Advances in absolute protein quantification and quantitative protein mapping using ICP-MS

Protein and peptide detection with inductively coupled plasma mass spectrometry (ICP-MS) can provide their direct and reliable absolute quantification without the need for specific standards, which greatly complements molecular mass spectrometry features in proteomics. We discuss recent research to...

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Detalles Bibliográficos
Autores: Cid-Barrio, Laura, Calderón Celis, Francisco, Abásolo-Linares, Patricia, Fernández-Sánchez, M. Luisa, Costa-Fernández, José Manuel, Ruiz Encinar, Jorge, Sanz-Medel, Alfredo
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/39485
Acceso en línea:https://hdl.handle.net/10902/39485
Access Level:acceso abierto
Palabra clave:ICP-MS
Absolute quantification
Elemental labelling
Heteroatom tag
Laser ablation
Mass spectrometry
Targeted proteomics
Descripción
Sumario:Protein and peptide detection with inductively coupled plasma mass spectrometry (ICP-MS) can provide their direct and reliable absolute quantification without the need for specific standards, which greatly complements molecular mass spectrometry features in proteomics. We discuss recent research to shed new light on this particular surge in the analytical applicability of ICP-MS and identify possible niches that could attract future analytical activity within this emerging field.

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