad4a5abbce481204
url https://fisabio.portalinvestigacion.com/publicaciones/16858
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85185959921&doi=10.3390%2fcancers16040769&partnerID=40&md5=28aabb81b6b1ece7ad4a5abbce481204
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Cancers
ISSN: 20726694
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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