Impact of switching from lopinavir/ritonavir to atazanavir/ritonavir on body fat redistribution in virologically suppressed HIV-infected adults

Changes in body fat distribution in virologically suppressed HIV-infected patients switching from lopinavir/ritonavir (LPV/r) to atazanavir/ritonavir (ATV/r) were assessed. A prospective comparative study was conducted of 37 patients receiving LPV/r regimens switching to ATV/r with 46 patients conti...

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Autores: Ferrer, Elena, Río, Luis del, Martínez Chamorro, Esteban José, Curto, J. J. (Jorge Juan), Domingo, Pere (Domingo Pedrol), Ribera, Esteban, Negredo, Eugènia, Rosales, Joaquín, Saumoy, Maria, Ordóñez, J. (Jordi), 1952-, Gatell, José M., Podzamczer Palter, Daniel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2011
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/118961
Acceso en línea:https://hdl.handle.net/2445/118961
Access Level:acceso abierto
Palabra clave:VIH (Virus)
Antiretrovirals
Infeccions per VIH
Obesitat
Teixit adipós
HIV (Viruses)
Antiretroviral agents
HIV infections
Obesity
Adipose tissues
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spelling Impact of switching from lopinavir/ritonavir to atazanavir/ritonavir on body fat redistribution in virologically suppressed HIV-infected adultsFerrer, ElenaRío, Luis delMartínez Chamorro, Esteban JoséCurto, J. J. (Jorge Juan)Domingo, Pere (Domingo Pedrol)Ribera, EstebanNegredo, EugèniaRosales, JoaquínSaumoy, MariaOrdóñez, J. (Jordi), 1952-Gatell, José M.Podzamczer Palter, DanielVIH (Virus)AntiretroviralsInfeccions per VIHObesitatTeixit adipósHIV (Viruses)Antiretroviral agentsHIV infectionsObesityAdipose tissuesChanges in body fat distribution in virologically suppressed HIV-infected patients switching from lopinavir/ritonavir (LPV/r) to atazanavir/ritonavir (ATV/r) were assessed. A prospective comparative study was conducted of 37 patients receiving LPV/r regimens switching to ATV/r with 46 patients continuing with LPV/r. Body composition was assessed with whole-body dual-energy x-ray absorptiometry (DXA). Abdominal CT scans were also performed in a subset of patients. Groups were comparable in baseline demographic, clinical, and anthropometric characteristics. After 12 months, peripheral fat did not change significantly, but an increase in trunk fat was observed only in the ATV/r group (0.87 kg, p = 0.021). The percentage of patients with an increase ≥20% in total fat was 37.8% and 15.2% in the ATV/r and LPV/r groups, respectively (p = 0.018). In the ATV/r group, the increase in trunk fat (9.4%) was significantly higher than in peripheral fat (3.7%) (p = 0.007), leading to a significant increase in fat mass ratio (3.76%, p = 0.028), whereas no significant differences were found among LPV/r patients. CT scans showed that abdominal fat increase corresponded to both visceral (28%, p = 0.008) and subcutaneous fat (42%, p = 0.008). These data suggest that switching from LPV/r to ATV/r is associated with increased trunk fat, both subcutaneous and visceral.Mary Ann Liebert2018201820112018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion5 p.application/pdfhttps://hdl.handle.net/2445/118961Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1089/AID.2010.0254Aids Research and Human Retroviruses, 2011, vol. 27, num. 10, p. 1061-1065https://doi.org/10.1089/AID.2010.0254(c) Mary Ann Liebert, 2011info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1189612026-05-29T05:05:01Z
dc.title.none.fl_str_mv Impact of switching from lopinavir/ritonavir to atazanavir/ritonavir on body fat redistribution in virologically suppressed HIV-infected adults
title Impact of switching from lopinavir/ritonavir to atazanavir/ritonavir on body fat redistribution in virologically suppressed HIV-infected adults
spellingShingle Impact of switching from lopinavir/ritonavir to atazanavir/ritonavir on body fat redistribution in virologically suppressed HIV-infected adults
Ferrer, Elena
VIH (Virus)
Antiretrovirals
Infeccions per VIH
Obesitat
Teixit adipós
HIV (Viruses)
Antiretroviral agents
HIV infections
Obesity
Adipose tissues
title_short Impact of switching from lopinavir/ritonavir to atazanavir/ritonavir on body fat redistribution in virologically suppressed HIV-infected adults
title_full Impact of switching from lopinavir/ritonavir to atazanavir/ritonavir on body fat redistribution in virologically suppressed HIV-infected adults
title_fullStr Impact of switching from lopinavir/ritonavir to atazanavir/ritonavir on body fat redistribution in virologically suppressed HIV-infected adults
title_full_unstemmed Impact of switching from lopinavir/ritonavir to atazanavir/ritonavir on body fat redistribution in virologically suppressed HIV-infected adults
title_sort Impact of switching from lopinavir/ritonavir to atazanavir/ritonavir on body fat redistribution in virologically suppressed HIV-infected adults
dc.creator.none.fl_str_mv Ferrer, Elena
Río, Luis del
Martínez Chamorro, Esteban José
Curto, J. J. (Jorge Juan)
Domingo, Pere (Domingo Pedrol)
Ribera, Esteban
Negredo, Eugènia
Rosales, Joaquín
Saumoy, Maria
Ordóñez, J. (Jordi), 1952-
Gatell, José M.
