Impact of supplementation with vitamins B(6) , B(12) , and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: A systematic review.

Olaso-Gonzalez, G; Inzitari, M; Bellelli, G; Morandi, A; Barcons, N; Vina, J

Impact of supplementation with vitamins B(6) , B(12) , and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: A systematic review.

Hyperhomocysteinemia is an independent predictor of the risk for cognitive decline and may be a result of low levels of vitamins B(12) , B(6) , and folate. Previous findings suggest that adequate intake of these vitamins may reduce homocysteine levels. This review aimed to assess the effects of trea...

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Autores:	Olaso-Gonzalez, G, Inzitari, M, Bellelli, G, Morandi, A, Barcons, N, Vina, J
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2022
País:	España
Institución:	INCLIVA
Repositorio:	r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:	oai:incliva.fundanetsuite.com:p16212
Acceso en línea:	https://incliva.portalinvestigacion.com/publicaciones/16212
Access Level:	acceso abierto
Palabra clave:	folic acid homocysteine mild cognitive impairment vitamin B12 vitamin B6

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spelling	Impact of supplementation with vitamins B(6) , B(12) , and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: A systematic review.Olaso-Gonzalez, GInzitari, MBellelli, GMorandi, ABarcons, NVina, Jfolic acidhomocysteinemild cognitive impairmentvitamin B12vitamin B6Hyperhomocysteinemia is an independent predictor of the risk for cognitive decline and may be a result of low levels of vitamins B(12) , B(6) , and folate. Previous findings suggest that adequate intake of these vitamins may reduce homocysteine levels. This review aimed to assess the effects of treatment with vitamins B(6,) B(12) , and/or folic acid in the homocysteine levels in patients with mild cognitive impairment (MCI). A systematic literature review was conducted in EMBASE, MEDLINE®, PsycINFO, and Cochrane Central Register of Controlled Trials. The research question was formulated using the Population, Intervention, Comparison, and Outcome (PICO) framework: in patients with MCI (P); what is the efficacy of vitamins B(6) , B(12) , and/or folic acid intake (I); compared with baseline values, and/or compared with controls (C); in reducing homocysteine levels from baseline (O). A total of eight primary studies with a total of 1,140 participants were included in the review. Four were randomized controlled trials, one was a quasi-controlled trial, and three were observational studies. All studies included folic acid in their intervention, seven vitamin B(12) , and four vitamin B(6) . Mean (SD) length of the intervention period was 18.8 (19.3) months, ranging from 1 to 60 months. All studies showed a statistically significant decrease in homocysteine levels in groups treated with vitamins B(6,) B(12) , and/or folic acid compared to controls, with a mean decline of homocysteine concentration of 31.9% in the intervention arms whereas it increased by 0.7% in the control arm. This review identified evidence of a reduction of plasma homocysteine levels in MCI patients taking vitamins B(6,) B(12) , and/or folic acid supplements, with statistically significant declines being observed after 1 month of supplementation. Findings support that supplementation with these vitamins might be an option to reduce homocysteine levels in people with MCI and elevated plasma homocysteine.WILEY2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/16212IUBMB LIFEISSN: 15216543ISSNe: 15216551reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p162122026-06-07T16:35:31Z
dc.title.none.fl_str_mv	Impact of supplementation with vitamins B(6) , B(12) , and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: A systematic review.
title	Impact of supplementation with vitamins B(6) , B(12) , and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: A systematic review.
spellingShingle	Impact of supplementation with vitamins B(6) , B(12) , and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: A systematic review. Olaso-Gonzalez, G folic acid homocysteine mild cognitive impairment vitamin B12 vitamin B6
title_short	Impact of supplementation with vitamins B(6) , B(12) , and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: A systematic review.
title_full	Impact of supplementation with vitamins B(6) , B(12) , and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: A systematic review.
title_fullStr	Impact of supplementation with vitamins B(6) , B(12) , and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: A systematic review.
title_full_unstemmed	Impact of supplementation with vitamins B(6) , B(12) , and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: A systematic review.
title_sort	Impact of supplementation with vitamins B(6) , B(12) , and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: A systematic review.
dc.creator.none.fl_str_mv	Olaso-Gonzalez, G Inzitari, M Bellelli, G Morandi, A Barcons, N Vina, J
author	Olaso-Gonzalez, G
author_facet	Olaso-Gonzalez, G Inzitari, M Bellelli, G Morandi, A Barcons, N Vina, J
author_role	author
author2	Inzitari, M Bellelli, G Morandi, A Barcons, N Vina, J
author2_role	author author author author author
dc.subject.none.fl_str_mv	folic acid homocysteine mild cognitive impairment vitamin B12 vitamin B6
topic	folic acid homocysteine mild cognitive impairment vitamin B12 vitamin B6
description	Hyperhomocysteinemia is an independent predictor of the risk for cognitive decline and may be a result of low levels of vitamins B(12) , B(6) , and folate. Previous findings suggest that adequate intake of these vitamins may reduce homocysteine levels. This review aimed to assess the effects of treatment with vitamins B(6,) B(12) , and/or folic acid in the homocysteine levels in patients with mild cognitive impairment (MCI). A systematic literature review was conducted in EMBASE, MEDLINE®, PsycINFO, and Cochrane Central Register of Controlled Trials. The research question was formulated using the Population, Intervention, Comparison, and Outcome (PICO) framework: in patients with MCI (P); what is the efficacy of vitamins B(6) , B(12) , and/or folic acid intake (I); compared with baseline values, and/or compared with controls (C); in reducing homocysteine levels from baseline (O). A total of eight primary studies with a total of 1,140 participants were included in the review. Four were randomized controlled trials, one was a quasi-controlled trial, and three were observational studies. All studies included folic acid in their intervention, seven vitamin B(12) , and four vitamin B(6) . Mean (SD) length of the intervention period was 18.8 (19.3) months, ranging from 1 to 60 months. All studies showed a statistically significant decrease in homocysteine levels in groups treated with vitamins B(6,) B(12) , and/or folic acid compared to controls, with a mean decline of homocysteine concentration of 31.9% in the intervention arms whereas it increased by 0.7% in the control arm. This review identified evidence of a reduction of plasma homocysteine levels in MCI patients taking vitamins B(6,) B(12) , and/or folic acid supplements, with statistically significant declines being observed after 1 month of supplementation. Findings support that supplementation with these vitamins might be an option to reduce homocysteine levels in people with MCI and elevated plasma homocysteine.
publishDate	2022
dc.date.none.fl_str_mv	2022
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://incliva.portalinvestigacion.com/publicaciones/16212
url	https://incliva.portalinvestigacion.com/publicaciones/16212
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	WILEY
publisher.none.fl_str_mv	WILEY
dc.source.none.fl_str_mv	IUBMB LIFE ISSN: 15216543 ISSNe: 15216551 reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA instname:INCLIVA
instname_str	INCLIVA
reponame_str	r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection	r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Impact of supplementation with vitamins B(6) , B(12) , and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: A systematic review.

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