Interactive Hemocompatible Nanocoating to Prevent Surface‐Induced Coagulation in Medical Devices

Interfacing blood with any artificial surface instantly triggers the activation of coagulation at the interface, posing a risk of adverse thromboembolic complications. Immediately upon contact, blood proteins adsorb to the surface turning it into an active prothrombogenic and proinflammatory interfa...

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Autores: Quandt, Jonas, Garay Sarmiento, Manuela, Witzdam, Lena, Englert, Jenny, Rutsch, Yannik, Stöecker, Cornelia, Obstals, Fabian, Grottke, Oliver, Rodriguez Emmenegger, César
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/189103
Acceso en línea:https://hdl.handle.net/2445/189103
Access Level:acceso abierto
Palabra clave:Coagulació sanguínia
Revestiments
Nanomedicina
Blood coagulation
Coatings
Nanomedicine
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spelling Interactive Hemocompatible Nanocoating to Prevent Surface‐Induced Coagulation in Medical DevicesQuandt, JonasGaray Sarmiento, ManuelaWitzdam, LenaEnglert, JennyRutsch, YannikStöecker, CorneliaObstals, FabianGrottke, OliverRodriguez Emmenegger, CésarCoagulació sanguíniaRevestimentsNanomedicinaBlood coagulationCoatingsNanomedicineInterfacing blood with any artificial surface instantly triggers the activation of coagulation at the interface, posing a risk of adverse thromboembolic complications. Immediately upon contact, blood proteins adsorb to the surface turning it into an active prothrombogenic and proinflammatory interface promoting the activation of platelets and the coagulation cascade. Here, an interactive hemocompatible nanocoating is designed that synergistically combines antifouling polymer brushes with the activity of an anti-FXIIa antibody to tackle the two main causes of surface-induced coagulation. The brushes provide a passive layer rendering the surface stealth and non-thrombogenic against blood activation. Furthermore, as soon as traces of FXIIa arise, the coating immediately and specifically scavenges it, thus actively switching-off contact activation right at the beginning. Moreover, a means is developed to translate this coating to a broad range of polymeric surfaces commonly used in medical devices. The coated surfaces prevent protein adsorption and provide a barrier to bacterial colonization while being capable of capturing biologically relevant concentrations of FXIIa. Notably, the coating completely prevents the formation of clots on the surface when exposed to blood. Thus, the interactive anti-FXIIa nanocoating provides a new avenue to improve the hemocompatibility of medical devices in a safe and efficient manner.Wiley-VCH GmbH2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/189103Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1002/admi.202201055Advanced Materials Interfaces, 2022, num. 2201055https://doi.org/10.1002/admi.202201055cc by-nc (c) Quandt, Jonas et al., 2022http://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1891032026-05-27T06:46:51Z
dc.title.none.fl_str_mv Interactive Hemocompatible Nanocoating to Prevent Surface‐Induced Coagulation in Medical Devices
title Interactive Hemocompatible Nanocoating to Prevent Surface‐Induced Coagulation in Medical Devices
spellingShingle Interactive Hemocompatible Nanocoating to Prevent Surface‐Induced Coagulation in Medical Devices
Quandt, Jonas
Coagulació sanguínia
Revestiments
Nanomedicina
Blood coagulation
Coatings
Nanomedicine
title_short Interactive Hemocompatible Nanocoating to Prevent Surface‐Induced Coagulation in Medical Devices
title_full Interactive Hemocompatible Nanocoating to Prevent Surface‐Induced Coagulation in Medical Devices
title_fullStr Interactive Hemocompatible Nanocoating to Prevent Surface‐Induced Coagulation in Medical Devices
title_full_unstemmed Interactive Hemocompatible Nanocoating to Prevent Surface‐Induced Coagulation in Medical Devices
title_sort Interactive Hemocompatible Nanocoating to Prevent Surface‐Induced Coagulation in Medical Devices
dc.creator.none.fl_str_mv Quandt, Jonas
Garay Sarmiento, Manuela
Witzdam, Lena
Englert, Jenny
Rutsch, Yannik
Stöecker, Cornelia
Obstals, Fabian
Grottke, Oliver
Rodriguez Emmenegger, César
author Quandt, Jonas
author_facet Quandt, Jonas
Garay Sarmiento, Manuela
Witzdam, Lena
Englert, Jenny
Rutsch, Yannik
Stöecker, Cornelia
Obstals, Fabian
Grottke, Oliver
Rodriguez Emmenegger, César
author_role author
author2 Garay Sarmiento, Manuela
Witzdam, Lena
Englert, Jenny
Rutsch, Yannik
Stöecker, Cornelia
Obstals, Fabian
Grottke, Oliver
Rodriguez Emmenegger, César
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Coagulació sanguínia
Revestiments
Nanomedicina
Blood coagulation
Coatings
Nanomedicine
topic Coagulació sanguínia
Revestiments
Nanomedicina
Blood coagulation
Coatings
Nanomedicine
description Interfacing blood with any artificial surface instantly triggers the activation of coagulation at the interface, posing a risk of adverse thromboembolic complications. Immediately upon contact, blood proteins adsorb to the surface turning it into an active prothrombogenic and proinflammatory interface promoting the activation of platelets and the coagulation cascade. Here, an interactive hemocompatible nanocoating is designed that synergistically combines antifouling polymer brushes with the activity of an anti-FXIIa antibody to tackle the two main causes of surface-induced coagulation. The brushes provide a passive layer rendering the surface stealth and non-thrombogenic against blood activation. Furthermore, as soon as traces of FXIIa arise, the coating immediately and specifically scavenges it, thus actively switching-off contact activation right at the beginning. Moreover, a means is developed to translate this coating to a broad range of polymeric surfaces commonly used in medical devices. The coated surfaces prevent protein adsorption and provide a barrier to bacterial colonization while being capable of capturing biologically relevant concentrations of FXIIa. Notably, the coating completely prevents the formation of clots on the surface when exposed to blood. Thus, the interactive anti-FXIIa nanocoating provides a new avenue to improve the hemocompatibility of medical devices in a safe and efficient manner.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/189103
url https://hdl.handle.net/2445/189103
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1002/admi.202201055
Advanced Materials Interfaces, 2022, num. 2201055
https://doi.org/10.1002/admi.202201055
dc.rights.none.fl_str_mv cc by-nc (c) Quandt, Jonas et al., 2022
http://creativecommons.org/licenses/by-nc/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc (c) Quandt, Jonas et al., 2022
http://creativecommons.org/licenses/by-nc/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley-VCH GmbH
publisher.none.fl_str_mv Wiley-VCH GmbH
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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