Podzamczer Palter, Daniel
author Ferrer, Elena
author_facet Ferrer, Elena
Río, Luis del
Martínez Chamorro, Esteban José
Curto, J. J. (Jorge Juan)
Domingo, Pere (Domingo Pedrol)
Ribera, Esteban
Negredo, Eugènia
Rosales, Joaquín
Saumoy, Maria
Ordóñez, J. (Jordi), 1952-
Gatell, José M.
Podzamczer Palter, Daniel
author_role author
author2 Río, Luis del
Martínez Chamorro, Esteban José
Curto, J. J. (Jorge Juan)
Domingo, Pere (Domingo Pedrol)
Ribera, Esteban
Negredo, Eugènia
Rosales, Joaquín
Saumoy, Maria
Ordóñez, J. (Jordi), 1952-
Gatell, José M.
Podzamczer Palter, Daniel
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv VIH (Virus)
Antiretrovirals
Infeccions per VIH
Obesitat
Teixit adipós
HIV (Viruses)
Antiretroviral agents
HIV infections
Obesity
Adipose tissues
topic VIH (Virus)
Antiretrovirals
Infeccions per VIH
Obesitat
Teixit adipós
HIV (Viruses)
Antiretroviral agents
HIV infections
Obesity
Adipose tissues
description Changes in body fat distribution in virologically suppressed HIV-infected patients switching from lopinavir/ritonavir (LPV/r) to atazanavir/ritonavir (ATV/r) were assessed. A prospective comparative study was conducted of 37 patients receiving LPV/r regimens switching to ATV/r with 46 patients continuing with LPV/r. Body composition was assessed with whole-body dual-energy x-ray absorptiometry (DXA). Abdominal CT scans were also performed in a subset of patients. Groups were comparable in baseline demographic, clinical, and anthropometric characteristics. After 12 months, peripheral fat did not change significantly, but an increase in trunk fat was observed only in the ATV/r group (0.87 kg, p = 0.021). The percentage of patients with an increase ≥20% in total fat was 37.8% and 15.2% in the ATV/r and LPV/r groups, respectively (p = 0.018). In the ATV/r group, the increase in trunk fat (9.4%) was significantly higher than in peripheral fat (3.7%) (p = 0.007), leading to a significant increase in fat mass ratio (3.76%, p = 0.028), whereas no significant differences were found among LPV/r patients. CT scans showed that abdominal fat increase corresponded to both visceral (28%, p = 0.008) and subcutaneous fat (42%, p = 0.008). These data suggest that switching from LPV/r to ATV/r is associated with increased trunk fat, both subcutaneous and visceral.
publishDate 2011
dc.date.none.fl_str_mv 2011
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/118961
url https://hdl.handle.net/2445/118961
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1089/AID.2010.0254
Aids Research and Human Retroviruses, 2011, vol. 27, num. 10, p. 1061-1065
https://doi.org/10.1089/AID.2010.0254
dc.rights.none.fl_str_mv (c) Mary Ann Liebert, 2011
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Mary Ann Liebert, 2011
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 5 p.
application/pdf
dc.publisher.none.fl_str_mv Mary Ann Liebert
publisher.none.fl_str_mv Mary Ann Liebert
dc.source.none.fl_str_mv Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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