Advantages of intraoperative implant for interstitial brachytherapy for accelerated partial breast irradiation either frail patients with early-stage disease or in locally recurrent breast cancer

Purpose: to describe the intraoperative multicatheter implantation technique for accelerated partial breast irradiation (APBI) delivered with high-dose-rate brachytherapy (HDR-BT). Secondarily, to evaluate outcomes and toxicity in a series of 83 patients treated with this technique at our institutio...

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Autores: Cozzi, Salvatore, Laplana, Maria, Najjari, Dina, Slocker, Andrea, Encinas, Xavier, Pera Fàbregas, Joan, Guedea Edo, Ferran, Gutiérrez Miguélez, Cristina
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/175628
Acceso en línea:https://hdl.handle.net/2445/175628
Access Level:acceso abierto
Palabra clave:Braquiteràpia
Càncer de mama
Catèters
Radioisotope brachytherapy
Breast cancer
Catheters
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spelling Advantages of intraoperative implant for interstitial brachytherapy for accelerated partial breast irradiation either frail patients with early-stage disease or in locally recurrent breast cancerCozzi, SalvatoreLaplana, MariaNajjari, DinaSlocker, AndreaEncinas, XavierPera Fàbregas, JoanGuedea Edo, FerranGutiérrez Miguélez, CristinaBraquiteràpiaCàncer de mamaCatètersRadioisotope brachytherapyBreast cancerCathetersPurpose: to describe the intraoperative multicatheter implantation technique for accelerated partial breast irradiation (APBI) delivered with high-dose-rate brachytherapy (HDR-BT). Secondarily, to evaluate outcomes and toxicity in a series of 83 patients treated with this technique at our institution. Material and methods: retrospective analysis of a series of patients treated with HDR-BT APBI after intraoperative multicatheter interstitial implant between November 2006 and June 2017 at our institution. We assessed cosmesis, toxicity, overall survival (OS), and disease-free survival (DFS). Results: eighty-three patients were included: 59 patients (71.1%) with primary early-stage breast cancer and 24 (28.9%) with locally recurrent breast cancer. Tumorectomy was performed in all cases, with intraoperative tumor margin assessment and sentinel node biopsy. Median age was 82 years (range, 44-92). The total prescribed dose was 32 Gy (8 treatment fractions) in 60 patients (72.3%), and 34 Gy (10 fractions) in 23 patients (27.7%). Median follow-up was 40 months (range, 1-136 months). Three-year OS and DFS in the recurrent and primary cancer groups were 87% vs. 89%, and 96 % vs. 97.8%, respectively. Five patients died from non-cancer related causes. No local relapses were observed. Rates of acute and late toxicity were low in both groups. The cosmesis was good or excellent in most of patients treated for primary disease; in patients who underwent salvage brachytherapy for local recurrence, cosmesis was good in 49 patients and fair in 6. Conclusions: this technique, although time-consuming, achieves good local disease control with a satisfactory toxicity profile in both early-stage and local recurrent breast cancer patients. It may be especially suitable for frail patients.Polish Brachytherapy Society2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/175628Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.5114/jcb.2018.75594Journal of Contemporary Brachytherapy, 2018, vol. 10, num. 2, p. 97-104https://doi.org/10.5114/jcb.2018.75594(c) Polish Brachytherapy Society, 2018info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1756282026-05-27T06:46:51Z
dc.title.none.fl_str_mv Advantages of intraoperative implant for interstitial brachytherapy for accelerated partial breast irradiation either frail patients with early-stage disease or in locally recurrent breast cancer
title Advantages of intraoperative implant for interstitial brachytherapy for accelerated partial breast irradiation either frail patients with early-stage disease or in locally recurrent breast cancer
spellingShingle Advantages of intraoperative implant for interstitial brachytherapy for accelerated partial breast irradiation either frail patients with early-stage disease or in locally recurrent breast cancer
Cozzi, Salvatore
Braquiteràpia
Càncer de mama
Catèters
