LncRNAs in the type I interferon antiviral response

The proper functioning of the immune system requires a robust control over a delicate equilibrium between an ineffective response and immune overactivation. Poor responses to viral insults may lead to chronic or overwhelming infection, whereas unrestrained activation can cause autoimmune diseases an...

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Autores: Suarez, B. (Beatriz)|||/items/66d58bdd-e563-485c-972b-acbb15add53b, Prats-Mari, L. (Laura)|||/items/0f1ea27b-6af1-455e-906f-718353c79996, Unfried, J.P. (Juan P.)|||/items/76d5306d-e6d9-4ec5-92fa-2013e828c78e, Fortes, P. (Puri)|||/items/4b719a39-983d-402a-bb2a-2bdd276be18e
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/66474
Acceso en línea:https://hdl.handle.net/10171/66474
Access Level:acceso abierto
Palabra clave:LncRNAs
Type I IFN
Antiviral response
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spelling LncRNAs in the type I interferon antiviral responseSuarez, B. (Beatriz)|||/items/66d58bdd-e563-485c-972b-acbb15add53bPrats-Mari, L. (Laura)|||/items/0f1ea27b-6af1-455e-906f-718353c79996Unfried, J.P. (Juan P.)|||/items/76d5306d-e6d9-4ec5-92fa-2013e828c78eFortes, P. (Puri)|||/items/4b719a39-983d-402a-bb2a-2bdd276be18eLncRNAsType I IFNAntiviral responseThe proper functioning of the immune system requires a robust control over a delicate equilibrium between an ineffective response and immune overactivation. Poor responses to viral insults may lead to chronic or overwhelming infection, whereas unrestrained activation can cause autoimmune diseases and cancer. Control over the magnitude and duration of the antiviral immune response is exerted by a finely tuned positive or negative regulation at the DNA, RNA, and protein level of members of the type I interferon (IFN) signaling pathways and on the expression and activity of antiviral and proinflammatory factors. As summarized in this review, committed research during the last decade has shown that several of these processes are exquisitely regulated by long non-coding RNAs (lncRNAs), transcripts with poor coding capacity, but highly versatile functions. After infection, viruses, and the antiviral response they trigger, deregulate the expression of a subset of specific lncRNAs that function to promote or repress viral replication by inactivating or potentiating the antiviral response, respectively. These IFN-related lncRNAs are also highly tissue- and cell-type-specific, rendering them as promising biomarkers or therapeutic candidates to modulate specific stages of the antiviral immune response with fewer adverse effects.MDPI AGDadun. Depósito Académico Digital Universidad de Navarra20232023-05-3020202020-01-0120202020-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/66474reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/664742026-06-21T12:47:57Z
dc.title.none.fl_str_mv LncRNAs in the type I interferon antiviral response
title LncRNAs in the type I interferon antiviral response
spellingShingle LncRNAs in the type I interferon antiviral response
Suarez, B. (Beatriz)|||/items/66d58bdd-e563-485c-972b-acbb15add53b
LncRNAs
Type I IFN
Antiviral response
title_short LncRNAs in the type I interferon antiviral response
title_full LncRNAs in the type I interferon antiviral response
title_fullStr LncRNAs in the type I interferon antiviral response
title_full_unstemmed LncRNAs in the type I interferon antiviral response
title_sort LncRNAs in the type I interferon antiviral response
dc.creator.none.fl_str_mv Suarez, B. (Beatriz)|||/items/66d58bdd-e563-485c-972b-acbb15add53b
Prats-Mari, L. (Laura)|||/items/0f1ea27b-6af1-455e-906f-718353c79996
Unfried, J.P. (Juan P.)|||/items/76d5306d-e6d9-4ec5-92fa-2013e828c78e
Fortes, P. (Puri)|||/items/4b719a39-983d-402a-bb2a-2bdd276be18e
author Suarez, B. (Beatriz)|||/items/66d58bdd-e563-485c-972b-acbb15add53b
author_facet Suarez, B. (Beatriz)|||/items/66d58bdd-e563-485c-972b-acbb15add53b
Prats-Mari, L. (Laura)|||/items/0f1ea27b-6af1-455e-906f-718353c79996
Unfried, J.P. (Juan P.)|||/items/76d5306d-e6d9-4ec5-92fa-2013e828c78e
Fortes, P. (Puri)|||/items/4b719a39-983d-402a-bb2a-2bdd276be18e
author_role author
author2 Prats-Mari, L. (Laura)|||/items/0f1ea27b-6af1-455e-906f-718353c79996
Unfried, J.P. (Juan P.)|||/items/76d5306d-e6d9-4ec5-92fa-2013e828c78e
Fortes, P. (Puri)|||/items/4b719a39-983d-402a-bb2a-2bdd276be18e
author2_role author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv LncRNAs
Type I IFN
Antiviral response
topic LncRNAs
Type I IFN
Antiviral response
description The proper functioning of the immune system requires a robust control over a delicate equilibrium between an ineffective response and immune overactivation. Poor responses to viral insults may lead to chronic or overwhelming infection, whereas unrestrained activation can cause autoimmune diseases and cancer. Control over the magnitude and duration of the antiviral immune response is exerted by a finely tuned positive or negative regulation at the DNA, RNA, and protein level of members of the type I interferon (IFN) signaling pathways and on the expression and activity of antiviral and proinflammatory factors. As summarized in this review, committed research during the last decade has shown that several of these processes are exquisitely regulated by long non-coding RNAs (lncRNAs), transcripts with poor coding capacity, but highly versatile functions. After infection, viruses, and the antiviral response they trigger, deregulate the expression of a subset of specific lncRNAs that function to promote or repress viral replication by inactivating or potentiating the antiviral response, respectively. These IFN-related lncRNAs are also highly tissue- and cell-type-specific, rendering them as promising biomarkers or therapeutic candidates to modulate specific stages of the antiviral immune response with fewer adverse effects.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01
2020
2020-01-01
2023
2023-05-30
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/66474
url https://hdl.handle.net/10171/66474
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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