Radioisotope brachytherapy
Breast cancer
Catheters
title_short Advantages of intraoperative implant for interstitial brachytherapy for accelerated partial breast irradiation either frail patients with early-stage disease or in locally recurrent breast cancer
title_full Advantages of intraoperative implant for interstitial brachytherapy for accelerated partial breast irradiation either frail patients with early-stage disease or in locally recurrent breast cancer
title_fullStr Advantages of intraoperative implant for interstitial brachytherapy for accelerated partial breast irradiation either frail patients with early-stage disease or in locally recurrent breast cancer
title_full_unstemmed Advantages of intraoperative implant for interstitial brachytherapy for accelerated partial breast irradiation either frail patients with early-stage disease or in locally recurrent breast cancer
title_sort Advantages of intraoperative implant for interstitial brachytherapy for accelerated partial breast irradiation either frail patients with early-stage disease or in locally recurrent breast cancer
dc.creator.none.fl_str_mv Cozzi, Salvatore
Laplana, Maria
Najjari, Dina
Slocker, Andrea
Encinas, Xavier
Pera Fàbregas, Joan
Guedea Edo, Ferran
Gutiérrez Miguélez, Cristina
author Cozzi, Salvatore
author_facet Cozzi, Salvatore
Laplana, Maria
Najjari, Dina
Slocker, Andrea
Encinas, Xavier
Pera Fàbregas, Joan
Guedea Edo, Ferran
Gutiérrez Miguélez, Cristina
author_role author
author2 Laplana, Maria
Najjari, Dina
Slocker, Andrea
Encinas, Xavier
Pera Fàbregas, Joan
Guedea Edo, Ferran
Gutiérrez Miguélez, Cristina
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Braquiteràpia
Càncer de mama
Catèters
Radioisotope brachytherapy
Breast cancer
Catheters
topic Braquiteràpia
Càncer de mama
Catèters
Radioisotope brachytherapy
Breast cancer
Catheters
description Purpose: to describe the intraoperative multicatheter implantation technique for accelerated partial breast irradiation (APBI) delivered with high-dose-rate brachytherapy (HDR-BT). Secondarily, to evaluate outcomes and toxicity in a series of 83 patients treated with this technique at our institution. Material and methods: retrospective analysis of a series of patients treated with HDR-BT APBI after intraoperative multicatheter interstitial implant between November 2006 and June 2017 at our institution. We assessed cosmesis, toxicity, overall survival (OS), and disease-free survival (DFS). Results: eighty-three patients were included: 59 patients (71.1%) with primary early-stage breast cancer and 24 (28.9%) with locally recurrent breast cancer. Tumorectomy was performed in all cases, with intraoperative tumor margin assessment and sentinel node biopsy. Median age was 82 years (range, 44-92). The total prescribed dose was 32 Gy (8 treatment fractions) in 60 patients (72.3%), and 34 Gy (10 fractions) in 23 patients (27.7%). Median follow-up was 40 months (range, 1-136 months). Three-year OS and DFS in the recurrent and primary cancer groups were 87% vs. 89%, and 96 % vs. 97.8%, respectively. Five patients died from non-cancer related causes. No local relapses were observed. Rates of acute and late toxicity were low in both groups. The cosmesis was good or excellent in most of patients treated for primary disease; in patients who underwent salvage brachytherapy for local recurrence, cosmesis was good in 49 patients and fair in 6. Conclusions: this technique, although time-consuming, achieves good local disease control with a satisfactory toxicity profile in both early-stage and local recurrent breast cancer patients. It may be especially suitable for frail patients.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/175628
url https://hdl.handle.net/2445/175628
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.5114/jcb.2018.75594
Journal of Contemporary Brachytherapy, 2018, vol. 10, num. 2, p. 97-104
https://doi.org/10.5114/jcb.2018.75594
dc.rights.none.fl_str_mv (c) Polish Brachytherapy Society, 2018
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Polish Brachytherapy Society, 2018
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Polish Brachytherapy Society
publisher.none.fl_str_mv Polish Brachytherapy Society
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,30478

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